If you or your friend or a family member have been recently diagnosed with osteoarthritis and are prescribed celecoxib, keep reading this article to know more about its symptoms, causes. Also, read to know how celecoxib helps treat osteoarthritis, precautions, instructions while taking the medication, and its side effects.

What is osteoarthritis, and what does it look like?

Osteoarthritis is a chronic condition that affects the joints of the body. Osteoarthritis is the most common form of arthritis. Osteoarthritis causes reduced motion, pain, and swelling of the joints. Joints such as knees, hips, hands, shoulder, and spine (neck or lower back) are affected. Osteoarthritis is also known as degenerative joint disease. 

In normal individuals, the joints are protected by the cartilage (a protective tissue around the ends of the bones). In OA, cartilage is broken down, which causes bones with joints to rub together. Thus, causing stiffness, reduced motion, pain, swelling, and other symptoms. 

Causes of Osteoarthritis

Aging is one of the important causes of Osteoarthritis. As you grow older, the stress on your body joints increases and may cause Osteoarthritis. The other causes of Osteoarthritis include: 

  • Obesity 
  • Past injury (dislocated joints, ligament injuries, and torn cartilage) 
  • Poor posture 
  • Joint malfunction

Risk Factors: You are likely to have osteoarthritis if you: 

  • Women (women are more likely to have Osteoarthritis as compared to men)
  • Have undergone menopause 
  • Family history of Osteoarthritis 
  • History of injury to joints 
  • Obesity 
  • Poor posture 
  • Age above 50 years 
  • Having certain occupations (climbing, heavy lifting, kneeling, or similar actions)
  • Other medication conditions (diabetes or different type of arthritis)
  • Already have Osteoarthritis in one part of the body
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Osteoarthritis Symptoms

The most common symptoms of Osteoarthritis include: 

  • Stiffness in the joints 
  • Joint pain 
  • Reduced range of motion of the joints 
  • Loss of flexibility 
  • Inflammation 
  • Tenderness or discomfort when pressing on the affected joints with your fingers 
  • Extra lumps of bone 

The joints’ pain, stiffness, and range of motion are drastically affected as the disease progresses. Over time, the swelling also may occur near the affected joints. 

Celecoxib and preventing osteoarthritis, use and dosage

Celecoxib does not prevent osteoarthritis; however, it helps reduce and manage the symptoms of the disease. 

Celecoxib work by blocking the action of certain chemicals that are associated with inflammation and pain. They block cyclooxygenases (COX) enzyme, and there are two forms of COX enzyme: 

  • COX-1 
  • COX-2 

The COX enzymes control the production of prostaglandins in the body. Prostaglandins are a group of chemicals associated with inflammation, the formation of blood clots, and blood flow. Celecoxib is a selective COX-2 enzyme inhibitor. 

Celecoxib treatment for Osteoarthritis

Celecoxib is available in capsule form and is to be taken orally. Celecoxib may be prescribed once or twice daily. If your daily dose of celecoxib is 200 mg, it can be taken with or without food. If your dose is greater than 200 mg, you should take the medication with food. 

Follow the directions on your prescription label. You can ask your healthcare worker in case of any queries. Take the medication as directed by your healthcare worker. Do not take more or less than prescribed. To help you remember your daily dose, try to take the medication at the same time every day. 

If you miss your dose while taking the medication, consume it as soon as you remember it. In case if it is almost time for your next dose, you can skip the missed dose and follow your regular dosing schedule. Do not consume double doses to make up for the missed dose. 

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Celecoxib Dosage for Osteoarthritis

Usually, celecoxib is prescribed in the range of 100-200 mg, to be taken once or twice per day. The standard adult dose prescribed is 200 mg to be taken once daily or 100 mg twice daily in an evenly spaced dose. 

If celecoxib does not improve your OS pain and symptoms, your doctor may increase your dose to 400 mg (that can be prescribed once daily or 200 mg to be taken twice a day). 

Celecoxib Side effects 

Like all medications, celecoxib also has some side effects. It is possible that you may not experience any side effects. Below mentioned are the side effects. Please inform your doctor immediately if they are severe or if they do not go away:

  • Sore throat
  • Gas
  • Dysgeusia
  • Dizziness 
  • Constipation
  • Cold symptoms   

Stop using the medications if they experience any of the below-mentioned side effects and call your doctor immediately: 

  • Nausea 
  • Itching 
  • Diarrhea 
  • Loss of appetite 
  • Back pain 
  • Lack of energy 
  • Unexplained weight gain 
  • Fatigue
  • Yellowing of skin or eyes
  • Rash
  • Hives 
  • Fever 
  • Pale skin
  • Painful urination 
  • Frequent urination (at night)
  • Hoarseness
  • Swelling of face, lips, eyes, hands, tongue, or throat
  • Fast heartbeat 
  • Difficulty in swallowing
  • Cloudy or discolored urine 
  • Flu-like symptoms 
  • Blisters 
  • Pain in the upper right part of the stomach 

The above-mentioned side effects of each class of medication are not comprehensive. There may likely be other side effects. Call your physician if they experience anything unusual or persistent. 

Other precautions 

Please inform the doctor and pharmacist about allergic to any medication or any of its ingredients. If they have any other allergies, do not forget to share the same with the health care professional. 

Inform your health worker about other prescription, non-prescription medications, and nutritional supplements that are being taken. Also, inform about vitamins and herbal supplements consumed or planned. 

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Pregnancy and Celecoxib

Inform your doctor if they are suffering from any comorbidities. You should inform your physician you are pregnant, planning to get pregnant, or breastfeeding. If you become pregnant while on treatment, inform your doctor immediately.  You should not take Celecoxib after 20 weeks of pregnancy unless advised by the doctor. 

Surgery and dental procedures precautions while on Celecoxib

If you are taking celecoxib, you should inform your doctor before going to surgery or dental procedure. 

Before your treatment begins, inform your doctor if you have asthma, a frequently runny nose, stuffed nose, or nasal polyps (a condition where swelling occurs on the lining of the nose). You should also inform if you have a heart, liver, or kidney disease history.

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