Tafinlar (Dabrafenib) belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the family of medications called protein kinase inhibitors. It is used alone or with the medication Trametinib to treat a specific type of Melanoma (Skin Cancer) that cannot be surgically removed or has metastasized (spread to other parts of the body). It is also used after surgery for melanoma to prevent the melanoma from coming back. Tafinlar (Dabrafenib) is also used in combination with trametinib to treat a specific type of non-small cell Lung Cancer (NSCLC) that has metastasized.

Tafinlar (Dabrafenib) is not appropriate for all types of melanoma or NSCLC. It will only interfere with the growth of skin cancer cells that have a particular genetic mutation in a gene called BRAF V600. Your doctor will check for this mutation before Tafinlar (Dabrafenib) is prescribed.

Tafinlar (Dabrafenib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Tafinlar (Dabrafenib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Tafinlar (Dabrafenib) may not be used for all of the conditions discussed here.

Your doctor may have suggested Tafinlar (Dabrafenib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Tafinlar (Dabrafenib), speak to your doctor. Do not stop taking Tafinlar (Dabrafenib) without consulting your doctor.

Do not give Tafinlar (Dabrafenib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Tafinlar (Dabrafenib) if their doctor has not prescribed it.

The recommended adult dose of Tafinlar (Dabrafenib) is 150 mg (2x75 mg capsules) taken by mouth two times a day for a total of 300 mg daily. Tafinlar (Dabrafenib) should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal and with approximately 12 hours between doses. Swallow the capsules whole with a full glass of water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Tafinlar (Dabrafenib) exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 6 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Tafinlar (Dabrafenib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Tafinlar (Dabrafenib). If you are concerned about side effects, discuss the risks and benefits of Tafinlar (Dabrafenib) with your doctor.

The following side effects have been reported by at least 1% of people taking Tafinlar (Dabrafenib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• acne-like skin condition
• Constipation
• cough
• decreased appetite
• Diarrhea
• Dry Mouth
• dry skin
• hair loss or thinning
• headache
• increased sensitivity of skin to sunlight
• increased sweating
• itching
• lack of energy
• mouth sores or ulcers
• nausea
• nail changes
• rash
• skin tags
• stomach pain
• thickened skin
• tingling, burning pain on palms
• vomiting
• weakness
• weight changes

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blood pressure changes (high or low)
• changes to skin colour, thickness, or texture
• chills
• Fever
• flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
• inflammation inside the nose
• joint or muscle pain
• new lesions on skin
• night sweats
• redness and swelling of fingers, palms, soles of feet
• signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worse when breathing in, coughing, coughing up blood, sweating, or passing out)
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
• signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
• signs and symptoms of changes in heart rhythm including feeling dizzy or faint, seizures, palpitations, or a rapid, pounding, or irregular heartbeat
• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
• symptoms of low sodium levels in the blood (e.g., achy, stiff or uncoordinated muscles, confusion, tiredness, weakness)
• symptoms of lung inflammation (e.g., shortness of breath, cough, fatigue, loss of appetite, unintentional weight loss)
• vision changes (e.g., redness, swelling, blurred vision, eye pain, pain or irritation by light)
• wart-like growths

Stop taking the medication and seek immediate medical attention if any of the following occur:

• fever with chills, dizziness or dehydration, or Low Blood Pressure
• signs of bleeding in the stomach (e.g., bloody, black, or  tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
• signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of Stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tafinlar (Dabrafenib).

50 mg
Each opaque, dark red capsule, monogrammed with "GSTEW" and "50 mg" contains 50 mg of Tafinlar (Dabrafenib) as Tafinlar (Dabrafenib) mesylate. Nonmedicinal ingredients: magnesium stearate, colloidal silicon dioxide, and microcrystalline cellulose. Capsule shells contain hypromellose, red iron oxide (E172), and titanium dioxide (E171). Monogramming ink contains black iron oxide, shellac, and propylene glycol.

75 mg
Each opaque, dark pink capsule, monogrammed with "GSLHF" and "75 mg" contains 75 mg of Tafinlar (Dabrafenib) as Tafinlar (Dabrafenib) mesylate. Nonmedicinal ingredients: magnesium stearate, colloidal silicon dioxide, and microcrystalline cellulose. Capsule shells contain hypromellose, red iron oxide (E172), and titanium dioxide (E171). Monogramming ink contains black iron oxide, shellac, and propylene glycol.

Do not take Tafinlar (Dabrafenib) if you are allergic to Tafinlar (Dabrafenib) or any ingredients of the medication.

There may be an interaction between Tafinlar (Dabrafenib) and any of the following:

• Abiraterone
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• Amiodarone
• amphotericin B
• antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide, sodium bicarbonate)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., Aripiprazole, Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Apalutamide
• Apixaban
• Aprepitant
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• barbiturates (e.g., Phenobarbital, secobarbital)
• benzodiazepines (e.g., Clonazepam, Diazepam, Lorazepam)
• Bicalutamide
• birth control pills (estrogen/progestin)
• Bisoprolol
• Bosentan
• Buprenorphine
• Bupropion
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• cancer medications (e.g., Busulfan, Cyclophosphamide, Tamoxifen, Vinblastine)
• Celecoxib
• chloroquine
• Clopidogrel
• Codeine
• conivaptan
• Cyclosporine
• Cyproterone
• Dantrolene
• Dapsone
• Darifenacin
• Deferasirox
• Degarelix
• Dexamethasone
• diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Rosiglitazone)
• Digoxin
• Disopyramide
• dofetilide
• Domperidone
• Dronedarone
• Eltrombopag
• Enzalutamide
• estrogens (e.g., Estradiol, Estropipate)
• Everolimus
• Fentanyl
• Flecainide
• Flutamide
• Fesoterodine
• Gemfibrozil
• grapefruit juice
• Guanfacine
• H2-antagonists (antacids; e.g., Famotidine, Ranitidine)
• Hepatitis C antivirals (e.g., daclatasvir, dasabuvir, ledipasvir, paritaprevir, ombitasvir, sofosbuvir)
• HIV non-nucleoside reverse transcriptase inhibitors (e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Irbesartan
• isosorbide dinitrate/mononitrate
• lidocaine
• Lomitapide
• Losartan
• lumacaftor
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• maraviroc
• Mefloquine
• Methadone
• Metronidazole
• mifepristone
• Mirtazapine
• Moclobemide
• Modafinil
• Montelukast
• Naloxegol
• nefazodone
• Oxycodone
• pentamidine
• praziquantel
• Primaquine
• procainamide
• progestins (e.g., Levonorgestrel, Progesterone, mestranol)
• Propafenone
• other protein kinase inhibitors (e.g., Bosutinib, Dasatinib, imatinib, Nilotinib)
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole, Pantoprazole)
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• rifabutin
• rifampin
• rilpivirine
• Riociguat
• Rivaroxaban
• Roflumilast
• Romidepsin
• St. John's wort
• Selegiline
• seizure medications (e.g., Carbamazepine, Clobazam, Ethosuximide, Levetiracetam, phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• Sildenafil
• simeprevir
• Sirolimus
• Solifenacin
• Sotalol
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
• Tacrolimus
• Tetrabenazine
• Tetracycline
• Ticagrelor
• Ticlopidine
• Tolterodine
• Tolvaptan
• Tramadol
• Trazodone
• tretinoin
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• Trimethoprim
• Ulipristal
• Venlafaxine
• Warfarin
• Zafirlukast
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Tafinlar (Dabrafenib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.