Piroxicam
Piroxicam belongs to the group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to relieve the symptoms of Rheumatoid Arthritis, osteoarthritis, and ankylosing spondylitis (a condition associated with inflammation of the joints in the spine and between the spine and pelvis).
Available form
Capsule, Suppository
Dosage
10mg, 20mg
Manufacturers
Apotex, Pharmascience, Teva
Branded drugs
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The recommended dose of piroxicam ranges from 10 mg to 20 mg daily, depending on needs and circumstances. A dose of 20 mg can be taken as either 20 mg once daily or 10 mg twice daily. Take Piroxicam immediately after food, or with food or milk to avoid stomach upset. The usual maximum daily dose is 20 mg. Piroxicam suppositories are also an alternative. The lowest dose needed for the shortest possible duration of treatment should be used.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important to use Piroxicam exactly as prescribed by your doctor. If you miss a dose and are taking piroxicam once a day, take it within 8 hours of your usual dose time and continue with your regular schedule. If you have missed your dose by more than 8 hours, skip the missed dose and continue with your regular dosing schedule. If you miss a dose and are taking piroxicam twice a day, take it within 2 hours of your usual dose time and continue with your regular schedule. If you have missed your dose by more than 2 hours, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Piroxicam at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Piroxicam. If you are concerned about side effects, discuss the risks and benefits of Piroxicam with your doctor.
The following side effects have been reported by at least 1% of people taking Piroxicam. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
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Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Piroxicam.
Capsule
10 mg
Each hard gelatin capsule with deep powder blue opaque body, imprinted with "PIROXICAM 10" and maroon opaque cap imprinted with the Pharmascience "P" logo, contains piroxicam 10 mg. Nonmedicinal ingredients: corn starch, D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, lactose, magnesium stearate, sodium lauryl sulphate, and titanium dioxide.
20 mg
Each hard gelatin capsule with maroon opaque body, imprinted with "PIROXICAM 20" and maroon opaque cap imprinted with the Pharmascience "P" logo, contains piroxicam 20 mg. Nonmedicinal ingredients: corn starch, D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, lactose, magnesium stearate, sodium lauryl sulphate, and titanium dioxide.
Suppository
10 mg
Each white-to-off-white cone-shaped suppository contains piroxicam 20 mg. Nonmedicinal ingredients: microcrystalline wax, propyl gallate, and suppocire.
20 mg
Each white-to-off-white cone-shaped suppository contains piroxicam 20 mg. Nonmedicinal ingredients: microcrystalline wax, propyl gallate, and suppocire.
Do not use Piroxicam if you:
Do not give Piroxicam to children and adolescents under 16 years of age, or let them use it.
Do not use the suppository form of Piroxicam if you have inflammation or recent bleeding from the anus or rectum.
There may be an interaction between piroxicam and any of the following:
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If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Piroxicam. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Piroxicam.
Health Canada has issued new information concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
A previous advisory on non-steroidal anti-inflammatory drugs (NSAIDs) was issued on October 30, 2020.
Allergic reactions: If you have had a reaction to acetylsalicylic acid (ASA) or other NSAIDs (e.g., ibuprofen, Ketoprofen, ketorolac) that included a runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing, you should not take Piroxicam. If you experience symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; wheezing; swelling of the face, tongue, or throat), get immediate medical attention.
Aseptic meningitis: Piroxicam can rarely cause symptoms of aseptic meningitis (inflammation or swelling of the membranes around the brain and spinal cord that is not caused by bacteria). If you have an autoimmune condition (e.g., systemic Lupus erythematosus, mixed connective tissue disease), you are more at risk for developing this. If you experience symptoms such as stiff neck, severe headache, nausea, vomiting, fever, or changes in consciousness, stop taking Piroxicam can get immediate medical attention.
Bladder problems: Piroxicam may cause bladder pain, painful or difficult urination, or increased frequency of urination. If these symptoms occur without an explanation (e.g., infection), stop taking Piroxicam and contact your doctor.
Blood clotting: Piroxicam may reduce the ability of the blood to clot. If you are taking anticoagulants (e.g., Warfarin, Heparin) or have Hemophilia or other blood disorders (e.g., low platelets), discuss with your doctor how Piroxicam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Piroxicam, and whether any special monitoring is needed. If you have a bleeding disorder, do not take Piroxicam.
Blood counts: This medication can decrease the number of neutrophils (a type of white blood cell that helps fight infection), red blood cells (which carry oxygen), and platelets (which help your blood to clot). Your doctor will do blood tests to monitor this. If you notice any signs of Anemia (e.g., unusual tiredness, difficulty breathing) or unusual bleeding or bruising, contact your doctor.
Drowsiness/reduced alertness: Piroxicam may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how Piroxicam affects you.
Fluid and electrolyte balance: NSAIDs such as piroxicam can cause fluid retention and edema (swelling). This can lead to high blood pressure or worsening of heart failure. If you have heart failure or high blood pressure, discuss with your doctor how Piroxicam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Piroxicam, and whether any special monitoring is needed. If you have severe, uncontrolled heart failure, you should not take Piroxicam.
