Zyloprim

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Zyloprim (Allopurinol). If you are concerned about side effects, discuss the risks and benefits of Zyloprim (Allopurinol) with your doctor.

The following side effects have been reported by at least 1% of people taking Zyloprim (Allopurinol). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Diarrhea
• dizziness
• drowsiness
• headache
• indigestion
• nausea or vomiting occurring without other side effects
• stomach pain occurring without other side effects
• hair loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• numbness, tingling, pain, or weakness in hands or feet
• signs of Anemia (low red blood cells; e.g., dizziness,  pale skin, unusual tiredness or weakness, shortness of breath)
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood,  bleeding gums, cuts that don’t stop bleeding)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour, rapid weight gain)
• swelling of face, fingers, feet, or lower legs
• vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chills, Fever, muscle aches or pains, nausea, or vomiting (especially if this happens with or shortly after a skin rash)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Zyloprim (Allopurinol).

100 mg
Each white, round, biconvex, scored tablet engraved with "ALL" over "100" on one side contains 100 mg of Zyloprim (Allopurinol). Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, and colloidal silicon dioxide.

200  mg
Each peach, round, biconvex, scored tablet engraved with "ALL" over "200" on one side contains 200 mg of Zyloprim (Allopurinol). Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and Sunset Yellow Aluminium Lake.

300 mg
Each orange, round, biconvex, scored tablet engraved with "ALL" over "300" on one side contains 300 mg of Zyloprim (Allopurinol). Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and Sunset Yellow Aluminium Lake.

Do not take Zyloprim (Allopurinol) if you:

• are allergic to Zyloprim (Allopurinol) or any ingredients of Zyloprim (Allopurinol)
• have previously developed a severe reaction to Zyloprim (Allopurinol) or any ingredients of Zyloprim (Allopurinol)
• are a child (except to treat high levels of uric acid caused by cancer)
• are a nursing mother (except to treat high levels of uric acid caused by cancer)

There may be an interaction between Zyloprim (Allopurinol) and any of the following:

• aluminum salts (e.g., antacids containing aluminum)
• ampicillin
• amoxicillin
• angiotensin-converting enzyme inhibitors (ACEIs; Captopril, Ramipril)
• antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
• Azathioprine
• Bendamustine
• Bleomycin
• Carbamazepine
• chlorpropamide
• Cyclophosphamide
• Cyclosporine
• didanosine
• diuretics (e.g., Furosemide, hydrochlorthiazide)
• Mercaptopurine
• Phenytoin
• salicylates (e.g., Asa)
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Zyloprim (Allopurinol). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Zyloprim (Allopurinol).

Drowsiness/reduced alertness: Zyloprim (Allopurinol) may cause drowsiness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by Zyloprim (Allopurinol).

Use appropriate caution if you plan to do activities requiring alertness.

Gout: Do not start Zyloprim (Allopurinol) treatment until an acute attack of gout has completely subsided, as further attacks may be caused by Zyloprim (Allopurinol). Acute gout attacks may occur at the start of treatment with Zyloprim (Allopurinol) for people who have not taken the medication before. If an acute gout attack develops after starting Zyloprim (Allopurinol), call your doctor.

Hypersensitivity syndrome: A Anaphylaxis (severe allergic reaction) called hypersensitivity syndrome has occurred for some people with the use of Zyloprim (Allopurinol). This reaction involves a number of organs in the body and may be fatal if not treated quickly. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.

Kidney function: Kidney Disease or reduced kidney function may cause Zyloprim (Allopurinol) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Zyloprim (Allopurinol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zyloprim (Allopurinol), and whether any special monitoring is needed.

Liver function: Zyloprim (Allopurinol) may reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how Zyloprim (Allopurinol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zyloprim (Allopurinol), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Zyloprim (Allopurinol).

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Skin rash: If you develop a skin rash, stop taking Zyloprim (Allopurinol) and contact your doctor. The skin rash may be the first sign of a serious allergic reaction to the medication.

Pregnancy: Zyloprim (Allopurinol) is not recommended for women who are or may become pregnant unless the potential benefits outweigh the possible risks. If you are or may be pregnant, talk to your doctor about the risks and benefits of Zyloprim (Allopurinol).

Breast-feeding: Zyloprim (Allopurinol) passes into breast milk. If you are a breast-feeding mother and are taking Zyloprim (Allopurinol), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Children should not take Zyloprim (Allopurinol), except in cases where increased uric acid levels in the blood are associated with cancer or with Lesch-Nyhan syndrome. The safety and effectiveness of Zyloprim (Allopurinol) for this age group have not been established in treatment of other conditions.