Suprefact Depot

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Available Form:  

INJ.IMPLANT

Manufacturer name:  

Cheplapharm Arzneimittel Gmbh

Generic name:  

BUSERELIN

Strength:  

6.3MG

What is Suprefact Depot?

Suprefact Depot (Buserelin) is a medication that has been designed to mimic the actions of natural gonadotropin releasing hormone (GnRH or LHRH), a hormone released from the hypothalamus gland in the brain. The hypothalamus uses GnRH to send messages to the pituitary gland in the brain, which then sends messages to the ovaries in females, and the testicles in males, telling them to produce the sex hormones estrogen (females) and testosterone (males).

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How much does Suprefact Depot cost?

  • The cost of Suprefact Depot is $0 with us here at PocketPills. The cost of Suprefact Depot can be lower if your insurance covers it. To calculate the total price of purchasing Suprefact Depot, you should also consider dispensing and delivery fees.

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Suprefact Depot 

Indication

Suprefact Depot (Buserelin) is a medication that has been designed to mimic the actions of natural gonadotropin releasing hormone (GnRH or LHRH), a hormone released from the hypothalamus gland in the brain.

The hypothalamus uses GnRH to send messages to the pituitary gland in the brain, which then sends messages to the ovaries in females, and the testicles in males, telling them to produce the sex hormones estrogen (females) and testosterone (males).

Normally, GnRH comes from the hypothalamus in pulses. If GnRH came from the hypothalamus all of the time (rather than in "pulses"), it would have the opposite effect and "turn off" hormone production. Suprefact Depot (Buserelin) works by acting in place of GnRH and causes hormone production to be "turned off." As a result, the production of estrogen and testosterone by the body is reduced.

Suprefact Depot (Buserelin) is used for the treatment of advanced Prostate Cancer. It helps prostate cancer by causing a reduction in the amount of testosterone in the blood. It is also used to treat Endometriosis (a painful condition caused by growth of extra tissue inside or outside the uterus). It helps endometriosis by reducing the amount of estrogen in the blood.

Suprefact Depot (Buserelin) may be available under multiple brand names and/or in several different forms. Any specific brand name of Suprefact Depot (Buserelin) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Suprefact Depot (Buserelin) may not be used for all of the conditions discussed here.

Your doctor may have suggested Suprefact Depot (Buserelin) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are using Suprefact Depot (Buserelin), speak to your doctor. Do not stop using Suprefact Depot (Buserelin) without consulting your doctor.

Do not give Suprefact Depot (Buserelin) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Suprefact Depot (Buserelin) if their doctor has not prescribed it.

Suprefact Depot 

Dosage

Suprefact Depot (Buserelin) is available in injectable forms and nasal solution.

For prostate cancer, the usual starting dose is Suprefact Depot (Buserelin) 500 µg by subcutaneous (under the skin) injection every 8 hours for 7 days. This is followed by maintenance therapy with an injection of 200 µg Suprefact Depot (Buserelin) once daily or 400 µg of nasal spray (2 sprays into each nostril) 3 times daily.

Women using Suprefact Depot (Buserelin) for treatment of endometriosis usually use the Suprefact Depot (Buserelin) nasal solution at a dose of 400 µg (2 sprays into each nostril) 3 times daily. The treatment usually continues for 6 months but should not continue past 9 months.

If using the injectable form, always use the syringes provided in the kit and dispose of the syringes in a safe manner. Carefully read the patient directions for use available in the package insert. Ask your health care professional if you have any questions. To help reduce redness, itching, or swelling where the medication is injected, rotate the place where you are injecting Suprefact Depot (Buserelin).

If using the nasal spray, use the spray pump provided. Each spray delivers 100 µg Suprefact Depot (Buserelin). Carefully read the patient directions for use available in the package insert. Ask your health professional if you have any questions.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Suprefact Depot (Buserelin) exactly as prescribed by your doctor. If you miss a dose, use it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

For men using Suprefact Depot (Buserelin) for long-term control of prostate cancer, a long-lasting Suprefact Depot (Buserelin) implant (called a "depot") can be implanted under the skin into the abdominal wall by the doctor every 2 or 3 months. If you forget to have your implant given on the correct day, have it administered as soon as possible.

Store Suprefact Depot (Buserelin) at room temperature, away from heat and direct light, and keep it out of the reach of children. The injection can be kept at room temperature for up to 14 days after opening. The nasal spray can be kept at room temperature for up to 5 weeks after opening.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Suprefact Depot 

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses Suprefact Depot (Buserelin). If you are concerned about side effects, discuss the risks and benefits of Suprefact Depot (Buserelin) with your doctor.

The following side effects have been reported by at least 1% of people using Suprefact Depot (Buserelin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • Acne
  • breast pain
  • burning, itching, redness, or swelling at injection site
  • decrease in sexual desire
  • dizziness
  • Headaches
  • impotence
  • nausea
  • nose irritation or dryness (with nasal solution)
  • sudden sweating and feeling of warmth (hot flashes)
  • trouble sleeping
  • vaginal dryness
  • weakness
  • weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bone or joint pain
  • initial worsening of symptoms or new symptoms such as pain or difficulty urinating
  • signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • swelling of the feet or lower legs
  • symptoms of irregular heart beat (e.g., chest pain, dizziness, rapid, pounding heartbeat, shortness of breath)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a Anaphylaxis (severe allergic reaction) (e.g., Hives; difficulty breathing; difficulty swallowing; or swelling of the face, mouth, tongue, or throat)
  • symptoms of severely increased blood pressure: (e.g., chest pain, blurred vision, dizziness, excessive tiredness, headache, stronger or faster heart beat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Suprefact Depot (Buserelin).

