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Dihydroergotamine belongs to a family of medications called ergot alkaloids. It is used to help relieve the pain of migraine Headaches.

Available form


Nasal Spray


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Migranal information

Side Effects
Available Form

The recommended dose of dihydroergotamine is one spray in each nostril (total of 2 sprays) at the first sign or symptom of a migraine headache, or as early as possible after the onset of migraine headache pain. If the migraine has not improved sufficiently after about 15 minutes, one additional spray can be used in each nostril (total of 2 more sprays).

One bottle of dihydroergotamine nasal spray contains 4 sprays. No more than 4 sprays (2 in each nostril, i.e., one bottle) should be used for any migraine attack. No more than 8 sprays (2 bottles) should be used in any 24-hour period. No more then 24 sprays (6 bottles) should be used in any 7-day period.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Migranal (Dihydroergotamine-nasal) exactly as prescribed by your doctor.

The spray should be used in the following manner (see package insert for illustrated details):

  • Start to prepare the sprayer only when you have a migraine attack.
  • Slowly lift and bend back the lip of the blue seal to show the rubber stopper. Try not to break the blue seal.
  • Completely remove the seal and metal collar in one piece, if possible. If the two should break apart, carefully continue removing the metal collar. The collar has a sharp edge - handle it with care.
  • Gently pull the rubber stopper out of the bottle. Be careful not to spill the contents.
  • Gently remove the transparent plastic protective cover from the bottom of the sprayer. Insert the sprayer into the bottle and tighten firmly onto the bottle in a clockwise direction.
  • Holding the bottle upright, gently remove the blue plastic protective cap from the top of the sprayer.
  • Prior to use, the sprayer must be primed (pumped 4 times in the air).
  • Hold your head straight.
  • Insert the sprayer into one nostril and pump the sprayer once to release the medication. Repeat in the other nostril (a total of 2 sprays).
  • Don't blow your nose.
  • Wait about 15 minutes. If you have not already experienced sufficient relief, or to obtain optimal efficacy and long-lasting relief, repeat the spray once in each nostril. Discard the bottle and sprayer after use or within 8 hours of preparation.
  • Lie down in a quiet, dark room for a while after you use Migranal (Dihydroergotamine-nasal). This may help with your treatment.

Store the product at room temperature.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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Yes, you need a valid prescription, or Rx for short, from a Canadian prescriber to purchase medication that requires a prescription. If you need a new prescription, please contact us and we can help connect you with a doctor or we will reach out to your doctor for a renewal.

How can I refill my medication?

We will gladly coordinate with your doctor and insurance company to make sure you never run out of the medication you need. Additionally, we will remind you when it's time to schedule a delivery for your refill. You can also opt into automatic refills online, in the app, or by calling us at 1-855-950-7225.

Is Pocketpills free? How much does it cost?

Yes, Pocketpills services are free! You only pay your portion of your copay, and there are no hidden delivery or service fees. We'll transfer your prescriptions from your old pharmacy, find savings, and hand-deliver your medications at no extra cost.

What insurance plans do you accept?

We accept all insurance plans and direct bill ODB, OHIP+, and PharmaCare.

How much is shipping cost For Migranal in Canada?

Shipping cost for Migranal to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Migranal delivered to my home?

You could get Migranal delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.
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