Bosulif

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Available Form:  

TABLET

Manufacturer name:  

Pfizer

Generic name:  

BOSUTINIB

Strength:  

100MG

What is Bosulif?

Bosulif (Bosutinib) belongs to a family of medications called protein tyrosine kinase inhibitors. It is used to treat adults with certain types of chronic myelogenous Leukemia (CML) in blast crisis (sudden attack), accelerated phase (fast growth), or in chronic phase (long-term illness).

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Bosulif 

Indication

Bosulif (Bosutinib) belongs to a family of medications called protein tyrosine kinase inhibitors. It is used to treat adults with certain types of chronic myelogenous Leukemia (CML) in blast crisis (sudden attack), accelerated phase (fast growth), or in chronic phase (long-term illness). Bosulif (Bosutinib) may be used when other tyrosine kinase inhibitors have not worked or been tolerated and they are not appropriate for ongoing treatment.

Bosulif (Bosutinib) works by affecting enzymes that play a role in certain cancer cells to reduce the growth and spread of the cancer cells.

Bosulif (Bosutinib) has been granted a notice of compliance with conditions (NOC/c) by Health Canada. This means that Health Canada has approved Bosulif (Bosutinib) to be marketed based on promising evidence of effectiveness, but additional results of studies are needed to verify its effectiveness. An NOC/c is used to allow access to products that are used to treat or prevent serious, life-threatening, or severely debilitating illness.

Bosulif (Bosutinib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Bosulif (Bosutinib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Bosulif (Bosutinib) may not be used for all of the conditions discussed here.

Your doctor may have suggested Bosulif (Bosutinib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Bosulif (Bosutinib), speak to your doctor. Do not stop taking Bosulif (Bosutinib) without consulting your doctor.

Do not give Bosulif (Bosutinib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Bosulif (Bosutinib) if their doctor has not prescribed it.

Bosulif 

Dosage

The recommended adult dose of Bosulif (Bosutinib) is 500 mg taken by mouth, once a day. It should be swallowed whole with water, and taken with a meal. Do not crush or cut the tablets.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Bosulif (Bosutinib) be taken exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Bosulif (Bosutinib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Bosulif 

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Bosulif (Bosutinib). If you are concerned about side effects, discuss the risks and benefits of Bosulif (Bosutinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Bosulif (Bosutinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • Acne
  • changed sense of taste
  • decreased appetite
  • Diarrhea
  • fatigue
  • headache
  • itchy skin
  • joint pain
  • nausea
  • skin rash
  • stomach pain
  • vomiting
  • weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abnormal heart rhythms (such as fast or slow heart rate, palpitations), fainting, or seizures
  • dizziness
  • Fever
  • generalized pain (back pain, muscle pain)
  • increased blood pressure shortness of breath
  • signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of bleeding (e.g., bloody nose, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
  • signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
  • signs of fluid build-up around the lungs (e.g., chest pain, cough, hiccups, rapid breathing)
  • signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of kidney failure (e.g., decreased urine production, swelling, fatigue, abdominal pain)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of pneumonia (e.g., fever, chills, shortness of breath, cough)
  • swelling of the hands, feet or face
  • symptoms of fluid build-up around the heart (e.g., fever, fatigue, muscle aches, shortness of breath, nausea, vomiting, diarrhea, fast or pounding heart beat, light-headedness)
  • symptoms of too much potassium in the body (e.g., muscle fatigue, weakness, difficulty moving, abnormal heart rhythms, nausea)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Bosulif (Bosutinib).

Bosulif 

Available form

100 mg
Each yellow, oval, biconvex, film-coated tablet debossed with "Pfizer" on one side and "100" on the other, contains 103.40 mg of Bosulif (Bosutinib) monohydrate, equivalent to 100 mg of Bosulif (Bosutinib). Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, poloxamer, povidone, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide yellow.

500 mg
Each red, oval, biconvex, film-coated tablet debossed with "Pfizer" on one side and "500" on the other, contains 516.98 mg of Bosulif (Bosutinib) monohydrate, equivalent to 500 mg of Bosulif (Bosutinib). Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, poloxamer, povidone, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide red.

Bosulif 

Contraindications

Do not take Bosulif (Bosutinib) if you:

  • are allergic to Bosulif (Bosutinib) or any ingredients of the medication
  • have a history of irregular heartbeat, particularly long QT syndrome
  • have untreated low potassium or low magnesium in your blood
  • have reduced liver function

Bosulif 

Precautions

There may be an interaction between Bosulif (Bosutinib) and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Bosulif (Bosutinib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Bosulif 

Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Bosulif (Bosutinib).

HEALTH CANADA ADVISORY

May 4, 2016

Health Canada has issued new restrictions concerning the use of Bosulif (Bosulif (Bosutinib)). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Abnormal heart rhythms: Bosulif (Bosutinib) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, droperidol, Pimozide, , moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Bosulif (Bosutinib). You are more at risk for this type of abnormal heart rhythm and its complications if you:

  • are female
  • are older than 65 years of age
  • have a family history of sudden cardiac death
  • have a history of heart disease or abnormal heart rhythms
  • have a slow heart rate
  • have congenital prolongation of the QT interval
  • have Diabetes
  • have had a Stroke
  • have low potassium, magnesium, or calcium levels
  • have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or people are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed.

Anemia: Bosulif (Bosutinib) may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired or pale skin, contact your doctor as soon as possible.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.

Birth control: Effective birth control should be practiced while using Bosulif (Bosutinib) as Bosulif (Bosutinib) may harm the baby if used during pregnancy. Both men and women should use effective birth control (e.g., condoms, birth control pill) during treatment and for at least 4 weeks after treatment is finished. If you or your partner become pregnant while taking Bosulif (Bosutinib), contact your doctor immediately.

