Pravachol (Pravastatin) belongs to the family of medications known as HMG CoA reductase inhibitors ("statins"). It is used in addition to diet and exercise to lower High Cholesterol levels. Pravachol (Pravastatin) works by blocking an enzyme that is needed to make cholesterol in the liver. Therefore, less cholesterol is made and levels of cholesterol in the blood decrease. Lowering cholesterol levels in the blood has been shown to reduce the risks associated with heart disease, such as Heart Attack.

Pravachol (Pravastatin) can be used to reduce the risk of death, heart attacks, Stroke, angioplasty, and hospitalization for people with heart disease and normal to moderately high cholesterol. It is also used to reduce the risk of heart attacks, angioplasty, and death for people with high cholesterol who do not already have heart disease.

The medication usually takes about 4 weeks to have a significant effect on cholesterol levels in your blood. After this time, your doctor will likely send you for a lab test to check for changes in your cholesterol levels.

Pravachol (Pravastatin) may be available under multiple brand names and/or in several different forms. Any specific brand name of Pravachol (Pravastatin) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Pravachol (Pravastatin) may not be used for all of the conditions discussed here.

Your doctor may have suggested Pravachol (Pravastatin) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Pravachol (Pravastatin), speak to your doctor. Do not stop taking Pravachol (Pravastatin) without consulting your doctor.

Do not give Pravachol (Pravastatin) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Pravachol (Pravastatin) if their doctor has not prescribed it.

Before starting Pravachol (Pravastatin), you should be on a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should be implemented.

The recommended starting dose of Pravachol (Pravastatin) is 20 mg daily, taken with or without food in a single dose at bedtime. Your doctor will do blood tests to tell how well this dose is working for you and may gradually increase the dose to get the desired response. The maximum recommended dose for adults is 80 mg taken once daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

For best results in lowering your cholesterol, it is very important that you closely follow the diet suggested by your doctor. It is also very important that you take Pravachol (Pravastatin) exactly as prescribed by your doctor.

If you miss a dose of Pravachol (Pravastatin), take it as soon as you remember and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Pravachol (Pravastatin) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Pravachol (Pravastatin). If you are concerned about side effects, discuss the risks and benefits of Pravachol (Pravastatin) with your doctor.

The following side effects have been reported by at least 1% of people taking Pravachol (Pravastatin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Constipation
• cough
• Diarrhea
• dizziness
• headache
• heartburn
• nausea
• nightmares
• rash
• sexual problems
• trouble sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• anxiety or nervousness
• chest pain
• confusion
• cough or shortness of breath
• memory loss or forgetfulness
• signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
• symptoms of liver problems (e.g., yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)
• symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a Fever or a general feeling of being unwell)
• vision problems (i.e., blurred vision)

Stop taking the medication and seek medical attention immediately if any of the following occur:

• severe skin rash, including skin blistering and peeling (possibly with headache, fever, sore throat or mouth, coughing, or aching)
• symptoms of a serious allergic reaction (such as swelling of the face or throat, Hives, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Pravachol (Pravastatin).

20 mg
Each yellow, rounded, rectangular-shaped, biconvex tablet, with a "P" embossed on one side and "PRAVACHOL 20" engraved on the other, contains 20 mg of Pravachol (Pravastatin) sodium. Nonmedicinal ingredients: croscarmellose sodium, D&C Yellow No. 10 (40 mg tablets), FD&C Blue No. 1 (40 mg tablets), lactose, magnesium oxide, magnesium stearate, microcrystalline cellulose, povidone, and yellow ferric oxide (20 mg tablets).

40 mg
Each green, rounded, rectangular-shaped, biconvex tablet, with a "P" embossed on one side and "PRAVACHOL 40" engraved on the other, contains 40 mg of Pravachol (Pravastatin) sodium. Nonmedicinal ingredients: croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 1, lactose, magnesium oxide, magnesium stearate, microcrystalline cellulose, and povidone.

Do not take Pravachol (Pravastatin) if you:

• are allergic to Pravachol (Pravastatin) or any ingredients of Pravachol (Pravastatin)
• are breast-feeding
• are pregnant or plan to become pregnant
• have active liver disease or unexplained increases in liver function tests

There may be an interaction between Pravachol (Pravastatin) and any of the following:

• "azole" antifungal medications (e.g., ketoconazole, itraconazole)
• Carbamazepine
• certain HIV protease inhibitors (e.g., darunavir, letermovir, nelfinavir, saquinavir)
• Cholestyramine
• Colchicine
• Colesevelam
• Colestipol
• Cyclosporine
• daptomycin
• efavirenz
• Eltrombopag
• fibrates (e.g., Bezafibrate, gemfibrozil, fenofibrate)
• Hepatitis C antiviral medications (e.g., asunaprevir, daclatasvir, glecavir, ledipasvir, pibrentasvir, sofosbuvir, voxilaprevir)
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• niacin (nicotinic acid)
• niacinamide
• Paroxetine
• Phenytoin
• raltegravir
• Repaglinide
• rifabutin
• rifampin
• rupatadine
• Teriflunomide
• Tolvaptan
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Pravachol (Pravastatin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.