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Exelon Patch 15

Exelon Patch 15

(rivastigmine-transdermal)

Rivastigmine belongs to a family of medications known as cholinesterase inhibitors. It is used to treat symptoms of mild to moderately severe Alzheimer's Disease.

Available form

Dosage

24-Hour Patch

4.6MG/24HR, 9.5MG/24HR, 13.3MG/24HR

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Exelon Patch 15 information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual recommended starting dose is to apply one patch of the lowest dose (4.6 mg released every 24 hours) once a day. Your doctor may increase the dose after 4 weeks of treatment. The highest dose recommended is 13.3 mg every 24 hours.

Apply the patch to clean, dry, non-irritated skin on a flat body surface such as the chest, upper back, lower back, or upper arm. Make sure there is no hair, powder, oil, moisturizer, or lotion at the application site. Press the patch firmly in place with the palm of the hand for approximately 30 seconds, making sure the contact is complete, especially around the edges.

Each patch may be worn continuously for 24 hours, after which time the old patch should be removed and a new patch should be applied. Apply the new patch on a different skin site after removal of the previous one and do not apply a new patch to the same spot for at least 2 weeks. Consult the package insert, your doctor, or your pharmacist for specific instructions on how to use and properly dispose of the medication.

Only one patch may be worn at a time. After 24 hours, there is still medication remaining in the patch. If two patches are worn at the same time, there is a high likelihood of severe side effects occurring, including Heart Attack and death. Do not use the patch if it is cut, damaged, or altered in any way.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Exelon Patch 15 (Rivastigmine-transdermal) exactly as prescribed by your doctor. If you forget to apply a new rivastigmine patch, remove the old one and apply a new patch as soon as possible. Continue with your regular dosing schedule for your next patch. Do not apply two patches to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss more than 3 days of applying the rivastigmine patch, consult your doctor first before you begin to apply the next patch.

Store Exelon Patch 15 (Rivastigmine-transdermal) at room temperature, in the original packaging. Protect it from light and heat, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Exelon Patch 15 (Rivastigmine-transdermal). If you are concerned about side effects, discuss the risks and benefits of Exelon Patch 15 (Rivastigmine-transdermal) with your doctor.

The following side effects have been reported by at least 1% of people taking Exelon Patch 15 (Rivastigmine-transdermal). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

accidental falls
agitation or confusion
anxiety
Constipation
dehydration
Diarrhea
dizziness
drowsiness
fatigue
general feeling of discomfort or illness
headache
increased sweating
itching, irritation, or redness at site of patch application
loss of appetite
nausea
nightmares
stomach discomfort after a meal
stomach pain
trembling
trouble sleeping
Urinary Incontinence
vomiting
weakness
weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

chest pain
dehydration (losing too much fluid)
fainting
hallucinations (seeing, feeling, or hearing things that are not there)
high blood pressure
restlessness
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
skin rash or itching
stiff limbs, trembling hands, body spasms
symptoms of a stomach ulcer (e.g., stomach pain, burning, discomfort, or bloating)
symptoms of a urinary tract infection (e.g., painful or burning urination, frequent urination, or cloudy urine)
worsening Parkinson's Disease symptoms

Stop taking the medication and seek immediate medical attention if any of the following occur:

blistering of the skin, mouth, eyes, or genitals
blood in stools or when vomiting
convulsions (seizures)
fast, slow, or irregular heartbeat
severe confusion
severe vomiting
signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with Fever or discomfort
signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
symptoms of a heart attack (e.g., pain, pressure, or discomfort in the chest, neck, back, or jaw; sweating; shortness of breath; nausea; lightheadedness; or feelings of anxiety, fear, or denial)
symptoms of a Stroke (e.g., sudden paralysis or numbness, difficulty speaking or understanding speech, loss of coordination, severe headache, or vision changes)
symptoms of inflammation of the pancreas (e.g., severe stomach pain with nausea and vomiting)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Exelon Patch 15 (Rivastigmine-transdermal).

