Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses Buscopan (Hyoscine-butylbromide). If you are concerned about side effects, discuss the risks and benefits of Buscopan (Hyoscine-butylbromide) with your doctor.

The following side effects have been reported by at least 1% of people using Buscopan (Hyoscine-butylbromide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• blurred vision that is temporary
• Constipation
• decreased ability to sweat
• Diarrhea
• dizziness
• Dry Mouth
• fast heartbeat
• flushing
• nausea

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• difficulty urinating
• dizziness or lightheadedness when getting up from a lying or sitting position
• shortness of breath
• skin rash and itching
• vision changes

Stop using the medication and seek immediate medical attention if any of the following occur:

• painful red eye with loss of vision
• symptoms of a Anaphylaxis (severe allergic reaction) (e.g., Hives; difficulty breathing; swelling of the face, mouth, tongue, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Buscopan (Hyoscine-butylbromide).

Tablets
Each round, white, sugar-coated tablet contains 10 mg of hyoscine butylbromide. Nonmedicinal ingredients: acacia, anhydrous dibasic calcium phosphate, carnauba wax, colloidal silicon dioxide, corn starch, modified starch, polyethylene glycol 6000, povidone, stearic acid, sucrose, talc, tartaric acid, titanium dioxide, and white wax.

Injection
Each mL contains 20 mg of hyoscine butylbromide. Nonmedicinal ingredients: sodium chloride and water for injection.

Do not use Buscopan (Hyoscine-butylbromide) if you:

• are allergic to hyoscine or any ingredients of Buscopan (Hyoscine-butylbromide)
• are allergic to other atropinics (e.g., atropine, scopolamine)
• have Myasthenia Gravis
• have megacolon (enlarged colon)
• have Glaucoma
• have obstructive prostatic hypertrophy (enlarged or blocked prostate)

In addition, do not use the injection form of Buscopan (Hyoscine-butylbromide) if you:

• are receiving Buscopan (Hyoscine-butylbromide) as an intramuscular injection and are taking a blood thinner medication (e.g., Warfarin, Heparin)
• have narrowing of the gastrointestinal tract
• have a fast heartbeat
• have Angina
• have heart failure

There may be an interaction between hyoscine and any of the following:

• aclidinium
• alcohol
• amantadine
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• atropine
• Baclofen
• barbiturates (e.g., butalbital, pentobarbital Phenobarbital)
• belladonna
• benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
• Benztropine
• botulinum toxin
• brimonidine
• Buprenorphine
• Buspirone
• chloral hydrate
• Darifenacin
• Disopyramide
• Donepezil
• efavirenz
• Flavoxate
• Galantamine
• general anesthetics (medications used to put people to sleep before surgery)
• Glucagon
• glycopyrrolate
• ipratropium
• ketotifen
• magnesium sulfate
• MAO inhibitors (e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• Metoclopramide
• Mirabegron
• Mirtazapine
• muscle relaxants (e.g., Cyclobenzaprine, methocarbamol, orphenadrine)
• Nabilone
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• Olopatadine
• Oxybutynin
• potassium chloride
• Pramipexole
• quinidine
• Rivastigmine
• Ropinirole
• scopolamine
• seizure medications (e.g., Clobazam, Levetiracetam, phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• Solifenacin
• Tapentadol
• thalidomide
• thiazide diuretics (water pills; e.g., Hydrochlorothiazide, Indapamide, Metolazone)
• tiotropium
• Tolterodine
• Tramadol
• tricyclic antidepressants (e.g., Amitriptyline, Desipramine, Nortriptyline)
• umeclidinium
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Buscopan (Hyoscine-butylbromide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Buscopan (Hyoscine-butylbromide).

Difficulty urinating: Buscopan (Hyoscine-butylbromide) may make it more difficult for you to urinate. If you have an enlarged prostate, urinary retention, or difficulty urinating, discuss with your doctor how Buscopan (Hyoscine-butylbromide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Buscopan (Hyoscine-butylbromide), and whether any special monitoring is needed.

Fructose intolerance: Fructose intolerance is a rare condition in which fructose (a type of sugar) is not broken down by the body. One sugar-coated tablet of 10 mg contains 41.2 mg of sucrose, which can result in 411.8 mg of sucrose per day if the maximum recommended daily dose of hyoscine is needed. You should not use Buscopan (Hyoscine-butylbromide) if you have fructose intolerance.

Glaucoma: Buscopan (Hyoscine-butylbromide) may cause the symptoms of glaucoma (increased pressure in the eye) to develop or become worse. If you have glaucoma, discuss with your doctor how Buscopan (Hyoscine-butylbromide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Buscopan (Hyoscine-butylbromide), and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Buscopan (Hyoscine-butylbromide).

Heart problems: Buscopan (Hyoscine-butylbromide) can increase your heart rate. If you have tachycardia (a fast heart rate), heart disease, an abnormal heart rhythm, heart failure, or mitral stenosis (a heart valve problem), discuss with your doctor how Buscopan (Hyoscine-butylbromide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Buscopan (Hyoscine-butylbromide), and whether any special monitoring is needed.

Stomach and intestinal problems: If you have reflux esophagitis, a medical condition that narrow or blocks the intestines (e.g., achalasia, pyloroduodenal stenosis), or Ulcerative Colitis, discuss with your doctor how Buscopan (Hyoscine-butylbromide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Buscopan (Hyoscine-butylbromide), and whether any special monitoring is needed.

Vision problems: Buscopan (Hyoscine-butylbromide) may affect your vision. Do not drive or operate machinery until any vision problems have resolved. If you receive Buscopan (Hyoscine-butylbromide) during a diagnostic procedure, you should arrange for someone to drive you home from the hospital or clinic after your procedure.

Get immediate medical attention if you experience a painful red eye with loss of vision.

Pregnancy: Buscopan (Hyoscine-butylbromide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using Buscopan (Hyoscine-butylbromide), contact your doctor immediately.

Breast-feeding: It is not known if hyoscine passes into breast milk. If you are a breast-feeding mother and are using Buscopan (Hyoscine-butylbromide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Buscopan (Hyoscine-butylbromide) have not been established for children.

Seniors: Seniors are more sensitive to the side effects of Buscopan (Hyoscine-butylbromide), especially constipation, dry mouth, and difficulty urinating. If you experience any of these side effects and they continue or are severe, contact your doctor.