Piroxicam may also cause high blood potassium levels. If you are a senior; have Diabetes or kidney failure; or are taking beta-blockers (e.g., Metoprolol, Atenolol), angiotensin converting enzyme (ACE) inhibitors (e.g., Ramipril, Enalapril), or some diuretics (e.g., triamterene, Amiloride), you are more at risk of high blood potassium. If you have high blood potassium levels, you should not take Piroxicam.
Heart attack and stroke: Piroxicam may be associated with an increased risk of heart attack or stroke. The risk is higher with larger total daily doses and longer treatment periods. If you have a history of heart disease (e.g., heart attack, stroke, heart failure) or have risk factors for heart disease (e.g., high blood pressure, High Cholesterol, diabetes, smoking, Kidney Disease) discuss with your doctor how Piroxicam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Piroxicam, and whether any special monitoring is needed.
Kidney function: Long-term use of piroxicam may lead to a higher risk of reduced kidney function. If you have kidney disease, liver disease, or heart failure; take diuretics (water pills); or are a senior: you have an increased risk for kidney problems while taking Piroxicam. .If you are taking medications such as diuretics (e.g., Hydrochlorothiazide, triamterene, Indapamide), ACE inhibitors (e.g., enalapril, ramipril), angiotensin receptor blockers (e.g., Valsartan, Candesartan), or Cyclosporine, you are also at an increased risk.
If you have these conditions or are taking these medications, discuss with your doctor how Piroxicam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Piroxicam, and whether any special monitoring is needed. If you have severe kidney problems, you should not take Piroxicam.
Liver function: Liver disease or reduced liver function may cause Piroxicam to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Piroxicam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Piroxicam, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Piroxicam.
Rarely, Piroxicam causes liver problems. If you experience unexplained tiredness, loss of appetite, itchy skin or yellowing of the skin or eyes while taking Piroxicam, contact your doctor immediately. If you have liver disease or severely reduced liver function, you should not take Piroxicam.
Skin reactions: This medication can cause skin reactions, some of which may be severe. If you experience a skin rash, especially where the skin is blistering or peeling, stop taking Piroxicam and contact your doctor.
Piroxicam may make your skin more sensitive to sunlight (including sunlamps) and may cause Sunburn, skin blisters, and skin redness, itching or discolouration. If you have a reaction from the sun while taking Piroxicam, contact your doctor.
Ulcers or bleeding in the stomach or intestines: Piroxicam can cause stomach ulcers, perforation (holes), and bleeding from the stomach. These complications can occur at any time without warning, and are sometimes severe enough to require immediate medical attention. The risk of ulcers and bleeding increase if you are taking higher doses of piroxicam for longer periods of time.
Other factors that increase the risk of these complications include drinking excessive amounts of alcohol, increased age, smoking, poor health, H pylori infection, and taking certain medications (e.g., warfarin, ASA, Clopidogrel, Prednisone, Citalopram, Fluoxetine, Paroxetine, Sertraline).
If you currently have ulcers in the stomach or intestines that are bleeding, or have an inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), you should not take Piroxicam. If you have a history of these conditions, discuss with your doctor how Piroxicam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Piroxicam, and whether any special monitoring is needed.
Stop taking the medication and get immediate medical attention if you experience symptoms or signs of stomach ulcers or bleeding in the stomach (black, tarry stools, blood in stools, stomach pain, vomiting blood or coffee-grind material). These reactions can occur at any time during treatment without warning.
Pregnancy: Piroxicam should not be used during pregnancy, especially during the third trimester. If you become pregnant while taking Piroxicam, contact your doctor immediately.
Piroxicam may reduce fertility. If you are trying to get pregnant or are having difficulty getting pregnant, you should not use Piroxicam.
Breast-feeding: Piroxicam passes into breast milk. If you are a breast-feeding mother and are taking Piroxicam, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of Piroxicam have not been established for children less than 16 years of age.
Seniors: If you are a senior, you may have a higher risk of experiencing side effects from Piroxicam. You should use the lowest effective dose under close medical supervision.
Piroxicam belongs to the group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to relieve the symptoms of Rheumatoid Arthritis, osteoarthritis, and ankylosing spondylitis (a condition associated with inflammation of the joints in the spine and between the spine and pelvis).
Piroxicam relieves pain and reduces swelling and inflammation by reducing a substance in the body that leads to inflammation and pain. Piroxicam will not cure your condition or prevent it from getting worse.
Piroxicam may be available under multiple brand names and/or in several different forms. Any specific brand name of Piroxicam may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Piroxicam may not be used for all of the conditions discussed here.
Your doctor may have suggested Piroxicam for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are using Piroxicam, speak to your doctor. Do not stop using Piroxicam without consulting your doctor.
Do not give Piroxicam to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Piroxicam if their doctor has not prescribed it.
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