Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Jetrea (Ocriplasmin). If you are concerned about side effects, discuss the risks and benefits of Jetrea (Ocriplasmin) with your doctor.

The following side effects have been reported by at least 1% of people taking Jetrea (Ocriplasmin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• eye redness
• eye pain
• increased sensitivity to light

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• bleeding
• double vision
• halos around light
• nausea
• severe blurring or decrease in vision
• signs of eye infection, tear in the Retin A or increased eye pressure (e.g., worsening eye pain, redness, increased sensitivity to light, increased dark spots (floaters) floating in the field of vision)
• vision changes
• vomiting

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Jetrea (Ocriplasmin).

Each vial contains 0.5 mg of Jetrea (Ocriplasmin) in 0.2 mL of solution as a sterile, clear, colourless solution with no preservatives. Nonmedicinal ingredients: citric acid, mannitol, sodium hydroxide (for pH adjustment) and water for injection.

Do not take Jetrea (Ocriplasmin) if you:

• are allergic to Jetrea (Ocriplasmin) or any ingredients of the medication
• have, or may have, an eye infection

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Tell your doctor if you have had an injection of any medicine into the eye recently. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Jetrea (Ocriplasmin).

Eye problems: Jetrea (Ocriplasmin) can cause eye problems such as infection of the inside part of the eye, pain or redness, detachment or tear of the retina, or increased pressure inside the eyes. Contact your doctor immediately if you experience eye pain, increased eye discomfort, worsening eye redness, blurred or reduced vision, increased sensitivity of the eyes to light, or an increase in the number of small particles in your vision.

Vision problems: Jetrea (Ocriplasmin) can cause temporary vision problems that may affect your ability to drive or operate machines. If you experience vision problems, do not drive or operate machines until your vision returns to normal.

Pregnancy: Jetrea (Ocriplasmin) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Jetrea (Ocriplasmin), contact your doctor immediately.

Breast-feeding: It is not known if Jetrea (Ocriplasmin) passes into breast milk. If you are a breast-feeding mother and are taking Jetrea (Ocriplasmin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Jetrea (Ocriplasmin) have not been established for children.