Tracleer (Bosentan) belongs to a class of medications called endothelin receptor antagonists. Tracleer (Bosentan) is used to treat pulmonary arterial hypertension, which is high blood pressure of the blood vessels between the heart and lungs.

Tracleer (Bosentan) works to block the effect of a natural compound called endothelin, which is something the body makes to tighten blood vessels. Blocking the effect of endothelin allows the blood vessels to relax, thereby decreasing the blood pressure between the heart and lungs.

Tracleer (Bosentan) may be available under multiple brand names and/or in several different forms. Any specific brand name of Tracleer (Bosentan) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Tracleer (Bosentan) may not be used for all of the conditions discussed here.

Your doctor may have suggested Tracleer (Bosentan) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Tracleer (Bosentan), speak to your doctor. Do not stop taking Tracleer (Bosentan) without consulting your doctor.

Do not give Tracleer (Bosentan) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Tracleer (Bosentan) if their doctor has not prescribed it.

The recommended starting dose is 62.5 mg twice daily (once in the morning and once in the evening) for 4 weeks. After 4 weeks, the dose is increased to the recommended maintenance dose of 125 mg twice daily. Tracleer (Bosentan) can be taken with or without food. It should be taken consistently.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Tracleer (Bosentan) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Tracleer (Bosentan) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side-effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Tracleer (Bosentan). If you are concerned about side effects, discuss the risks and benefits of Tracleer (Bosentan) with your doctor.

The following side effects have been reported by at least 1% of people taking Tracleer (Bosentan). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects

• Diarrhea
• fatigue
• flu-like symptoms (e.g., Fever, cough, sore throat, runny nose, headache)
• flushing
• headache
• heartburn
• inflammation of the throat and nasal passages
• itching
• Low Blood Pressure
• nasal congestion
• nausea
• skin rash
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• abdominal pain
• chest pain
• irregular heartbeat
• swelling of the ankles and legs
• swelling in other parts of the body (severe)
• symptoms of Anemia (e.g., fatigue, shortness of breath)
• symptoms of liver problems (e.g., yellowing of the skin or eyes, nausea, vomiting, fever, abdominal pain, or unusual tiredness)
• wheezing

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (e.g., swelling of face or throat, Hives, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tracleer (Bosentan).

62.5 mg
Each orange-white, round, film-coated tablet, embossed with "62.5" on one side, contains 62.5 mg of Tracleer (Bosentan) monohydrate. Nonmedicinal ingredients: corn starch, glyceryl behenate, magnesium stearate, povidone, pregelatinized starch, sodium starch glycolate, ethylcellulose, hydroxypropyl methylcellulose, iron oxide red, iron oxide yellow, talc, titanium dioxide, and triacetin.

125 mg
Each orange-white, oval, film-coated tablet, embossed with "125" on one side, contains 125 mg of Tracleer (Bosentan) monohydrate. Nonmedicinal ingredients: corn starch, glyceryl behenate, magnesium stearate, povidone, pregelatinized starch, sodium starch glycolate, ethylcellulose, hydroxypropyl methylcellulose, iron oxide red, iron oxide yellow, talc, titanium dioxide, and triacetin.

Do not take Tracleer (Bosentan) if you:

• are allergic to Tracleer (Bosentan) or any ingredients of the medication
• are pregnant, planning to become pregnant, or may become pregnant (unless using adequate contraception)
• are taking a medication called Cyclosporine A
• are taking a medication called Glyburide
• have moderately to severely reduced liver function

There may be an interaction between Tracleer (Bosentan) and any of the following:

• Abiraterone acetate
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Silodosin, Tamsulosin)
• Amiodarone
• anticancer medications (e.g., Cabazitaxel, Docetaxel, Doxorubicin, Etoposide, Ifosfamide, Irinotecan, Vincristine)
• Apremilast
• Aprepitant
• Aripiprazole
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• benzodiazepines (e.g., Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam)
• Bisoprolol
• Buprenorphine
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Carbamazepine
• chloroquine
• Clozapine
• Cobicistat
• Codeine
• conivaptan
• cyclosporine
• Dantrolene
• Dapsone
• Darifenacin
• Dexamethasone
• Digoxin
• Disopyramide
• Dronedarone
• Eltrombopag
• Enzalutamide
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Everolimus
• Fentanyl
• Fesoterodine
• Flibanserin
• Gemfibrozil
• "gliptin" Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• glyburide
• grapefruit juice
• Guanfacine
• Haloperidol
• Hepatitis C antiviral medications (e.g., daclatasvir, elbasvir, grazoprevir, ledipasvir, sofosbuvir, velpatasvir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• hormonal birth control (e.g., tablets, injections, patches, implants)
• Hydrocodone
• Leflunomide
• lidocaine
• Lomitapide
• Losartan
• Lurasidone
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Macitentan
• maraviroc
• Mefloquine
• Meperidine
• Methadone
• mifepristone
• milk thistle
• Mirtazapine
• Modafinil
• Naloxegol
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• Ondansetron
• Oxycodone
• Perampanel
• phosphodiesterase-5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• Pimozide
• praziquantel
• Primaquine
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• protein kinase inhibitors (e.g., Axitinib, Bosutinib, imatinib, Nilotinib, Pazopanib)
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
• Quetiapine
• quinidine
• quinine
• Repaglinide
• rifabutin
• rifampin
• rilpivirine
• Riociguat
• Rivaroxaban
• Romidepsin
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• Sirolimus
• Solifenacin
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tacrolimus
• Tamoxifen
• Teriflunomide
• Tetracycline
• Theophylline
• Ticagrelor
• Ticlopidine
• Tolterodine
• Tolvaptan
• Tramadol
• Trazodone
• Ulipristal
• Venlafaxine
• Warfarin
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Tracleer (Bosentan). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.