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What is Dihydroergotamine?

Dihydroergotamine belongs to a family of medications called ergot alkaloids. It is used to help relieve the pain of migraine Headaches.

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Dihydroergotamine belongs to a family of medications called ergot alkaloids. It is used to help relieve the pain of migraine Headaches. These medications work by constricting blood vessels in the head. This relieves the dilation (widening) of blood vessels, which is related to migraine headache pain.

Dihydroergotamine is most effective if used at the first sign of a migraine headache with or without aura (warning signs that occur prior to the onset of a migraine headache). It is not effective for other types of headache. Relief is often obtained within one-half hour of using the medication. Extra medication may be given if some relief is not obtained after the initial dose. (See the following section for maximum doses.)

Your doctor may have suggested Dihydroergotamine for conditions other than those listed in these drug information articles. As well, some forms of Dihydroergotamine may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are using Dihydroergotamine, speak to your doctor. Do not stop using Dihydroergotamine without consulting your doctor.

Do not give Dihydroergotamine to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Dihydroergotamine if their doctor has not prescribed it.



The recommended dose of dihydroergotamine is one spray in each nostril (total of 2 sprays) at the first sign or symptom of a migraine headache, or as early as possible after the onset of migraine headache pain. If the migraine has not improved sufficiently after about 15 minutes, one additional spray can be used in each nostril (total of 2 more sprays).

One bottle of dihydroergotamine nasal spray contains 4 sprays. No more than 4 sprays (2 in each nostril, i.e., one bottle) should be used for any migraine attack. No more than 8 sprays (2 bottles) should be used in any 24-hour period. No more then 24 sprays (6 bottles) should be used in any 7-day period.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Dihydroergotamine exactly as prescribed by your doctor.

The spray should be used in the following manner (see package insert for illustrated details):

  • Start to prepare the sprayer only when you have a migraine attack.
  • Slowly lift and bend back the lip of the blue seal to show the rubber stopper. Try not to break the blue seal.
  • Completely remove the seal and metal collar in one piece, if possible. If the two should break apart, carefully continue removing the metal collar. The collar has a sharp edge - handle it with care.
  • Gently pull the rubber stopper out of the bottle. Be careful not to spill the contents.
  • Gently remove the transparent plastic protective cover from the bottom of the sprayer. Insert the sprayer into the bottle and tighten firmly onto the bottle in a clockwise direction.
  • Holding the bottle upright, gently remove the blue plastic protective cap from the top of the sprayer.
  • Prior to use, the sprayer must be primed (pumped 4 times in the air).
  • Hold your head straight.
  • Insert the sprayer into one nostril and pump the sprayer once to release the medication. Repeat in the other nostril (a total of 2 sprays).
  • Don't blow your nose.
  • Wait about 15 minutes. If you have not already experienced sufficient relief, or to obtain optimal efficacy and long-lasting relief, repeat the spray once in each nostril. Discard the bottle and sprayer after use or within 8 hours of preparation.
  • Lie down in a quiet, dark room for a while after you use Dihydroergotamine. This may help with your treatment.

Store the product at room temperature.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses Dihydroergotamine. If you are concerned about side effects, discuss the risks and benefits of Dihydroergotamine with your doctor.

The following side effects have been reported by at least 1% of people using Dihydroergotamine. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • anxiety
  • blurred vision
  • burning or tingling sensation, dryness, soreness, or pain in the nose
  • change in taste sensation
  • cold clammy skin
  • confusion
  • congestion in chest, presence of cough
  • decreased appetite
  • Depression
  • Diarrhea
  • difficulty swallowing
  • dizziness
  • dizziness or lightheadedness when rising from a lying or sitting position
  • drowsiness, fatigue, unusual tiredness, or weakness
  • Dry Mouth
  • ear pain
  • eye pain
  • Fever
  • headache
  • heartburn
  • increased sweating, sudden sweating, or feelings of warmth
  • increased watering of eyes
  • increased watering of mouth
  • increased yawning
  • muscle stiffness
  • muscle weakness
  • nausea or vomiting
  • nervousness
  • pinpoint-sized red spots on skin
  • pounding heartbeat
  • red or irritated eyes
  • ringing or buzzing in ears
  • runny or stuffy nose
  • skin rash
  • stomach pain
  • sudden fainting
  • swelling of face, fingers, feet, or lower legs
  • trembling or shaking of hands or feet
  • trouble sleeping
  • unexplained nosebleeds

