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Neulasta

Neulasta

Pegfilgrastim

Neulasta (Pegfilgrastim) belongs to the family of medications known as granulocyte colony stimulating factors (G-CSF). Neulasta (Pegfilgrastim) helps the bone marrow produce white blood cells which help the body fight infection.

Available form

Injectable

Dosage

6mg/0.6ml

Manufacturers

Amgen, Apotex, Biosimilar Collaborations Ireland Limited, Nora Pharma, Pfizer, Sandoz

Generic brand of

Pegfilgrastim

Buy Neulasta Full drug details

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Neulasta information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended adult dose of Neulasta (Pegfilgrastim) is 6 mg given by subcutaneous (under the skin) injection after each cycle of chemotherapy. Neulasta (Pegfilgrastim) should not be given less than 14 days before chemotherapy and not until 24 hours after chemotherapy.

Neulasta (Pegfilgrastim) is usually given under medical supervision. If you are giving Neulasta (Pegfilgrastim) to yourself, your doctor or health care professional will instruct you on how to use Neulasta (Pegfilgrastim) properly. It is important to use Neulasta (Pegfilgrastim) exactly as prescribed by your doctor.

If you miss a dose of Neulasta (Pegfilgrastim), call your doctor.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Do not shake Neulasta (Pegfilgrastim) vigorously. Shaking Neulasta (Pegfilgrastim) damages the medication, making it less effective. Neulasta (Pegfilgrastim) should be stored in the refrigerator and protected from light. Freezing should be avoided, but if the medication is accidentally frozen, allow it to thaw in the refrigerator before being given. If the medication is accidentally frozen 2 times or is left at room temperature for more than 72 hours, it should be discarded.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Neulasta (Pegfilgrastim). If you are concerned about side effects, discuss the risks and benefits of Neulasta (Pegfilgrastim) with your doctor.

The following side effects have been reported by at least 1% of people taking Neulasta (Pegfilgrastim). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

bone and muscle pain
redness, swelling, or itching at the site of injection

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

rash at the surface of the skin (purple or red spots or bumps, splotches, or Hives)
signs of an enlarged spleen (e.g., upper left abdominal pain or pain at the tip of the shoulder)
symptoms of kidney injury (e.g., puffiness in the face or ankles, blood in the urine or brown coloured urine, decreased frequency of urination)

Stop taking the medication and seek immediate medical attention if any of the following occur:

a Anaphylaxis (severe allergic reaction) (e.g., hives, shortness of breath, wheezing, swelling of the face or throat, fast heart rate, dizziness)
signs of acute respiratory distress syndrome (e.g., Fever, shortness of breath, cough, or lung congestion)
symptoms of capillary leak syndrome (e.g., swelling or puffiness, difficulty breathing, abdominal swelling, tiredness, feeling of fullness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Neulasta (Pegfilgrastim).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Neulasta (Pegfilgrastim).

Capillary leak syndrome (CLS): Capillary leak syndrome been experienced by people using Neulasta (Pegfilgrastim). This is a condition where blood leaks from the small blood vessels, into your body. CLS can cause severely decreased blood pressure and may be life threatening. If you experience symptoms of CLS, such as swelling or puffiness, difficulty breathing, abdominal swelling, tiredness, feeling of fullness, seek immediate medical attention.

Cytotoxic chemotherapy: The safety of using Neulasta (Pegfilgrastim) at the same time as cytotoxic chemotherapy (a type of chemotherapy that kills cells, especially cancer cells) has not been established. Neulasta (Pegfilgrastim) should not be used within 14 days before or 24 hours after chemotherapy. In addition, it is not known whether it is safe and effective to use Neulasta (Pegfilgrastim) after certain chemotherapy medications (e.g., Mitomycin C, 5-fluorouracil, and nitrosoureas such as carmustine and lomustine).

Ruptured spleen: In rare cases, Neulasta (Pegfilgrastim) has been reported to cause the spleen to rupture, which can be fatal. The spleen is an organ in the body that is involved in the production and removal of blood cells. If you have pain in the left upper stomach or left shoulder tip area, contact your doctor immediately.

Lung problems: Neulasta (Pegfilgrastim) may cause adult respiratory distress syndrome (ARDS), a serious lung condition, when people with neutropenia have sepsis (bacterial infection in the blood). If ARDS occurs, Neulasta (Pegfilgrastim) should be stopped until the ARDS resolves.

Radiation: It is not known whether it is safe and effective to use Neulasta (Pegfilgrastim) with radiation therapy. Neulasta (Pegfilgrastim) should not be used during radiation therapy.

Sickle cell disease: Neulasta (Pegfilgrastim) may cause sickle cell crisis when used by people who have sickle cell disease. You and your doctor should carefully consider the benefits and risks of using Neulasta (Pegfilgrastim) in these circumstances.

Pregnancy: Neulasta (Pegfilgrastim) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Neulasta (Pegfilgrastim), stop taking it immediately and call your doctor.

Breast-feeding: It is not known whether Neulasta (Pegfilgrastim) passes into breast milk. If you are a breast-feeding mother and are taking Neulasta (Pegfilgrastim), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Neulasta (Pegfilgrastim) have not been established for children.

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