Frovatriptan

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Frovatriptan. If you are concerned about side effects, discuss the risks and benefits of Frovatriptan with your doctor.

The following side effects have been reported by at least 1% of people taking Frovatriptan. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• decreased sensation of touch
• dizziness
• Dry Mouth
• fatigue
• feelings of (in any part of the body):
• coldness
• heat
• numbness
• tingling
• warmth
• weakness
• flushing
• headache (other than migraine)
• indigestion
• muscle aches or weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• increased blood pressure
• skin rash, Hives, itching, or bumps on skin
• slow, fast, or pounding heartbeat
• vision changes (usually temporary)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• convulsions (seizures)
• heart attack (symptoms include pain, pressure, tightness, or heaviness in the chest, jaw, neck or shoulder, sweating, or shortness of breath)
• lower abdominal pain or severe rectal bleeding (blood in the stool or black, tarry stools)
• Anaphylaxis (severe allergic reaction) (symptoms include: swelling of the face or throat, hives, difficulty breathing)
• stroke (symptoms include: sudden numbness or weakness, especially on one side of the body; sudden confusion or problems with speech; sudden vision problems in one or both eyes; sudden dizziness or loss of coordination; sudden severe headache, especially if it seems different from your usual headaches)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Frovatriptan.

Each round, white, film-coated tablet debossed with "2.5" on one side and "E" on the other contains 2.5 mg of frovatriptan (base) as the succinate. Nonmedicinal ingredients: colloidal silicon dioxide NF, hydroxypropylmethylcellulose USP, lactose NF, magnesium stearate NF, microcrystalline cellulose NF, polyethylene glycol 3000 USP, sodium starch glycollate NF, triacetin USP, titanium dioxide USP, and triacetin USP.

Do not take Frovatriptan if you:

• are allergic to frovatriptan or any ingredients of the medication
• do not have a clear diagnosis of migraine
• have Angina (chest pain), including Prinzmetal's angina (coronary vasospasm)
• have blood vessel disease (e.g., ischemic bowel disease, Raynaud's syndrome, Stroke, transient ischemic attacks (TIAs))
• have certain types of migraine headaches (including hemiplegic, basilar, or ophthalmoplegic migraine)
• have had a Heart Attack
• have heart disease (e.g., heart valve disease, ischemic heart disease, abnormal heart rhythms, congenital heart disease)
• have high blood pressure that is severe or not under control
• have severely reduced liver function
• have taken another 5-hydroxytryptamine agonist (i.e., Naratriptan, Rizatriptan, Zolmitriptan) in the previous 24 hours
• have taken ergotamine-containing or ergot-type medications (such as Dihydroergotamine, ergotamine, or methysergide) in the previous 24 hours

There may be an interaction between frovatriptan and any of the following:

• amphetamines (e.g., Dextroamphetamine, lisdexamphetamine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, olanzepine, Quetiapine, Risperidone)
• Bromocriptine
• Buspirone
• Cabergoline
• Cyclobenzaprine
• Dextromethorphan
• ergot-containing medications (e.g., dihydroergotamine, ergotamine, or methysergide), if taken at the same time or within the previous 24 hours
• Linezolid
• lithium
• Metoclopramide
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Maprotiline, Moclobemide, Selegiline, Tranylcypromine)
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• other 5-hydroxytryptamine agonists (e.g., rizatriptan, naratriptan, zolmitriptan) if taken at the same time or within the previous 24 hours
• Propranolol
• St. John's wort
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, venlafaxine)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Paroxetine, Fluoxetine, Sertraline, Fluvoxamine)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• Tapentadol
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Desipramine, Imipramine)
• Tryptophan

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Frovatriptan. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Frovatriptan.

Allergy: People allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) can also have an allergic reaction to frovatriptan. If you are allergic to any of these medications, you should not take frovatriptan unless advised to do so by your doctor.

Blood pressure: Frovatriptan may cause an increase in blood pressure. If you have high blood pressure, discuss with your doctor how Frovatriptan may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Frovatriptan, and whether any special monitoring is needed. People with severe or uncontrolled high blood pressure should not take frovatriptan.

Drowsiness/reduced alertness: Frovatriptan may cause drowsiness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how Frovatriptan affects you.

Heart disease and stroke: Frovatriptan may cause narrowing of the blood vessels that supply the heart. This can lead to chest pain, heart attacks, Arrhythmias (irregular heartbeat), and other heart problems. There have also been reports of bleeding in the brain and stroke with Frovatriptan. For this reason, frovatriptan should not be used by people with heart or blood vessel disease. If you have certain risk factors for heart disease (e.g., high blood pressure, High Cholesterol, smoking, Obesity, Diabetes, family history of Coronary Artery Disease, Menopause, men over 40 years of age), tell your doctor.

Medication overuse headaches: As with other medications used to treat headache pain, taking frovatriptan too frequently may cause headaches to recur as the medication wears off. If you find that headaches return frequently, you may be taking too much of Frovatriptan. This situation should be discussed with your doctor.

Seizures: If you have seizures or a history of seizure disorder, discuss with your doctor how Frovatriptan may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Frovatriptan, and whether any special monitoring is needed.

Serotonin syndrome: Frovatriptan may cause a rare but potentially life-threatening condition called serotonin syndrome, especially when used with other medications that increase serotonin levels (e.g., Sumatriptan, rizatriptan, certain antidepressants, St. John's wort, sibutramine, Venlafaxine). If you experience symptoms such as agitation, confusion, hallucinations, fast heart rate, Fever, lack of coordination, increased body temperature, overactive reflexes, nausea, vomiting, and Diarrhea, get immediate medical attention.

Pregnancy: Frovatriptan should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Frovatriptan, contact your doctor immediately.

Breast-feeding: It is not known if frovatriptan passes into breast milk. If you are a breast-feeding mother and are taking Frovatriptan, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Frovatriptan have not been established for children less than 18 years of age.

Seniors: There is limited experience with the use of frovatriptan by people over 65 years of age. The use of Frovatriptan by seniors is not recommended.

Frovatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine Headaches with or without aura (warning signs that occur prior to the onset of a migraine) in adults. The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Frovatriptan relieves migraine headaches by constricting these blood vessels.

Frovatriptan is not recommended for other types of headache or for headache prevention.

Frovatriptan may be available under multiple brand names and/or in several different forms. Any specific brand name of Frovatriptan may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Frovatriptan may not be used for all of the conditions discussed here.

Your doctor may have suggested Frovatriptan for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Frovatriptan, speak to your doctor. Do not stop taking Frovatriptan without consulting your doctor.

Do not give Frovatriptan to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Frovatriptan if their doctor has not prescribed it.