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Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). In adults and children, it is used to treat conditions such as reflux esophagitis (tissue damage caused by stomach contents flowing back up the esophagus) and symptoms of GERD (Gastroesophageal reflux disease) (GERD) in people with reflux esophagitis.
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Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). In adults and children, it is used to treat conditions such as reflux esophagitis (tissue damage caused by stomach contents flowing back up the esophagus) and symptoms of GERD (Gastroesophageal reflux disease) (GERD) in people with reflux esophagitis. It is also used to treat nonerosive reflux disease (NERD; heartburn and regurgitation not related to tissue damage) in children and adults. When combined with other medications, esomeprazole is used to treat duodenal ulcers that are caused by bacteria known as H. pylori.
Esomeprazole can be used to treat or reduce the risk of stomach ulcers due to medications known as NSAIDs (e.g., Ibuprofen, Naproxen, Ketorolac) that irritate the stomach. It is also used to treat conditions associated with the overproduction of stomach acid, including Zollinger-Ellison syndrome.
Esomeprazole works by reducing the amount of acid the stomach produces.
Ran Esomeprazole may be available under multiple brand names and/or in several different forms. Any specific brand name of Ran Esomeprazole may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Ran Esomeprazole may not be used for all of the conditions discussed here.
Your doctor may have suggested Ran Esomeprazole for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Ran Esomeprazole, speak to your doctor. Do not stop taking Ran Esomeprazole without consulting your doctor.
Do not give Ran Esomeprazole to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Ran Esomeprazole if their doctor has not prescribed it.
The recommended dose of esomeprazole to treat reflux esophagitis and symptoms of GERD is 40 mg once daily for 4 to 8 weeks. After 8 weeks, treatment may be continued at a dose of 20 mg once daily.
To treat NERD or heartburn, the recommended dose is 20 mg taken once daily for 2 to 4 weeks. After this, esomeprazole may be taken at a dose of 20 mg once daily as needed to control symptoms.
To treat stomach ulcers associated with NSAID use, the dose is 20 mg once daily for 4 to 8 weeks. To prevent such ulcers, the dose is 20 mg once daily.
To treat duodenal ulcers caused by H. pylori in adults, the dose of esomeprazole is 20 mg twice daily taken with amoxicillin 1,000 mg twice daily and clarithromycin 500 mg twice daily - all for 7 days.
The initial dose to treat acid over-production with Zollinger-Ellison Syndrome, is 40 mg taken by mouth, twice a day. The dose that relieves the over-secretion of acid varies depending on the person.
For children 12 months to 11 years of age, the recommended dose of esomeprazole to treat reflux esophagitis is 10 mg to 20 mg (depending on the child's weight) once daily for 8 weeks. For NERD (heartburn and reflux), the recommended dose is 10 mg once daily for up to 8 weeks.
For children 11 to 17 years of age, the recommended dose of esomeprazole to treat reflux esophagitis is 20 mg to 40 mg once daily for 4 to 8 weeks. For NERD (heartburn and reflux), the recommended dose is 20 mg once daily for 2 to 4 weeks.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Esomeprazole tablets can be taken with or without food. They should be swallowed whole - do not crush or chew them. Alternatively, the tablet may be stirred into half a glass of noncarbonated water until it disintegrates. Drink the liquid containing the small pellets of medication immediately, or within 30 minutes. To ensure you get the full dose of the medication, rinse the glass with more water and drink it.
The sachets of esomeprazole contain granules for oral suspension. Pour all the granules of one sachet into a glass containing one tablespoon (15 mL) of water, stir, and leave for a few minutes to allow the mixture to thicken. Stir again and drink it within 30 minutes. To ensure you get the full dose of the medication, rinse the glass with more water and drink it.
It is important to take Ran Esomeprazole exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Ran Esomeprazole at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Ran Esomeprazole. If you are concerned about side effects, discuss the risks and benefits of Ran Esomeprazole with your doctor.
The following side effects have been reported by at least 1% of people taking Ran Esomeprazole. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ran Esomeprazole.
Each light-brick-red-to-brown, oval, biconvex, film-coated tablet, with "E5" debossed on one side, contains 20 mg of esomeprazole. Nonmedicinal ingredients: crospovidone, diethyl phthalate, hydroxy propyl cellulose, hypromellose, hypromellose phthalate, iron oxide red, macrogol 400, macrogol 4000, macrogol 6000, microcrystalline cellulose, povidone, sodium stearyl fumarate, sugar spheres (sucrose and maize starch), talc, and titanium dioxide.
Each light-brick-red-to-brown, oval, biconvex, film-coated tablet with "E6" debossed on one side contains 40 mg of esomeprazole. Nonmedicinal ingredients: crospovidone, diethyl phthalate, hydroxy propyl cellulose, hypromellose, hypromellose phthalate, iron oxide red, macrogol 400, macrogol 4000, macrogol 6000, microcrystalline cellulose, povidone, sodium stearyl fumarate, sugar spheres (sucrose and maize starch), talc, and titanium dioxide.
Do not take Ran Esomeprazole if you:
There may be an interaction between esomeprazole and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Ran Esomeprazole. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ran Esomeprazole.
Bone health: Studies suggest that the use of esomeprazole, like other PPIs, may be related to an increase risk of fractures, particularly for people who take Ran Esomeprazole for a year or longer. The lowest dose of Ran Esomeprazole to control the symptoms, taken for the shortest period of time, is less likely to cause these problems.
Diarrhea: When gastric acid is decreased, the number of bacteria normally in the digestive system increases. Occasionally, this can cause serious infection in the digestive tract. If you experience watery, foul-smelling bowel movements after starting to take esomeprazole, contact your doctor as soon as possible.
Fluid and electrolyte balance: Esomeprazole may cause the levels of electrolytes such as potassium, magnesium, and calcium in the blood to change while taking Ran Esomeprazole. If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; dry mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible.
Liver function: The liver is partially responsible for removing esomeprazole from the body. Liver disease or reduced liver function may cause Ran Esomeprazole to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Ran Esomeprazole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ran Esomeprazole, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Ran Esomeprazole.
Methotrexate interaction: Esomeprazole, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, Anemia, or infection. If you take esomeprazole and are also going to receive a dose of methotrexate, discuss with your doctor how Ran Esomeprazole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ran Esomeprazole, and whether any special monitoring is needed.
More serious conditions of the stomach and intestines: If you experience symptoms of a more serious condition of the stomach and intestines (e.g., trouble swallowing, unplanned weight loss, persistent vomiting, vomiting blood, or black stools) while taking Ran Esomeprazole, contact your doctor immediately.
Subacute cutaneous Lupus erythematosus (SCLE): Esomeprazole, like other PPIs, has been rarely associated with SCLE, an autoimmune disease. If you develop any skin lesions, especially in sun-exposed skin areas, and if accompanied by muscle aches or pains, contact your doctor immediately.
Vitamin B12: Long-term use of esomeprazole may lead to vitamin B12 deficiency. If you are a vegetarian or have low vitamin B12 levels, discuss with your doctor whether any special monitoring is required.
Pregnancy: Ran Esomeprazole should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Ran Esomeprazole, contact your doctor immediately.
Breast-feeding: It is not known if esomeprazole passes into breast milk. If you are a breast-feeding mother and are taking Ran Esomeprazole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Ran Esomeprazole have not been established for children less than 1 year of age.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
August 8, 2022
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