Bleeding: Bosulif (Bosutinib) may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.

Bone health: People who take Bosulif (Bosutinib) may be at an increased risk of bone fractures as a result of a decrease in the density and strength of bones. This effect is more likely to occur with people who have Osteoporosis or have changes in minerals in the blood or hormones that affect how the body retains calcium. If you have osteoporosis or risk factors for osteoporosis (female, small stature, over age 65, long-term use of corticosteroids or certain other medications), discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed.

Drowsiness/reduced alertness: Bosulif (Bosutinib) is not expected to make you drowsy and impair your ability to drive or use machinery. However, it may make some people feel weak. Do not drive or use machinery until you know how Bosulif (Bosutinib) affects you.

Dehydration: Severe dehydration can occur with the use of Bosulif (Bosutinib). This may be due to severe or persistent diarrhea, vomiting, or decreased fluid intake. Dehydration can lead to kidney failure, if it is severe enough. While you are taking Bosulif (Bosutinib), you may be encouraged to drink extra water. Your doctor will do blood tests to check the function of your kidneys.

Fluid retention: Bosulif (Bosutinib) can cause serious fluid retention. If you experience unexpected rapid weight gain or swelling in your feet, ankles, lower legs, or hands, contact your doctor immediately. Your doctor will weigh and monitor you regularly for signs of fluid retention while you are taking Bosulif (Bosutinib).

Gastrointestinal bleeding: Bosulif (Bosutinib) can cause bleeding in the digestive system. This is very serious and sometimes fatal. If you experience signs of bleeding from the stomach or intestines, such as vomiting blood or material that looks like coffee grounds, or stools that are black and tarry get immediate medical attention.

Grapefruit juice, star fruit, and pomegranate: Grapefruit and grapefruit juice, star fruit, and pomegranate all affect how Bosulif (Bosutinib) is removed from the body and may cause too much of the medication to build up in the body. Avoid these foods and juices while you are taking Bosulif (Bosutinib).

Heart problems and heart failure: If you are at risk for heart problems such as heart failure (e.g., if you have high blood pressure, diabetes, or Coronary Artery Disease), discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed. Contact your doctor immediately if you have symptoms of heart failure such as leg swelling, chest pain, or shortness of breath.

Hepatitis B: People who have chronic (long-term) hepatitis B may experience a flare-up of hepatitis B symptoms when they take Bosulif (Bosutinib). In severe cases, this can cause liver failure, may necessitate a liver transplant, or may even be fatal. If you have a history of hepatitis B, discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed.

Infection: As well as killing cancer cells, Bosulif (Bosutinib) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Decreased kidney function or Kidney Disease may cause Bosulif (Bosutinib) to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed.

Rarely, Bosulif (Bosutinib) has been reported to cause kidney failure. If you experience signs of decreasing kidney function such as decreased urine production, swelling, fatigue or abdominal pain, contact your doctor immediately.

Liver function: Liver disease or reduced liver function may cause Bosulif (Bosutinib) to build up in the body, causing side effects. If you have reduced liver function or liver disease, discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed.

Bosulif (Bosutinib) has been reported to cause liver failure, which can cause death.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pancreatitis: Bosulif (Bosutinib) can cause the pancreas to become inflamed. If you have a history of pancreatitis, discuss with your doctor how Bosulif (Bosutinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Bosulif (Bosutinib), and whether any special monitoring is needed.

Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your doctor immediately.

If you have a history of pancreatitis, gallstones, Alcoholism, or high triglycerides, you may be more at risk of experiencing this.

Skin reactions: Severe skin reactions have been linked to Bosulif (Bosutinib) use. Although rare, they are considered medical emergencies and require immediate medical attention.

If you experience skin blistering or peeling, a rash that covers a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort, seek medical attention immediately.

Tumour lysis syndrome: Bosulif (Bosutinib), like many other cancer medications, causes many cancer cells to be suddenly killed when treatment is first started. This can overwhelm the body with waste products from the cells. As a result, the body may not be able to keep up with getting rid of all the waste. When this happens, you may have nausea, shortness of breath, cloudy urine, or joint pain. This is called tumour lysis syndrome. Your doctor may prescribe some medications to help your body get rid of the waste products. Make sure you understand how to use these medications and report any of these signs or symptoms to your doctor immediately.

Pregnancy: Bosulif (Bosutinib) should not be taken during pregnancy. Bosulif (Bosutinib) may cause severe harm to a developing baby if it is taken by the mother while she is pregnant. Female partners of men taking Bosulif (Bosutinib) should not become pregnant. Both females and males must use a reliable method of birth control (e.g., condoms, birth control pill) during treatment and for at least 4 weeks after treatment is finished. If you become pregnant while taking Bosulif (Bosutinib), contact your doctor immediately.

Breast-feeding: Bosulif (Bosutinib) passes into breast milk. If you are a breast-feeding mother and are taking Bosulif (Bosutinib), it may affect your baby.  Due to the potential for serious harm to a baby if they are exposed to Bosulif (Bosutinib), breast-feeding mothers are advised not use Bosulif (Bosutinib).

Children: The safety and effectiveness of Bosulif (Bosutinib) have not been established for children.

Bosulif frequently asked questions

How To Buy Bosulif Online?

You can buy Bosulif online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Bosulif?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Bosulif in Canada?

Shipping cost for Bosulif to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Bosulif delivered to my home?

You could get Bosulif delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Bosulif in Canada for free?

You can get Bosulif for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Bosulif for free.

Can I consult a doctor online to get Bosulif?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Bosulif.

Can I buy Bosulif without a prescription?

You need a valid prescription to buy Bosulif from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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