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Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called "triptans"). It is used to treat migraine Headaches with or without aura (warning signs that occur prior to the onset of a migraine).
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Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called "triptans"). It is used to treat migraine Headaches with or without aura (warning signs that occur prior to the onset of a migraine). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Sumatriptan relieves migraine headaches by constricting these blood vessels.
Sumatriptan is not recommended for other types of headache or for headache prevention.
In most people, sumatriptan eliminates or reduces the symptoms of migraine, including headache, nausea, vomiting, and sensitivity to light and sound. Significant relief of migraine pain is usually experienced by about 10 to 15 minutes after using the injection, 15 minutes after using the nasal spray, and about 30 minutes after taking the oral tablets.
Ratio Sumatriptan may be available under multiple brand names and/or in several different forms. Any specific brand name of Ratio Sumatriptan may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Ratio Sumatriptan may not be used for all of the conditions discussed here.
Your doctor may have suggested Ratio Sumatriptan for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Ratio Sumatriptan, speak to your doctor. Do not stop using Ratio Sumatriptan without consulting your doctor.
Do not give Ratio Sumatriptan to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Ratio Sumatriptan if their doctor has not prescribed it.
The recommended adult dose of the tablets ranges from 25 mg to 100 mg. The most common dose is 50 mg.
If the headache returns, or if there is partial but not total relief, the dose may be repeated after 2 hours. If a dose has not helped your headache at all, do not take a second dose without first consulting a doctor. Not more than 200 mg should be taken during any 24-hour period.
The tablet should be swallowed whole with water, and not crushed, chewed, or split.
It is important to take Ratio Sumatriptan exactly as prescribed by your doctor.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Store Ratio Sumatriptan at room temperature, protect it from moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Ratio Sumatriptan. If you are concerned about side effects, discuss the risks and benefits of Ratio Sumatriptan with your doctor.
The following side effects have been reported by at least 1% of people taking Ratio Sumatriptan. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ratio Sumatriptan.
Ratio-Sumatriptan is no longer being manufactured for sale in Canada. For brands that may still be available, search under sumatriptan. This article is being kept available for reference purposes only. If you are using Ratio Sumatriptan, speak with your doctor or pharmacist for information about your treatment options.
Do not use sumatriptan if you:
There may be an interaction between sumatriptan and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Ratio Sumatriptan. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ratio Sumatriptan.
Allergy: If you are allergic to sulphonamides (sulfa medications) you may experience an allergic reaction to sumatriptan. Reactions range from a skin allergy to a serious allergic reaction. If you are allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) you can also have an allergic reaction to sumatriptan. If you are allergic to any of these medications, you should not take sumatriptan unless advised to do so by your doctor.
Blood pressure: Sumatriptan may cause an increase in blood pressure. If you have severe or uncontrolled high blood pressure, do not take sumatriptan.
Drowsiness/reduced alertness: Drowsiness may occur as a result of taking Ratio Sumatriptan. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how Ratio Sumatriptan affects you.
Heart disease: Ratio Sumatriptan may cause narrowing of the blood vessels that supply the heart. This can lead to chest pain, heart attacks, and other heart problems. For this reason, sumatriptan should not be used by people with heart or blood vessel disease. If you have certain risk factors for heart disease (e.g., high blood pressure, High Cholesterol, smoking, Obesity, Diabetes, family history of Coronary Artery Disease, Menopause, men over 40 years of age), tell your doctor. If you experience symptoms of a heart attack (e.g., pain, pressure, tightness, or heaviness in the chest, jaw, neck, or shoulder; sweating; or shortness of breath), get immediate medical attention.
Injection: The injectable form of sumatriptan should never be taken intravenously (into a vein).
Kidney function: The effect of reduced kidney function on how sumatriptan acts in the body has not been evaluated. Sumatriptan is not recommended for use if you have reduced kidney function.
Liver function: Liver disease or reduced liver function may cause Ratio Sumatriptan to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Ratio Sumatriptan may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ratio Sumatriptan, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Ratio Sumatriptan.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
A lower dose of sumatriptan may be needed for people with reduced liver function. However, sumatriptan is not recommended for use if you have severely reduced liver function.
Medication overuse headaches: As with other pain relief medications, overuse of sumatriptan may lead to medication overuse headaches, or "rebound headaches" where the headache returns as the medication wears off. Avoid taking more of Ratio Sumatriptan than is recommended by your doctor. If you experience more frequent headaches, contact your doctor as soon as possible.
Seizures: There have been rare reports of seizures experienced by people taking Ratio Sumatriptan. Most of these people had a previous history of Epilepsy or medical conditions that increase the risk of seizures. If you have a history of epilepsy or other condition that increases your risk for seizure, discuss with your doctor how Ratio Sumatriptan may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ratio Sumatriptan, and whether any special monitoring is needed.
Serotonin syndrome: People who use sumatriptan along with serotonin reuptake inhibitors (SSRIs; e.g., Paroxetine, Citalopram, Fluoxetine), serotonin norepinephrine reuptake inhibitors (SNRIs; e.g., Venlafaxine), or other medications that act on serotonin, may experience serotonin syndrome. This syndrome is severe and can be life-threatening. If you are taking antidepressants, discuss with your doctor how Ratio Sumatriptan may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ratio Sumatriptan, and whether any special monitoring is needed.
If you experience symptoms of serotonin syndrome (e.g., agitation, hallucinations, fast heartbeat, Fever, increased reflexes, nausea, vomiting, Diarrhea) after using sumatriptan, get immediate medical attention.
Stroke and bleeding around the brain: Rarely, Ratio Sumatriptan may cause cerebrovascular events such as stroke and bleeding around the brain. If you have had a previous stroke or are at risk for it, talk to your doctor about the use of Ratio Sumatriptan. If you experience signs and symptoms of a stroke (e.g., sudden numbness or weakness, especially on one side of the body; sudden confusion or problems with speech; sudden vision problems in one or both eyes; sudden dizziness or loss of coordination; sudden severe headache, especially if it seems different from your usual headaches), get immediate medical attention.
Pregnancy: Ratio Sumatriptan should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Ratio Sumatriptan, contact your doctor immediately.
Breast-feeding: Ratio Sumatriptan passes into breast milk. If you are a breast-feeding mother and are taking sumatriptan, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children and adolescents: The safety and effectiveness of Ratio Sumatriptan have not been established for adolescents and children under 18 years of age.
Seniors: There is limited experience with the use of sumatriptan by people over 65 years of age. The use of Ratio Sumatriptan by seniors is not recommended.
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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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