High blood pressure or hypertension is a common long-standing condition, which may cause complications if not treated. Fortunately, it can be managed with changes in lifestyle and medications.

Candesartan and Bisoprolol are used alone or with other drugs to manage blood pressure. They can also help to lower your risk of heart failure.

In this article, you will understand more about hypertension, how these medicines can help, and which is a better option for you.

How Does Medication Help Control High Blood Pressure?

Lifestyle modification is the first-line treatment in managing hypertension. Some factors that can help are being physically active, eating a heart-healthy diet, limiting your alcohol intake, and maintaining a healthy weight.

In some cases, medications may not be sufficient to control blood pressure, and your doctor will prescribe medications to manage your condition.

Many different medicines can help you to treat hypertension. Some remove excess fluids from your body, while others relax your blood vessels.

You can read more about medications for managing hypertension here.

Candesartan and Lowering High Blood Pressure

Candesartan belongs to the class of drugs known as angiotensin II receptor blocker (ARB). By controlling blood pressure, it can help prevent congestive heart failure.

Blood pressure depends on the resistance to blood when it flows to your arteries and the effort put by your heart to pump blood to other body parts. So, narrowing of arteries is one of the causes of high blood pressure.

Angiotensin II is a chemical formed in your blood. When attached to its receptors on muscles around your blood vessels, Angiotensin II contracts them. This causes your blood vessels to narrow, increasing the pressure within them.

Angiotensin II receptor blockers (ARBs) prevent this action by blocking angiotensin II from binding to its receptors on the muscles surrounding the blood vessels. All this relaxes your blood vessels, lowering blood pressure.

This decrease in blood pressure also lowers the load on your heart, reducing the risk of congestive heart failure.

ARBs are used to treat high blood pressure and heart failure. They can also prevent kidney failure in people with diabetes or high blood pressure. ARBs are effective in patients with high blood pressure and an enlarged heart to prevent diabetes and reduce the risk of stroke. ARBs may also prevent the recurrence of atrial fibrillation.

Bisoprolol And High Blood Pressure

Bisoprolol belongs to the class of drug known as beta-blockers. These medicines work by blocking chemicals responsible for contracting blood vessels, increasing blood pressure.

Adrenaline is a hormone produced by your body during stressful events that contract muscles. It also results in excessive sweating, high blood pressure, rapid heartbeat, heart palpitations, and anxiety.

Bisoprolol lowers the stress on your heart by blocking adrenaline action, taking the pressure off the heart and blood vessels. It also prevents the risk of heart attacks and death due to heart complications.

All in all, it is an ideal choice of medicine in individuals with cardiovascular symptoms such as angina.

Comparing the Two- Similarities V/S Differences

Side effects of both Candesartan and Bisoprolol are similar, including diarrhea, rash, and fatigue.

Side effects that are different are:

Side Effects

Bisoprolol 

Additions side effects include:

  • Stomach cramps
  • Vomiting
  • Nausea
  • Diarrhea
  • Blurred vision
  • Rash
  • Insomnia
  • Disorientation
  • Hair loss
  • Fatigue
  • Weakness
  • Muscle cramps
  • Depression
  • Dizziness
  • Hallucinations
  • Headache
  • Confusion
  • Nightmares

Candesartan

Other side effects are:

  • Cough
  • Low blood pressure
  • Headache
  • Dizziness
  • Diarrhea
  • Drowsiness
  • High potassium levels
  • Rash
  • Fatigue
  • Abnormal taste in the mouth
  • Upper respiratory tract infection
  • Indigestion
  • Liver failure
  • Kidney failure
  • Allergic reactions
  • Destruction of muscles

Interactions

Bisoprolol

  • Ergotamine and its derivatives
  • Rifampicin
  • Mefloquine
  • Adrenaline
  • Dobutamine
  • Noradrenaline
  • Medicines used for certain eye disorders such as glaucoma (increased pressure in the eye) or used to widen the pupil of the eye
  • Acetyl salicylic acid
  • Diclofenac
  • Indomethacin
  • Ibuprofen
  • Naproxen
  • Medicines for asthma or medications used for a blocked nose
  • Barbiturates such as phenobarbital
  • Phenothiazines such as levomepromazine
  • Imipramine
  • Amitriptyline
  • Moclobemide
  • Amiodarone
  • Amlodipine
  • Clonidine
  • Digitalis glycosides
  • Diltiazem
  • Disopyramide
  • Felodipine
  • Flecainide
  • Lidocaine
  • Methyldopa
  • Moxonidine
  • Phenytoin
  • Propafenone
  • Quinidine
  • Rilmenidine
  • Verapamil

Candesartan

  • Captopril
  • Enalaprilat
  • Fosinopril
  • Lithium
  • Perindopril
  • Quinapril
  • Trandolapril
  • Trimethoprim
  • Bufexamac
  • Choline Salicylate
  • Dexibuprofen
  • Diclofenac
  • Diflunisal
  • Droxicam
  • Etodolac
  • Etoricoxib
  • Fenoprofen
  • Feprazone
  • Flufenamic acid
  • Flurbiprofen
  • Ibuprofen
  • Indomethacin
  • Ketorolac
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Meloxicam
  • Morniflumate
  • Naproxen
  • Nepafenac
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Phenylbutazone
  • Piketoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Salicylic Acid
  • Sodium Salicylate
  • Tenoxicam
  • Tolfenamic Acid
  • Tolmetin

Which Is the Right One for You?

An ideal choice of medicine for hypertension depends on your condition. Candesartan is mainly used to prevent cardiovascular complications such as heart failure and stroke. 

On the other hand, Bisoprolol is used to control blood pressure when symptoms of heart disorders are already present, such as angina. It thus lowers mortality due to heart problems.

Use and Dosage

Your doctor will decide the ideal dose based on various factors, such as:

  • Age
  • Blood pressure readings
  • Health disorders
  • Medications you may be taking

Candesartan

Adults

The standard dose is 16 mg to be taken once a day. It could range between 8-32 mg in a single or divided dose.

Children (ages 6 to 17 years)

The standard dose is 4–8 mg per day for kids weighing less than 50kg. It may range between 2–16 mg a day.

The dose is 8–16 mg per day for kids weighing more than 50 kgs. It may range between 4–32 mg a day.

The dose can be taken as a single dose or twice a day in divided doses.

Children (ages 1 to 5 years)

The standard dose is 0.05–0.4 mg/kg of body weight per day or about 0.20 mg/kg per day.

The dose can be taken as a single dose or twice a day in divided doses. 

Bisoprolol

Adults

The standard dose is 5 mg to be taken once a day. It could range between 10 – 20 mg in a single or divided dose.

Children (ages 0 to 17 years)

The use of this medicine is not studied in this age group, and thus its use should be avoided for them.

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