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Astellas Pharma

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What is Xtandi?

Xtandi (Enzalutamide) belongs to the class of medications called antineoplastic endocrine therapies. Specifically, Xtandi (Enzalutamide) is an androgen receptor inhibitor.

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Xtandi (Enzalutamide) belongs to the class of medications called antineoplastic endocrine therapies. Specifically, Xtandi (Enzalutamide) is an androgen receptor inhibitor. Xtandi (Enzalutamide) is used to treat Prostate Cancer. Androgens are male hormones and include testosterone. Prostate cancer cells require testosterone in order to grow and reproduce. Xtandi (Enzalutamide) blocks the action of male hormones such as testosterone that tell the cancer cells to grow. This slows the growth of prostate cancer.

Xtandi (Enzalutamide) may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Xtandi (Enzalutamide) may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking Xtandi (Enzalutamide) without consulting your doctor.

Do not give Xtandi (Enzalutamide) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.



The recommended adult dose of Xtandi (Enzalutamide) is 160 mg (four 40 mg capsules) taken once daily as a single dose. Xtandi (Enzalutamide) may be taken with food or on an empty stomach. Swallow the capsules whole, with water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Xtandi (Enzalutamide) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Xtandi (Enzalutamide). If you are concerned about side effects, discuss the risks and benefits of Xtandi (Enzalutamide) with your doctor.

The following side effects have been reported by at least 1% of people taking Xtandi (Enzalutamide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • anxiety
  • back or joint pain
  • Constipation
  • decreased appetite
  • Diarrhea
  • dizziness or spinning sensation
  • drowsiness
  • dry, itchy skin
  • falls
  • fatigue
  • flu-like symptoms (sudden lack of energy, Fever, cough, sore throat)
  • forgetfulness
  • headache
  • hot flush
  • nausea
  • Restless Leg Syndrome (i.e., uncontrollable urge to move part of the body – usually legs)
  • skin rash
  • vomiting
  • weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bone fractures
  • breast enlargement
  • bruising
  • difficulty remembering
  • difficulty solving problems
  • falls
  • hallucinations (e.g., seeing or hearing things that aren't there)
  • increased blood pressure
  • nosebleeds
  • problems concentrating
  • Shingles (e.g., painful, blistering rash on one side of the body)
  • signs of heart problems (e.g., fast, irregular heartbeat or pulse; chest pain; sudden weight gain; difficulty breathing; leg swelling)
  • signs of infection (e.g., fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • seizures
  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
  • signs of posterior reversible encephalopathy syndrome (PRES: e.g., headache, seizures, visual disturbances, altered mental state)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Xtandi (Enzalutamide).


Available form

Each white-to-off-white, oblong, liquid-filled, soft capsule with the letters "ENZ" printed in black, contains 40 mg of Xtandi (Enzalutamide). Nonmedicinal ingredients: caprylocaproyl macrogolglycerides, butylhydroxyanisole (E320), butylhydroxytoluene (E321); capsule shell: gelatin, sorbitol sorbitan solution, glycerol, titanium dioxide (E171), and purified water; printing ink: ethanol, ethyl acetate, propylene glycol, iron oxide black (E172), polyvinyl acetate phthalate, purified water, isopropyl, alcohol, macrogol 400, and ammonia solution concentrated.



Do not take Xtandi (Enzalutamide) if you:

  • are allergic to Xtandi (Enzalutamide) or any ingredients of the medication
  • are breast-feeding
  • are or may be pregnant



There may be an interaction between Xtandi (Enzalutamide) and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Xtandi (Enzalutamide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Xtandi (Enzalutamide).

Abnormal heart rhythms: Xtandi (Enzalutamide) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Xtandi (Enzalutamide). You are more at risk for this type of abnormal heart rhythm and its complications if you:

  • are female
  • are older than 65 years of age
  • have a family history of sudden cardiac death
  • have a history of heart disease or abnormal heart rhythms
  • have a slow heart rate
  • have congenital prolongation of the QT interval
  • have Diabetes
  • have had a Stroke
  • have low potassium, magnesium, or calcium levels
  • have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or if you are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Xtandi (Enzalutamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xtandi (Enzalutamide), and whether any special monitoring is needed.

Blood disorders: Xtandi (Enzalutamide) can cause the levels of certain blood cells to drop. This may lead to problems with blood clotting, or the immune system. Contact your doctor immediately if you develop a fever, chills, easy bruising, or bleeding (symptoms may include black and tarry stools, blood in the urine, or cuts that won't stop bleeding) while taking this medication. Your doctor will arrange periodic blood testing to monitor various blood components.

Blood pressure: Xtandi (Enzalutamide) may cause high blood pressure. Your doctor should monitor your blood pressure regularly while you are taking this medication.

Bone health/fractures: Xtandi (Enzalutamide) may increase the risk of bone fractures. If you have Osteoporosis or bone loss, discuss with your doctor how Xtandi (Enzalutamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xtandi (Enzalutamide), and whether any special monitoring is needed.

Fructose intolerance: Xtandi (Enzalutamide) contains sorbitol. People who have rare hereditary fructose intolerance problems should not take Xtandi (Enzalutamide).

Heart problems: Xtandi (Enzalutamide) may cause or worsen symptoms of heart disease. If you have heart disease or risk factors for developing heart disease, such as high blood pressure, diabetes, or high levels of fat in the blood (High Cholesterol or triglycerides), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xtandi (Enzalutamide), and whether any special monitoring is needed.

Posterior Reversible Encephalopathy Syndrome: Very rarely, Xtandi (Enzalutamide) can cause a reversible brain problem called PRES (posterior reversible encephalopathy syndrome). If you develop a seizure, headache, weakness, confusion, loss of vision, or other vision changes while using this medication, get immediate medical attention.

Reduced alertness: Xtandi (Enzalutamide) may affect the mental abilities needed to drive or operate machinery, such as concentration, problem solving, and focused attention. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how Xtandi (Enzalutamide) affects you.

Seizures: There have been reports of seizures occurring with Xtandi (Enzalutamide). Seizures are more likely to occur when higher doses of this medication are taken or when people have previously taken Docetaxel. If you have a history of Epilepsy or medical conditions that increase the risk of seizures, discuss with your doctor how Xtandi (Enzalutamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: Xtandi (Enzalutamide) should not be used by women. It is not known if Xtandi (Enzalutamide) is found in semen. If you are engaged in sexual activity with a pregnant woman, a condom should be used. If you are engaged in sexual activity with a woman who may become pregnant, you should use a condom and a second effective method of birth control. Condoms must be used during treatment with Xtandi (Enzalutamide) and for 3 months after treatment has ended to avoid possible contact between a developing fetus and the medication. To prevent accidental exposure to Xtandi (Enzalutamide), women who handle these tablets should wear gloves.

Breast-feeding: Xtandi (Enzalutamide) should not be used by women. It is not known if Xtandi (Enzalutamide) passes into breast milk. To prevent accidental exposure to Xtandi (Enzalutamide), women who handle these tablets should wear gloves.

Children: The safety and effectiveness of using Xtandi (Enzalutamide) have not been established for children.

Xtandi frequently asked questions

How To Buy Xtandi Online?

You can buy Xtandi online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Xtandi?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Xtandi in Canada?

Shipping cost for Xtandi to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Xtandi delivered to my home?

You could get Xtandi delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Xtandi in Canada for free?

You can get Xtandi for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Xtandi for free.

Can I consult a doctor online to get Xtandi?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Xtandi.

Can I buy Xtandi without a prescription?

You need a valid prescription to buy Xtandi from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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