Xtandi (Enzalutamide) belongs to the class of medications called antineoplastic endocrine therapies. Specifically, Xtandi (Enzalutamide) is an androgen receptor inhibitor. Xtandi (Enzalutamide) is used to treat Prostate Cancer. Androgens are male hormones and include testosterone. Prostate cancer cells require testosterone in order to grow and reproduce. Xtandi (Enzalutamide) blocks the action of male hormones such as testosterone that tell the cancer cells to grow. This slows the growth of prostate cancer.

Xtandi (Enzalutamide) may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Xtandi (Enzalutamide) may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking Xtandi (Enzalutamide) without consulting your doctor.

Do not give Xtandi (Enzalutamide) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

The recommended adult dose of Xtandi (Enzalutamide) is 160 mg (four 40 mg capsules) taken once daily as a single dose. Xtandi (Enzalutamide) may be taken with food or on an empty stomach. Swallow the capsules whole, with water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Xtandi (Enzalutamide) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Xtandi (Enzalutamide). If you are concerned about side effects, discuss the risks and benefits of Xtandi (Enzalutamide) with your doctor.

The following side effects have been reported by at least 1% of people taking Xtandi (Enzalutamide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• anxiety
• back or joint pain
• Constipation
• decreased appetite
• Diarrhea
• dizziness or spinning sensation
• drowsiness
• dry, itchy skin
• falls
• fatigue
• flu-like symptoms (sudden lack of energy, Fever, cough, sore throat)
• forgetfulness
• headache
• hot flush
• nausea
• Restless Leg Syndrome (i.e., uncontrollable urge to move part of the body – usually legs)
• skin rash
• vomiting
• weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• bone fractures
• breast enlargement
• bruising
• difficulty remembering
• difficulty solving problems
• falls
• hallucinations (e.g., seeing or hearing things that aren't there)
• increased blood pressure
• nosebleeds
• problems concentrating
• Shingles (e.g., painful, blistering rash on one side of the body)
• signs of heart problems (e.g., fast, irregular heartbeat or pulse; chest pain; sudden weight gain; difficulty breathing; leg swelling)
• signs of infection (e.g., fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• seizures
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
• signs of posterior reversible encephalopathy syndrome (PRES: e.g., headache, seizures, visual disturbances, altered mental state)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Xtandi (Enzalutamide).

Each white-to-off-white, oblong, liquid-filled, soft capsule with the letters "ENZ" printed in black, contains 40 mg of Xtandi (Enzalutamide). Nonmedicinal ingredients: caprylocaproyl macrogolglycerides, butylhydroxyanisole (E320), butylhydroxytoluene (E321); capsule shell: gelatin, sorbitol sorbitan solution, glycerol, titanium dioxide (E171), and purified water; printing ink: ethanol, ethyl acetate, propylene glycol, iron oxide black (E172), polyvinyl acetate phthalate, purified water, isopropyl, alcohol, macrogol 400, and ammonia solution concentrated.

Do not take Xtandi (Enzalutamide) if you:

• are allergic to Xtandi (Enzalutamide) or any ingredients of the medication
• are breast-feeding
• are or may be pregnant

There may be an interaction between Xtandi (Enzalutamide) and any of the following:

• Abiraterone acetate
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• Amiodarone
• antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Apalutamide
• Apixaban
• Apremilast
• Aprepitant
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• benzodiazepines (e.g., Clobazam, Clonazepam, Diazepam, Lorazepam)
• Bisoprolol
• Bosentan
• Buprenorphine
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, verapamil)
• cancer medications (e.g., docetaxel, Doxorubicin, Etoposide, Ifosfamide, Vinblastine, Vincristine)
• cannabis
• Carbamazepine
• Celecoxib
• chloroquine
• clindamycin
• Clopidogrel
• Cobicistat
• conivaptan
• corticosteroids (e.g., Dexamethasone, Hydrocortisone, Methylprednisolone, Prednisone)
• Cyclosporine
• Dantrolene
• Dapsone
• Darifenacin
• Deferasirox
• Diclofenac
• Disopyramide
• Dronedarone
• Eltrombopag
• Eplerenone
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• estrogens (e.g., Estradiol, ethinyl estradiol)
• Ethosuximide
• Everolimus
• Exemestane
• Flutamide
• fosaprepitant
• Gemfibrozil
• "gliptin" diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• Guanfacine
• Hepatitis C antivirals (e.g., asunaprevir, daclatasvir, dasabuvir, ledipasvir, paritaprevir, ombitasvir, sofosbuvir)
• HIV non-nucleoside reverse transcriptase inhibitors (e.g., efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• isosorbide dinitrate or mononitrate
• Ivabradine
• Ivacaftor
• Leflunomide
• lidocaine
• Losartan
• Macitentan
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• maraviroc
• mefloquine
• Methadone
• Mirtazapine
• Modafinil
• Naloxegol
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• Ondansetron
• Oxcarbazepine
• Perampanel
• Phenobarbital
• Phenytoin
• praziquantel
• Primaquine
• primidone
• progestins (e.g., Norethindrone, norgestrel, medroxyprogesterone)
• protein kinase inhibitors (e.g., Bosutinib, Dasatinib, imatinib, Nilotinib)
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
• quinidine
• quinine
• Repaglinide
• rifabutin
• rifampin
• rilpivirine
• Rivaroxaban
• Roflumilast
• Romidepsin
• Sarilumab
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• Sildenafil
• Silodosin
• siltuximab
• siponimod
• Sirolimus
• Solifenacin
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• St. John's wort
• sulfonylureas (e.g., Glyburide, Gliclazide)
• suvorexant
• tacrolimus
• Tadalafil
• Teriflunomide
• Tetracycline
• Ticlopidine
• Ticagrelor
• Tocilizumab
• Tolterodine
• Tolvaptan
• Tramadol
• Trazodone
• Warfarin
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Xtandi (Enzalutamide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.