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Pramipexole belongs to the class of medications called dopamine agonists. It is used to treat signs and symptoms of Parkinson's Disease.
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Pramipexole belongs to the class of medications called dopamine agonists. It is used to treat signs and symptoms of Parkinson's Disease. It is also used to treat symptoms of moderate to severe Restless Leg Syndrome. It helps to improve muscle control and movement by affecting the balance of a chemical in the brain called dopamine.
Apo Pramipexole may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Pramipexole may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Pramipexole may not be used for all of the conditions discussed here.
Your doctor may have suggested Apo Pramipexole for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Apo Pramipexole, speak to your doctor. Do not stop taking Apo Pramipexole without consulting your doctor.
Do not give Apo Pramipexole to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Apo Pramipexole if their doctor has not prescribed it.
For Parkinson's disease, the recommended adult dose starts at 0.375 mg daily, taken in 3 divided doses. Depending on the response to the medication as well as side effects, the dose may be increased every 5 to 7 days to obtain the desired effects. The maximum recommended dose should not exceed 4.5 mg daily, taken in 3 divided doses.
For restless leg syndrome, the recommended adult dose starts at 0.125 mg once daily, taken 2 to 3 hours before bedtime. The dose may be increased every 4 to 7 days to a maximum of 0.5 mg 2 to 3 hours before bedtime. Pramipexole may be taken with or without food. You should take it with food if you find that you feel sick to your stomach after taking the tablets.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Apo Pramipexole exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Apo Pramipexole at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Apo Pramipexole. If you are concerned about side effects, discuss the risks and benefits of Apo Pramipexole with your doctor.
The following side effects have been reported by at least 1% of people taking Apo Pramipexole. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Pramipexole.
Each white-to-off-white, round, flat-faced, bevelled-edged tablet, engraved "APO" on one side and "PR" over ".125" on the other, contains 0.125 mg of pramipexole dihydrochloride monohydrate. Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and starch (corn).
Each white-to-off-white, oval, flat-faced, bevelled-edged tablet, engraved "PR" scoreline ".25" on one side and "APO" on the other, contains 0.25 mg of pramipexole dihydrochloride monohydrate. Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and starch (corn).
Each white-to-off-white, oval, flat-faced, bevelled-edged tablet, engraved "PR" scoreline ".5" on one side and "APO" on the other, contains 0.5 mg of pramipexole dihydrochloride monohydrate. Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and starch (corn).
Each white-to-off-white, oval, flat-faced, bevelled-edged tablet, engraved "APO" on one side and "PR.75" on the other, contains 0.75 mg of pramipexole dihydrochloride monohydrate Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and starch (corn).
Each white-to-off-white, round, flat-faced, bevelled-edged tablet, engraved "PR" over score "1" on one side and "APO" on the other, contains 1 mg of pramipexole dihydrochloride monohydrate. Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and starch (corn).
Each white-to-off-white, round, flat-faced, bevelled-edged tablet, engraved "PR" over score "1.5" on one side and "APO" on the other, contains 1.5 mg of pramipexole dihydrochloride monohydrate. Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and starch (corn).
Pramipexole should not be taken by anyone who is allergic to pramipexole or to any of the ingredients of the medication.
There may be an interaction between pramipexole and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Apo Pramipexole. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription) and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or illegal drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Apo Pramipexole.
Behaviour changes: People taking pramipexole have experienced abnormal behaviour such as compulsive gambling, compulsive shopping, hypersexuality, and binge eating. If you experience these symptoms or any other behaviour change while taking Apo Pramipexole, contact your doctor immediately.
Blood pressure: Pramipexole can lower blood pressure for some people. People taking Apo Pramipexole may feel dizzy or lightheaded when rising from a sitting or lying position. Make sure to tell your doctor if you experience this effect. If you have severe heart disease, discuss with your doctor how Apo Pramipexole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Pramipexole, and whether any special monitoring is needed.
Drowsiness/sudden onset of sleep: Pramipexole and similar mediations can cause drowsiness and sudden onset of sleep or sleep attacks. Sudden onset of sleep can occur without warning or drowsiness. People taking Apo Pramipexole should avoid driving or operating heavy machinery. If you experience any daytime drowsiness or sudden onset of sleep while taking Apo Pramipexole, contact your doctor immediately.
Hallucinations: People taking Apo Pramipexole should be aware that hallucinations (mainly seeing things that are not really there) can occur and may affect their ability to drive and perform other daily activities. Make sure to tell your doctor if you experience this effect.
Kidney function: Decreased kidney function or Kidney Disease can cause Apo Pramipexole to build up in the body, causing side effects. People with reduced kidney function should discuss with their doctor how Apo Pramipexole may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Apo Pramipexole, and whether any special monitoring is needed. Pramipexole is not recommended for people with end-stage renal disease.
Melanoma: People with Parkinson's disease may be at increased risk of developing melanoma (a type of Skin Cancer). It is not known if this increased risk is due to Parkinson's disease or to the medications used to treat Parkinson's disease. Your doctor will monitor you for skin cancer while you are taking Apo Pramipexole. Talk to your doctor if you have any concerns.
Neuroleptic malignant syndrome (NMS): As with other medications that have an effect on movement disorders, pramipexole can trigger a potentially fatal set of symptoms known as neuroleptic malignant syndrome (NMS). If you experience symptoms of NMS, such as high Fever; muscle stiffness; confusion or loss of consciousness; sweating; or rapid or irregular heartbeat, seek immediate medical attention.
This is more likely to occur if pramipexole is stopped suddenly or the dose is decreased rapidly. If you are considering stopping Apo Pramipexole, talk with your doctor about the appropriate way to reduce pramipexole.
Restless leg syndrome: When Apo Pramipexole is used to treat the symptoms of restless leg syndrome, it may cause a worsening of symptoms in the early morning hours. It may also cause earlier onset of symptoms in the evening or an increase in symptoms. If you experience this, let your doctor know.
Stopping treatment: Do not stop taking Apo Pramipexole without consulting with your doctor. Stopping this mediation suddenly can cause symptoms such as fever, rigid muscles, and blood pressure changes. If you and your doctor decide that stopping Apo Pramipexole is best for you, your doctor will gradually reduce your dose over a week.
Suicidal or agitated behaviour: People with Parkinson's disease are at risk of experiencing thoughts and intent of self-harm or suicide. These feelings may not pass when the symptoms of PD are relieved. If you have Depression or bipolar disorder, you may be at an increased risk of feeling agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or wanting to hurt themselves or others. If you experience these side effects or notice them in a family member who is taking Apo Pramipexole, contact your doctor immediately.
Pregnancy: Apo Pramipexole should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Apo Pramipexole, contact your doctor immediately.
Breast-feeding: It is not known if pramipexole passes into breast milk. Since the medication reduces the amount of breast milk produced, women who are breast-feeding should not take Apo Pramipexole.
Children: The safety and effectiveness of using pramipexole has not been established for children.
Seniors: Seniors may be more likely to experience hallucinations (hearing, seeing or feeling things that are not there) while taking pramipexole.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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