Suprefact Depot 

Available form

Depot 2 Months
Each applicator contains 1 implant dose consisting of 2 identical cream-coloured, biodegradable, and biocompatible rods. Each implant dose contains a total of 6.6 mg of Suprefact Depot (Buserelin) acetate, equivalent to 6.3 mg of Suprefact Depot (Buserelin) base. Nonmedicinal ingredients: poly-(D,L-lactide-co-glycolide). Sterile ready-to-use disposable applicator with an integrated needle (internal needle diameter of 1.4 mm) for s.c. injection.

Depot 3 Months
Each applicator contains 1 implant dose consisting of 3 identical cream-coloured, biodegradable, and biocompatible rods. Each implant dose contains a total of 9.9 mg of Suprefact Depot (Buserelin) acetate equivalent to 9.45 mg of Suprefact Depot (Buserelin) base. Nonmedicinal ingredients: poly-(D,L-lactide-co-glycolide). Sterile ready-to-use disposable applicator with an integrated needle (internal needle diameter of 1.4 mm) for s.c. injection.

Suprefact Depot 

Contraindications

Do not use Suprefact Depot (Buserelin) if you:

  • are allergic to Suprefact Depot (Buserelin) or any ingredients of Suprefact Depot (Buserelin)
  • are a man with non-hormone dependent cancer
  • are pregnant or breast-feeding
  • have prostate cancer and have had your testicles removed
  • have undiagnosed abnormal vaginal bleeding

Suprefact Depot 

Precautions

There may be an interaction between Suprefact Depot (Buserelin) and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Suprefact Depot (Buserelin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Suprefact Depot 

Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Suprefact Depot (Buserelin).

Anemia: Reduced testosterone levels contribute to low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, pale skin, or feeling unusually tired, contact your doctor as soon as possible.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.

Blood pressure: If you have high blood pressure, Suprefact Depot (Buserelin) may increase your blood pressure. Your blood pressure should be checked regularly while using Suprefact Depot (Buserelin).

Depression: Changed levels of hormones in the body have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, or decreased interest in activities, or notice them in a family member who is taking Suprefact Depot (Buserelin), contact your doctor as soon as possible.

Diabetes: Suprefact Depot (Buserelin) may cause a loss of blood glucose control, and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Suprefact Depot (Buserelin).

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

Disease symptoms: Sometimes when Suprefact Depot (Buserelin) is started, you may experience a temporary worsening of your symptoms that will last usually less than 10 days. If you have prostate cancer, you may also experience new symptoms such as bone pain, tingling or numbness, or blood in the urine, and your doctor may prescribe a medication to help prevent this. If you experience worsening of your symptoms or any new symptoms, contact your doctor.

Dizziness: Suprefact Depot (Buserelin) can cause dizziness. Do not drive or operate machinery until you know Suprefact Depot (Buserelin) does not affect your ability to perform these tasks safely.

Heart problems: Suprefact Depot (Buserelin) may increase the risk of heart problems such as changes in heart rhythm. You may be more at risk of experiencing heart problems if you have congenital long QT syndrome, electrolyte (e.g., potassium) abnormalities, or Congestive Heart Failure, or you are taking medications that affect heart rhythm (e.g., quinidine, procainamide, Amiodarone, Sotalol, Flecainide). Discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

Men and the heart: There may be an increased risk of heart-related events (e.g., heart attacks, Stroke, heart-related death) in men being treated for prostate cancer with GnRH medications.

Before you start treatment, tell your doctor if you have diabetes or heart disease, have had a previous Heart Attack or stroke, or have cardiovascular risk factors (e.g., high blood pressure, smoking, or cholesterol). If you have any of these conditions, discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

Osteoporosis: Suprefact Depot (Buserelin) can decrease bone density that can lead to osteoporosis and bone factures. Your doctor will monitor you for this while you are using Suprefact Depot (Buserelin). If you have osteoporosis or are at risk for it (e.g., have been smoking or drinking excessive amounts of alcohol for a long time, have a family history of osteoporosis, or are taking medications such as Prednisone or anti-seizure medications), discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition and whether any special monitoring is needed.

Pregnancy: Suprefact Depot (Buserelin) should not be used by pregnant women. Use an effective nonhormonal method of birth control (e.g., condom, diaphragm, IUD) while you are using Suprefact Depot (Buserelin). If you become pregnant while using Suprefact Depot (Buserelin), stop using the medication and contact your doctor immediately.

Breast-feeding: Suprefact Depot (Buserelin) passes into breast milk. If you are a breast-feeding mother and are taking Suprefact Depot (Buserelin), it may affect your baby. Women should not breast-feed while using Suprefact Depot (Buserelin).

Children: The safety and effectiveness of using Suprefact Depot (Buserelin) have not been established for children and adolescents less than 18 years of age.

Suprefact Depot frequently asked questions

How To Buy Suprefact Depot Online?

You can buy Suprefact Depot online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Suprefact Depot?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Suprefact Depot in Canada?

Shipping cost for Suprefact Depot to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Suprefact Depot delivered to my home?

You could get Suprefact Depot delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Suprefact Depot in Canada for free?

You can get Suprefact Depot for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Suprefact Depot for free.

Can I consult a doctor online to get Suprefact Depot?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Suprefact Depot.

Can I buy Suprefact Depot without a prescription?

You need a valid prescription to buy Suprefact Depot from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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