Sprycel (Dasatinib) belongs to the class of medications called protein-tyrosine kinase inhibitors. Sprycel (Dasatinib) works by inhibiting the activity of proteins that are responsible for the uncontrolled growth of Leukemia cells. By inhibiting these proteins, Sprycel (Dasatinib) kills the leukemia cells in the bone marrow and allows normal blood cells to be produced.

It is used to treat adults with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML). It is also used to treat adults with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) who have not responded or tolerated other treatments.

Sprycel (Dasatinib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Sprycel (Dasatinib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Sprycel (Dasatinib) may not be used for all of the conditions discussed here.

Your doctor may have suggested Sprycel (Dasatinib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Sprycel (Dasatinib), speak to your doctor. Do not stop taking Sprycel (Dasatinib) without consulting your doctor.

Do not give Sprycel (Dasatinib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Sprycel (Dasatinib) if their doctor has not prescribed it.

Treatment with Sprycel (Dasatinib) should be started under the direct supervision of a physician experienced in the treatment of the conditions Sprycel (Dasatinib) is used to treat.

For chronic myeloid leukemia (CML), the recommended starting dose of Sprycel (Dasatinib) is 100 mg once daily, either in the morning or in the evening.

For accelerated or blast crisis CML or for Ph+ acute lymphoblastic leukemia (ALL), the recommended starting dose of Sprycel (Dasatinib) is 140 mg once daily, either in the morning or in the evening.

Your dose may be adjusted depending on your response to the medication and on the side effects you experience.

Sprycel (Dasatinib) may be taken with or without food. The tablets should be swallowed whole and should not be crushed or cut. Try to take the medication at the same time each day. Avoid drinking grapefruit juice, as it may increase the blood levels of Sprycel (Dasatinib) and increase the risk of side effects.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use Sprycel (Dasatinib) exactly as prescribed by your doctor. If you miss a dose, take your next scheduled dose at its regular time. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Sprycel (Dasatinib) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Sprycel (Dasatinib). If you are concerned about side effects, discuss the risks and benefits of Sprycel (Dasatinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Sprycel (Dasatinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• cough
• Diarrhea
• fatigue
• Fever
• headache
• inflammation of mucous membranes (e.g., inside the mouth)
• muscle, joint, or bone pain
• nausea
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• dizziness or feeling faint
• fever and chills
• signs of Anemia (low red blood cells; e.g., dizziness, fatigue, pale skin, unusual tiredness or weakness, shortness of breath)
• signs of bleeding (e.g., unusual nosebleeds, bruising, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of fluid retention (rapid weight gain, swelling, increasing shortness of breath)
• signs of infection (fever, severe chills, sore throat, or mouth ulcers)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of muscle damage (e.g., unexpected muscle pain or aches, weakness, dark urine)
• shortness of breath and fatigue
• skin rash
• symptoms of irregular heartbeat (e.g., chest pain, dizziness, rapid, pounding heartbeat, shortness of breath)
• symptoms of Low Blood Pressure (dizziness, lightheadedness)
• unexpected bleeding or bruising without suffering from any injury

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
• symptoms of an allergic reaction (Hives; difficulty breathing; wheezing; swelling of lips, mouth, tongue, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Sprycel (Dasatinib).

20 mg
Each white-to-off-white, biconvex, round, film-coated tablet with "BMS" debossed on one side and "527" on the other contains 20 mg of Sprycel (Dasatinib). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and microcrystalline cellulose; film coating: hypromellose, polyethylene glycol, and titanium dioxide.

50 mg
Each white-to-off-white, biconvex, oval, film-coated tablet with "BMS" debossed on one side and "528" on the other contains 50 mg of Sprycel (Dasatinib). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and microcrystalline cellulose; film coating: hypromellose, polyethylene glycol, and titanium dioxide.

