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Zaroxolyn

Zaroxolyn

Metolazone

Zaroxolyn (Metolazone) belongs to the class of medications called diuretics. It is used to treat blood pressure and to remove excessive water (edema) that occurs in such conditions as Congestive Heart Failure and some forms of Kidney Disease.

Available form

Tablet

Dosage

2.5mg, 5mg, 10mg

Manufacturers

Aventis Pharma, Sanofi-aventis

Generic brand of

Metolazone

Buy Zaroxolyn Full drug details

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Zaroxolyn information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose of Zaroxolyn (Metolazone) ranges from 2.5 mg to 20 mg daily depending on the condition being treated and the circumstances of the person taking the medication. For treatment of high blood pressure, the usual dose is 2.5 mg to 5 mg once daily. For treatment of edema, the usual dose ranges from 5 to 20 mg once daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Zaroxolyn (Metolazone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Zaroxolyn (Metolazone). If you are concerned about side effects, discuss the risks and benefits of Zaroxolyn (Metolazone) with your doctor.

The following side effects have been reported by at least 1% of people taking Zaroxolyn (Metolazone). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

decreased sexual ability
Diarrhea
dizziness or lightheadedness when getting up from a lying or sitting position
fatigue
increased sensitivity of skin to sunlight
loss of appetite
upset stomach

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

flu-like symptoms (e.g., Fever or chills, sore throat, cough, achiness)
joint pain
skin rash or Hives
signs and symptoms of too much potassium loss:

dryness of mouth
increased thirst
irregular heartbeat
mood or mental changes
muscle cramps or pain
nausea or vomiting
unusual tiredness or weakness
weak pulse

signs and symptoms of too much sodium loss:

confusion
convulsions
decreased mental activity
irritability
muscle cramps
unusual tiredness or weakness

signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Zaroxolyn (Metolazone).

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Zaroxolyn (Metolazone).

Diabetes: If you have diabetes, your doctor should closely monitor your condition while you are taking Zaroxolyn (Metolazone), as it may affect blood sugar control (by increasing blood sugar levels).

Electrolytes: Zaroxolyn (Metolazone) may cause imbalances of electrolytes in the blood such as potassium, sodium, and magnesium. The signs of electrolyte imbalance include:

drowsiness
Dry Mouth
lethargy
Low Blood Pressure
muscle fatigue
muscle pains or cramps
racing heart rate
reduced urine output
restlessness
stomach disturbances such as nausea and vomiting
thirst
weakness

If you have these symptoms, contact your doctor as soon as possible.

Gout: High blood uric acid levels may be brought on by Zaroxolyn (Metolazone). This may result in a gout attack for people with a history of gout. If you have a history of gout, discuss with your doctor how Zaroxolyn (Metolazone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zaroxolyn (Metolazone), and whether any special monitoring is needed.

Kidney and liver function: If you have reduced kidney or liver function, discuss with your doctor how Zaroxolyn (Metolazone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zaroxolyn (Metolazone), and whether any special monitoring is needed.

Low blood pressure: Some people taking Zaroxolyn (Metolazone) experience sudden blood pressure drops when getting up from a sitting or lying position. These blood pressure drops could lead to dizziness, lightheadedness, and falls. If you experience this problem, try getting up more slowly. If it persists or if you faint, contact your doctor.

Systemic Lupus erythematosus: Zaroxolyn (Metolazone) can worsen or activate the symptoms of lupus. If you experience swollen and painful joints, fever, fatigue, or rash on the nose and cheeks while taking Zaroxolyn (Metolazone), contact your doctor.

Pregnancy: Zaroxolyn (Metolazone) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Zaroxolyn (Metolazone), contact your doctor immediately.

Breast-feeding: Zaroxolyn (Metolazone) passes into breast milk. If you are a breast-feeding mother and are taking Zaroxolyn (Metolazone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Zaroxolyn (Metolazone) have not been established for children.

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All material © 1996-2025 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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