Ozempic and Rybelsus are prescription medications for diabetes and weight loss. They both have the same active ingredient, Semaglutide. However, their way of consumption is different. This article will look at various aspects such as effectiveness, how they work, benefits, side effects, price differences, results, and ease of use. 

Ozempic vs. Rybelsus effectiveness compared

American Diabetes Association (ADA) recommends using either Ozempic or Rybelsus for treating type-2 diabetes. Ozempic is approved for people with type 2 diabetes who have the following conditions:

  • Heart failure 
  • Cardiovascular disease
  • People who are at high risk of developing cardiovascular disease 
  • Kidney disorders

Rybelsus is not approved for managing type 2 diabetes in the mentioned population.

Both the medicines work best when taken along with diet and exercise.

How do Ozempic and Rybelsus work?

Glucagon-like peptide 1 (GLP-1) agonist is a class of antidiabetic medication that regulates, maintains, and improves blood glucose levels in type 2 diabetes. Ozempic and Rybelsus are examples of drugs that belong to the GLP-1 agonist category.  Ozempic and Rybelsus can be used alone or in combination to reduce blood sugar levels. Ozempic and Rybelsus may also promote weight loss. 

This class of drugs mimics the action of glucagon-like peptide 1 (natural chemical). Both the drugs can cause an increase in the secretion of insulin when blood glucose level rises. These medicines thus help in controlling diabetes. 

Benefits of Ozempic and Rybelsus 

Ozempic and Rybelsus are prescription medications used in adults with type 2 diabetes and exercise and diet to manage blood glucose levels. Ozempic and Rybelsus are not approved to treat type-1 diabetes. 

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In addition, Ozempic is used to decrease the risk of cardiac problems with people having cardiovascular problems, diabetes, and who are at a higher risk of heart disease such as:

  • Smoking 
  • Older age 
  • High blood pressure 
  • High cholesterol 

Side effects of Ozempic and Rybelsus 

Ozempic and Rybelsus both belong to the same class of medication. Hence, they both are very similar in terms of everything. Some of the common side effects include: 

  • Fatigue 
  • Nausea 
  • Constipation 
  • Vomiting 
  • Reduced appetite 
  • Abdominal pain 
  • Hypoglycemia (low blood sugar level)
  • Diarrhea 
  • Indigestion 
  • Heartburn 
  • Burping 

If the above side effects are severe or persistent, you should inform your doctor immediately. 

Some of the side effects can be serious, and you should inform your physician immediately or seek emergency medical treatment.

Serious side effects

  • Vision changes 
  • Rapid heartbeat 
  • Rash 
  • Swelling of face, tongue, eyes, face, or throat 
  • Difficulty in breathing or swallowing 
  • Decreased urination 
  • Yellowing of the skin or eyes 
  • Pancreatitis (inflammation of the pancreas)
  • Diabetic neuropathy (damage caused to eyes by diabetes)

The above list is not comprehensive. Ozempic and Rybelsus may cause other side effects. Call your physician if you experience any unusual problems while on this medication. 

Ozempic and Rybelsus have a boxed warning (a serious warning from the Food and Drugs Administration – FDA). Both the drugs have been shown to cause thyroid cancer and thyroid tumors. If you have a family history or personal history of thyroid cancer, you should inform your physician before the treatment is initiated. 

What do reviews have to say for both Ozempic and Rybelsus?

Ozempic and Rybelsus have an almost similar effect in lowering blood sugar levels and reducing weight. There are no studies that compare the functioning of both medicines. 

Ozempic Reviews

Ozempic has an average review of 5.8 out of 10. The most common side effects were headache, nausea, and fatigue. Most people were happy about losing weight with Ozempic.

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Rybelsus Reviews

Rybelsys has an average review of 6.1 out of 10. The most common reported side effects were nausea and a sick feeling in the stomach. People taking medicine were happy as it helped them manage their blood glucose levels.

Your physician will select the appropriate medication for you. 

Ease of use of Ozempic and Rybelsus 

Ozempic comes as a liquid solution available in a prefilled pen, while Rybelsus comes as a tablet to be taken orally. The Ozempic dose depends on the type of pen you use. Rybelsus needs to be taken once a day. 

Price comparison of Ozempic and Rybelsus

Ozempic and Rybelsus approximately cost the same. Ozempic is slightly more expensive. Ozempic costs about $899, while Rybelsus costs about $770. However, the amount you pay depends on the insurance you have.

You can see prices for Ozempic and Rybelsus in the links below:

  1. See Ozempic price in Canada
  2. See Rybelsus price in Canada

Recommended Reading

  1. How to buy Rybelsus online in Canada (Opens in a new browser tab)
  2. What Foods To Avoid When Taking Ozempic? Can you have Metformin or Vitamins? (Opens in a new browser tab)
  3. What are the most common side effects of Ozempic & how to manage them (Opens in a new browser tab)
  4. Ozempic vs Metformin: Side effects, results, price & ease of use compared (Opens in a new browser tab)
  5. Ozempic For Weight Loss Canada – Compared vs Trulicity, Bydureon, Januvia & Lantus (Opens in a new browser tab)
  6. How to buy Ozempic online in Canada

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