70 mg
Each white-to-off-white, biconvex, round, film-coated tablet with "BMS" debossed on one side and "524" on the other contains 70 mg of Sprycel (Dasatinib). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and microcrystalline cellulose; film coating: hypromellose, polyethylene glycol, and titanium dioxide.

80 mg
Each white-to-off-white, biconvex, triangular, film-coated tablet with "BMS" over "80" debossed on one side and "855" on the other side contains 80 mg of Sprycel (Dasatinib). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and microcrystalline cellulose; film coating: hypromellose, polyethylene glycol, and titanium dioxide.

100 mg
Each white-to-off-white, biconvex, oval, film-coated tablet with "BMS 100" debossed on one side and "852" on the other side contains 100 mg of Sprycel (Dasatinib). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and microcrystalline cellulose; film coating: hypromellose, polyethylene glycol, and titanium dioxide.

140 mg
Each white-to-off-white, biconvex, round, film-coated tablet with "BMS" over "140" debossed on one side and "857" on the other side contains 140 mg of Sprycel (Dasatinib). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and microcrystalline cellulose; film coating: hypromellose, polyethylene glycol, and titanium dioxide.

Do not take Sprycel (Dasatinib) if you are allergic to Sprycel (Dasatinib) or any ingredients of the medication.

There may be an interaction between Sprycel (Dasatinib) and any of the following:

• Abiraterone
• Acetaminophen
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• amiodarone
• antacids containing aluminum or magnesium
• anti-cancer medications (e.g., Cabazitaxel, Docetaxel, doxorubicin, Etoposide, Ifosfamide, Irinotecan, Vincristine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Aprepitant
• Anagrelide
• Apixaban
• Asa
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• barbiturates (e.g., butalbital, pentobarbital, Phenobarbital)
• BCG
• benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
• Bicalutamide
• Bisoprolol
• Bosentan
• Bromocriptine
• Buprenorphine
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Carbamazepine
• chloroquine
• Clopidogrel
• conivaptan
• Cyclosporine
• dabigatran
• Dantrolene
• Dapsone
• Darifenacin
• Deferasirox
• Degarelix
• Denosumab
• Dexamethasone
• Digoxin
• disopyramide
• dofetilide
• Domperidone
• Dronedarone
• droperidol
• Echinacea
• Edoxaban
• Enzalutamide
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Ethosuximide
• Everolimus
• Fingolimod
• Flecainide
• Flutamide
• fusidic acid
• "gliptin" Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• grapefruit juice
• H2-antagonists (e.g., Cimetidine, Ranitidine, Famotidine, Nizatidine)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Heparin
• Hydrocodone
• Indacaterol
• Leflunomide
• lidocaine
• Lomitapide
• Losartan
• low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• maraviroc
• Mefloquine
• mestranol
• Methadone
• Metronidazole
• mifepristone
• Mirtazapine
• Modafinil
• Montelukast
• Natalizumab
• nefazodone
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• Nivolumab
• non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
• Ondansetron
• Oxcarbazepine
• Oxycodone
• Phenytoin
• Pimecrolimus
• Prasugrel
• praziquantel
• Primaquine
• primidone
• procainamide
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• other protein kinase inhibitors (e.g., Bosutinib, Nilotinib, imatinib)
• proton pump inhibitors (e.g., Omeprazole, Rabeprazole, Pantoprazole)
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• Repaglinide
• rifabutin
• rifampin
• rilpivirine
• Rivaroxaban
• Roflumilast
• Romidepsin
• St. John's wort
• salmeterol
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, ondansetron)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• Sildenafil
• siltuximab
• simeprevir
• Sirolimus
• sotalol
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tacrolimus
• Tamoxifen
• Tetrabenazine
• Tetracycline
• Theophylline
• Ticagrelor
• Ticlopidine
• Tocilizumab
• Tofacitinib
• Tolterodine
• Tolvaptan
• Tramadol
• Trastuzumab
• Trazodone
• vaccines
• Warfarin
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Sprycel (Dasatinib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.