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August 8, 2022

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Available Form:
TABLET
Manufacturer name:
Janssen
Generic name:
BOSENTAN
Strength:
62.5MG, 125MG
Tracleer (Bosentan) belongs to a class of medications called endothelin receptor antagonists. Tracleer (Bosentan) is used to treat pulmonary arterial hypertension, which is high blood pressure of the blood vessels between the heart and lungs.
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Tracleer (Bosentan) belongs to a class of medications called endothelin receptor antagonists. Tracleer (Bosentan) is used to treat pulmonary arterial hypertension, which is high blood pressure of the blood vessels between the heart and lungs.
Tracleer (Bosentan) works to block the effect of a natural compound called endothelin, which is something the body makes to tighten blood vessels. Blocking the effect of endothelin allows the blood vessels to relax, thereby decreasing the blood pressure between the heart and lungs.
Tracleer (Bosentan) may be available under multiple brand names and/or in several different forms. Any specific brand name of Tracleer (Bosentan) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Tracleer (Bosentan) may not be used for all of the conditions discussed here.
Your doctor may have suggested Tracleer (Bosentan) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Tracleer (Bosentan), speak to your doctor. Do not stop taking Tracleer (Bosentan) without consulting your doctor.
Do not give Tracleer (Bosentan) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Tracleer (Bosentan) if their doctor has not prescribed it.
The recommended starting dose is 62.5 mg twice daily (once in the morning and once in the evening) for 4 weeks. After 4 weeks, the dose is increased to the recommended maintenance dose of 125 mg twice daily. Tracleer (Bosentan) can be taken with or without food. It should be taken consistently.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Tracleer (Bosentan) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Tracleer (Bosentan) at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side-effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Tracleer (Bosentan). If you are concerned about side effects, discuss the risks and benefits of Tracleer (Bosentan) with your doctor.
The following side effects have been reported by at least 1% of people taking Tracleer (Bosentan). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tracleer (Bosentan).
62.5 mg
Each orange-white, round, film-coated tablet, embossed with "62.5" on one side, contains 62.5 mg of Tracleer (Bosentan) monohydrate. Nonmedicinal ingredients: corn starch, glyceryl behenate, magnesium stearate, povidone, pregelatinized starch, sodium starch glycolate, ethylcellulose, hydroxypropyl methylcellulose, iron oxide red, iron oxide yellow, talc, titanium dioxide, and triacetin.
125 mg
Each orange-white, oval, film-coated tablet, embossed with "125" on one side, contains 125 mg of Tracleer (Bosentan) monohydrate. Nonmedicinal ingredients: corn starch, glyceryl behenate, magnesium stearate, povidone, pregelatinized starch, sodium starch glycolate, ethylcellulose, hydroxypropyl methylcellulose, iron oxide red, iron oxide yellow, talc, titanium dioxide, and triacetin.
Do not take Tracleer (Bosentan) if you:
There may be an interaction between Tracleer (Bosentan) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Tracleer (Bosentan). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medication conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Tracleer (Bosentan).
Anemia: Tracleer (Bosentan) can reduce the number of red blood cells, which carry oxygen throughout your body. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.
Your doctor will periodically do blood work to monitor your red blood cell levels to ensure that this does not happen.
Heart failure: People with severe chronic heart failure may see a worsening of their condition when they first start Tracleer (Bosentan). This may be due to fluid retention, which is one of the side effects of Tracleer (Bosentan). If you have severe chronic heart failure, discuss with your doctor how Tracleer (Bosentan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tracleer (Bosentan), and whether any special monitoring is needed.
Liver problems: Tracleer (Bosentan) can affect your liver. Your doctor will perform regular blood tests to make sure your liver is functioning properly. Tracleer (Bosentan) should not be used by people who have moderately to severely reduced liver function.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Low blood pressure: If you have low blood pressure, discuss with your doctor how Tracleer (Bosentan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tracleer (Bosentan), and whether any special monitoring is needed.
Stopping medication: Suddenly stopping Tracleer (Bosentan) may worsen your symptoms. Do not stop taking Tracleer (Bosentan) unless directed by your doctor. If you are stopping treatment, your doctor will monitor you and reduce the dose over a period of time before stopping the medication completely.
Pregnancy: The medication should not be used during pregnancy, as it may cause serious harm to the fetus. Your doctor should perform a pregnancy test before you start Tracleer (Bosentan), and monthly thereafter while you are taking Tracleer (Bosentan). Since Tracleer (Bosentan) decreases the effectiveness of hormonal birth control, you should use more than one form of contraception (e.g., non-hormonal forms such as condoms) while taking Tracleer (Bosentan). If you become pregnant while taking Tracleer (Bosentan), contact your doctor immediately.
Breast-feeding: It is not known if Tracleer (Bosentan) passes into breast milk. If you are a breast-feeding mother and are taking Tracleer (Bosentan), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Tracleer (Bosentan) for children are not well established. Your doctor will determine if the benefits of the medication outweigh the risks for your child.
Seniors: People over 65 years old may be more at risk of side effects from Tracleer (Bosentan) due to age-related decreases in liver function.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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