There may be an interaction between rivastigmine and any of the following:

alcohol
aclidinium
Amiodarone
antihistamines (e.g., brompheniramine, Chlorpheniramine)
antipsychotic medications (e.g., Aripiprazole, Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine)
atropine
azelastine
belladonna
Benztropine
beta-blockers (e.g., Atenolol, Metoprolol, Propranolol)
Ceritinib
cholinergic medications (e.g., Bethanechol)
Clonidine
corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
Cyclobenzaprine
Darifenacin
Digoxin
Diltiazem
Dipyridamole
Disopyramide
Donepezil
Dronedarone
Fingolimod
Flavoxate
Galantamine
glycopyrrolate
Guanfacine
ipratropium
Ivabradine
ketotifen
Lacosamide
Lanreotide
methyldopa
Metoclopramide
Moclobemide
neuromuscular blocking agents (e.g., atracurium, pancuronium, succinylcholine)
Octreotide
orphenadrine
Oxybutynin
Pasireotide
Propafenone
quinidine
scopolamine
succinylcholine
tiotropium
Tizanidine
Tofacitinib
Tolterodine
Tranylcypromine
tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
umeclidinium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Exelon Patch 15 (Rivastigmine-transdermal). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Exelon Patch 15 (Rivastigmine-transdermal).

Breathing conditions: Rivastigmine may cause breathing problems to worsen. If you have a history of Asthma or obstructive lung disease (e.g., emphysema, chronic Bronchitis), discuss with your doctor how Exelon Patch 15 (Rivastigmine-transdermal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Exelon Patch 15 (Rivastigmine-transdermal), and whether any special monitoring is needed.

Drowsiness/reduced alertness: Exelon Patch 15 (Rivastigmine-transdermal) may cause dizziness or drowsiness, mainly when starting treatment or increasing the dose. Your doctor will advise you whether it is safe for you to drive vehicles and operate machinery. If you feel dizzy or drowsy, do not drive, use machines, or perform any other tasks that require your attention.

Heart disease: People with certain types of heart disease (e.g., Congestive Heart Failure, Coronary Artery Disease) are more likely to experience symptoms of heart disease as a result of rivastigmine slowing down the heart rate. If you have heart disease, discuss with your doctor how Exelon Patch 15 (Rivastigmine-transdermal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Exelon Patch 15 (Rivastigmine-transdermal), and whether any special monitoring is needed.

Incorrect use of medication: Rivastigmine patches are intended to be worn one at a time. Forgetting to remove a patch and applying a second one, can lead to severe, sometimes fatal side effects. If you experience nausea, vomiting, diarrhea, hallucinations, high blood pressure, decreased heart rate or falls, when you previously have tolerated the medication well, this may indicate an incorrect use of the patches. Report any unusual side effects to your doctor as soon as possible.

Kidney function: If you have reduced kidney function or Kidney Disease, discuss with your doctor how Exelon Patch 15 (Rivastigmine-transdermal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Exelon Patch 15 (Rivastigmine-transdermal), and whether any special monitoring is needed.

Liver function: Decreased liver function or liver disease can lead to Exelon Patch 15 (Rivastigmine-transdermal) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Exelon Patch 15 (Rivastigmine-transdermal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Exelon Patch 15 (Rivastigmine-transdermal), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Exelon Patch 15 (Rivastigmine-transdermal). People with severely reduced liver function should not use Exelon Patch 15 (Rivastigmine-transdermal).

Low body weight: People who weigh less than 50 kg may experience more side effects than people who weigh more than 50 kg. Discuss with your doctor any concerns you may have about using the rivastigmine patch.

Seizures: People who have a history of seizures may experience an increase in seizures when using rivastigmine patch. If you have a history of seizures, discuss with your doctor how Exelon Patch 15 (Rivastigmine-transdermal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Exelon Patch 15 (Rivastigmine-transdermal), and whether any special monitoring is needed.

Stomach problems: The use of rivastigmine patch is associated with significant stomach side effects including diarrhea, nausea, vomiting, loss of appetite, and weight loss. If these side effects persist or they bother you, speak to your doctor. If you have a history of stomach ulcers or are at risk of developing ulcers, discuss with your doctor how Exelon Patch 15 (Rivastigmine-transdermal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Exelon Patch 15 (Rivastigmine-transdermal), and whether any special monitoring is needed.

Stopping and restarting treatment: If you miss more than 3 days' worth of treatment, talk to your doctor about how to safely restart the medication.

Surgery: Rivastigmine increases the effects of some medications that are used during surgery. If you are going to have surgery, make sure you let all the doctors, including dentists, know that you are using rivastigmine patch.

Pregnancy: Exelon Patch 15 (Rivastigmine-transdermal) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Exelon Patch 15 (Rivastigmine-transdermal), contact your doctor immediately.

Breast-feeding: It is not known if rivastigmine passes into breast milk. If you are a breast-feeding mother and are taking Exelon Patch 15 (Rivastigmine-transdermal), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Exelon Patch 15 (Rivastigmine-transdermal) have not been established for children.

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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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