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Stop using the medication and seek immediate medical attention if any of the following occur:

  • chest pain
  • cough, fever, sneezing, or sore throat
  • feeling of heaviness in chest
  • irregular heartbeat
  • itching of the skin
  • numbness and tingling of face, fingers, or toes
  • pain in arms, legs, or lower back
  • pain in back, chest, or left arm
  • pale bluish-coloured or cold hands or feet
  • shortness of breath or troubled breathing
  • weak or absent pulses in legs

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Dihydroergotamine.


Available form

Each mL of sterile injectable solution contains dihydroergotamine mesylate 1 mg. Nonmedicinal ingredients: anhydrous ethyl alcohol 47 mg, glycerol, methanesulfonic acid to adjust pH and water for injection.



Do not use dihydroergotamine if you:

  • are allergic to any of the ingredients
  • are pregnant
  • are a breast-feeding mother
  • are taking the following medications
    • protease inhibitors (e.g., ritonavir, nelfinavir, indinavir)
    • macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin)
    • antifungal agents (e.g., ketoconazole, itraconazole)
  • have Coronary Artery Disease
  • have diseases of blood circulation
  • have uncontrolled high blood pressure
  • have severely impaired liver function
  • have severely impaired kidney function

There may be other conditions where the doctor may not want you to use Dihydroergotamine. Be sure to tell all health care professionals involved in your care about all your medical conditions.



There may be an interaction between dihydroergotamine and any of the following:

  • antifungal agents (e.g., ketoconazole, itraconazole)
  • cocaine
  • Epinephrine by injection
  • macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin)
  • Naratriptan
  • Nicotine
  • other ergot medications (e.g., methysergide, ergonovine, ergoloid mesylates)
  • protease inhibitors (e.g., ritonavir, nelfinavir, indinavir)
  • Rizatriptan
  • Sumatriptan

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Dihydroergotamine. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Dihydroergotamine.

Dependence: If you take dihydroergotamine for extended periods of time you may become dependent upon it and require progressively increasing doses for relief of headaches or to prevent the increasing unpleasant effects which may follow withdrawal of the medication.

Drowsiness/reduced alertness: You should not undertake activities requiring mental alertness, such as operating equipment or driving a vehicle, until you determine your response and sensitivity to Dihydroergotamine.

Overdose: It is important to stay within the limits of the recommended dosage of Dihydroergotamine and avoid excessive or prolonged use. An overdose of ergotamine is dangerous, and may cause the following effects:

  • cold and pale skin
  • confusion
  • depression
  • diarrhea
  • dizziness
  • drowsiness
  • headache
  • itching
  • muscle pain
  • nausea
  • pain like that of Angina
  • rapid and weak pulse
  • rise and/or fall of blood pressure (usually in that order)
  • slow or fast heart rate
  • thirst
  • tingling and numbness of the extremities
  • unconsciousness
  • vomiting

If an overdose is suspected, seek medical help immediately.

Pregnancy: Dihydroergotamine may cause harm when taken during pregnancy. If you become pregnant while using Dihydroergotamine, contact your doctor immediately.

Breast-feeding: Dihydroergotamine passes into breast milk and may cause symptoms of vomiting, diarrhea, weak pulse, and unstable blood pressure in nursing infants. If you are a breast-feeding mother you should not take Dihydroergotamine.

Children: The safety and effectiveness of Dihydroergotamine for children less than 16 years of age have not been established. It is not recommended for use by children.

Dihydroergotamine frequently asked questions

How To Buy Dihydroergotamine Online?

You can buy Dihydroergotamine online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Dihydroergotamine?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Dihydroergotamine in Canada?

Shipping cost for Dihydroergotamine to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Dihydroergotamine delivered to my home?

You could get Dihydroergotamine delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Dihydroergotamine in Canada for free?

You can get Dihydroergotamine for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Dihydroergotamine for free.

Can I consult a doctor online to get Dihydroergotamine?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Dihydroergotamine.

Can I buy Dihydroergotamine without a prescription?

You need a valid prescription to buy Dihydroergotamine from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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