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Doravirine belongs to a class of medications called antiretroviral agents and more specifically, to the class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcriptase is an enzyme that is needed by human immunodeficiency virus (HIV) for reproduction.
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Doravirine belongs to a class of medications called antiretroviral agents and more specifically, to the class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcriptase is an enzyme that is needed by human immunodeficiency virus (HIV) for reproduction. Doravirine blocks the action of this enzyme.
When used in combination with other antiretroviral medications, doravirine treats HIV infection and helps prevent the HIV from reproducing. HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). HIV infection destroys CD4 (T) cells, which are important to the immune system. The immune system helps fight infections. When used with other antiretroviral medications, doravirine reduces the amount of HIV in the blood and increases CD4 (T) cell counts.
Doravirine must be taken with other medications to treat HIV infection. It is not intended to be taken alone. Pifeltro does not cure AIDS and does not prevent it from being spread to others. It is used to slow further growth or reproduction of HIV and seems to slow down the destruction of the immune system. This may help to delay the development of problems such as infections related to AIDS or HIV.
Pifeltro may be available under multiple brand names and/or in several different forms. Any specific brand name of Pifeltro may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Pifeltro may not be used for all of the conditions discussed here.
Your doctor may have suggested Pifeltro for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Pifeltro, speak to your doctor. Do not stop taking Pifeltro without consulting your doctor.
Do not give Pifeltro to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Pifeltro if their doctor has not prescribed it.
The recommended adult dose of doravirine is 100 mg taken by mouth, once daily. It may be taken with or without food.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Pifeltro exactly as prescribed by your doctor.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Pifeltro in the original bottle at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Pifeltro. If you are concerned about side effects, discuss the risks and benefits of Pifeltro with your doctor.
The following side effects have been reported by at least 1% of people taking Pifeltro. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Pifeltro.
Each white, oval-shaped, film-coated tablet, debossed with the corporate logo and "700" on one side, and plain on the other side, contains 100 mg of doravirine. Nonmedicinal ingredients: carnauba wax, colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, and microcrystalline cellulose; film coating: hypromellose, lactose monohydrate, titanium dioxide, and triacetin.
There may be an interaction between doravirine and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Pifeltro. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Pifeltro.
Blood sugar: Doravirine may cause an increase in blood sugar levels (may cause a loss of blood glucose control) and glucose tolerance may change. People with Diabetes may find it necessary to monitor their blood sugar more frequently while using Pifeltro.
If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Pifeltro may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Pifeltro, and whether any special monitoring is needed.
Cholesterol: Doravirine can cause increased blood cholesterol levels. If you are at risk of developing High Cholesterol or you have high cholesterol levels before starting doravirine, discuss with your doctor how Pifeltro may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Pifeltro, and whether any special monitoring is needed.
Drowsiness/reduced alertness: Doravirine may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by Pifeltro.
Immune reconstitution syndrome: Pifeltro may cause immune reconstitution syndrome, where signs and symptoms of inflammation from previous infections appear. These symptoms occur soon after starting anti-HIV medication and can vary. They are thought to occur as a result of the immune system improving and being able to fight infections that have been present without symptoms (such as pneumonia, herpes, or Tuberculosis). Report any new symptoms to your doctor immediately.
Stopping the medication: If you stop taking Pifeltro, your HIV infection could get worse. Take the medication exactly as prescribed by your doctor, and do not stop taking the medication without checking with your doctor first.
Pregnancy: Pifeltro should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Pifeltro, contact your doctor immediately.
Breast-feeding: It is not known if doravirine passes into breast milk. Women who have HIV infection should not breast-feed because of the risk of passing HIV to a baby who does not have the infection.
Children: The safety and effectiveness of using Pifeltro have not been established for children.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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