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Otezla (Apremilast) belongs to the class of medications called immunosuppressants. It is used to treat adults with moderate-to-severe plaque psoriasis who may respond to phototherapy or systemic therapy.
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Otezla (Apremilast) belongs to the class of medications called immunosuppressants. It is used to treat adults with moderate-to-severe plaque psoriasis who may respond to phototherapy or systemic therapy. It may also be used to treat adults with Psoriatic Arthritis who cannot use other disease-modifying treatments, or have tried other treatments which were either not effective, or not well-tolerated.
Plaque psoriasis is a non-contagious skin condition in which parts of the immune system become active, causing inflammation. Psoriatic arthritis is an autoimmune illness which causes joint inflammation. Otezla (Apremilast) works by reducing the activity of a chemical produced in the body that causes this inflammation.
Otezla (Apremilast) is also used to treat mouth ulcers associated with Behcet's disease. Behcet's disease is a rare autoimmune disorder which causes blood vessel inflammation resulting in mouth sores, rashes, and other symptoms throughout the body.
Otezla (Apremilast) may be available under multiple brand names and/or in several different forms. Any specific brand name of Otezla (Apremilast) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Otezla (Apremilast) may not be used for all of the conditions discussed here.
Your doctor may have suggested Otezla (Apremilast) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Otezla (Apremilast), speak to your doctor. Do not stop taking Otezla (Apremilast) without consulting your doctor.
Do not give Otezla (Apremilast) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Otezla (Apremilast) if their doctor has not prescribed it.
We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.
The starting dose of Otezla (Apremilast) is 10 mg daily on the first day, then 10 mg taken in the morning and again in the evening on the second day. The dose is increased by 10 mg each day until the recommended adult dose of 30 mg taken by mouth twice daily has been reached. This gradual dose increase helps to reduce the risk of gastrointestinal side effects such as nausea, vomiting, and Diarrhea.
Otezla (Apremilast) tablets must be swallowed whole with some fluids. Do not split, crush, or chew the tablets. It may be taken with or without food.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Otezla (Apremilast) exactly as prescribed by your doctor.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Otezla (Apremilast) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Otezla (Apremilast). If you are concerned about side effects, discuss the risks and benefits of Otezla (Apremilast) with your doctor.
The following side effects have been reported by at least 1% of people taking Otezla (Apremilast). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Otezla (Apremilast).
Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.
Each pink, diamond-shaped, film-coated tablet, engraved with "APR" on one side and "10" on the other, contains 10 mg of Otezla (Apremilast). Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide red.
Each brown, diamond-shaped, film-coated tablet, engraved with "APR" on one side and "20" on the other, contains 20 mg of Otezla (Apremilast). Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, iron oxide red, and iron oxide yellow.
Each beige, diamond-shaped, film-coated tablet, engraved with "APR" on one side and "30" on the other, contains 30 mg of Otezla (Apremilast). Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, iron oxide red, iron oxide yellow, and iron oxide black.
Do not take Otezla (Apremilast) if you:
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There may be an interaction between Otezla (Apremilast) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Otezla (Apremilast). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Otezla (Apremilast).
Depression: Otezla (Apremilast) may contribute to episodes of depression or thoughts of self-harm. If you have depression or a history of depression, discuss with your doctor how Otezla (Apremilast) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Otezla (Apremilast), and whether any special monitoring is needed.
If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, or decreased interest in activities, or notice them in a family member who is taking Otezla (Apremilast), contact your doctor as soon as possible.
Diarrhea, nausea and vomiting: Otezla (Apremilast) can cause severe diarrhea, nausea, or vomiting, which in turn can lead to dehydration, Low Blood Pressure and also contribute to heart problems. Certain other medications, such as diuretics (water pills) can also cause dehydration. If you experience symptoms of dehydration, such as thirst, decreased urine or tear production, dizziness, or Headaches, contact your doctor as soon as possible.
Kidney function: Kidney Disease or reduced kidney function may cause Otezla (Apremilast) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Otezla (Apremilast) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Otezla (Apremilast), and whether any special monitoring is needed.
Other medications for psoriasis: The safety of using Otezla (Apremilast) in combination with other more potent immunosuppressants or biologicals for the treatment of psoriasis has not been studied. If you are using other medications to treat psoriasis, discuss the safety of doing so with your doctor. Because the safety of combining these therapies has not been evaluated, it is not recommended at this time.
Pregnancy: Otezla (Apremilast) should not be used by women who are pregnant, as there is not enough information about the safety of its use during pregnancy. If you become pregnant while taking Otezla (Apremilast), contact your doctor immediately.
Breast-feeding: It is not known if Otezla (Apremilast) passes into breast milk. If you are a breast-feeding mother and are taking Otezla (Apremilast), it may affect your baby. If you are breast-feeding, you should not take Otezla (Apremilast).
Children: The safety and effectiveness of using Otezla (Apremilast) have not been established for children.
Seniors: Seniors may be at an increased risk of developing complications as a result of severe diarrhea, nausea, and vomiting.
We sort your medication into clearly labeled, individual packs so you can be sure you're taking the right dose at the right time.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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