Prevymis 480

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Available Form:  

INJECTABLE

Manufacturer name:  

Merck

Strength:  

20MG/ML

What is Prevymis 480?

Letermovir belongs to the class of medications called antivirals. It is used to prevent infection caused by cytomegalovirus (CMV) for adults who have had a stem cell transplant with cells from another person, who are at risk of developing CMV infection.

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Prevymis 480 frequently asked questions

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Prevymis 480 in Canada?

Shipping cost for Prevymis 480 to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Prevymis 480 delivered to my home?

You could get Prevymis 480 delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Prevymis 480 in Canada for free?

You can get Prevymis 480 for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Prevymis 480 for free.

Prevymis 480 How to Take

Letermovir belongs to the class of medications called antivirals. It is used to prevent infection caused by cytomegalovirus (CMV) for adults who have had a stem cell transplant with cells from another person, who are at risk of developing CMV infection.

Letermovir works by preventing CMV from reproducing and spreading, causing infection.

Prevymis 480 may be available under multiple brand names and/or in several different forms. Any specific brand name of Prevymis 480 may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Prevymis 480 may not be used for all of the conditions discussed here.

Your doctor may have suggested Prevymis 480 for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Prevymis 480, speak to your doctor. Do not stop taking Prevymis 480 without consulting your doctor.

Do not give Prevymis 480 to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Prevymis 480 if their doctor has not prescribed it.

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Prevymis 480 Dosage

There are two forms of Prevymis 480: tablets and solution for intravenous (into a vein) infusion.

The recommended adult dose of letermovir is 480 mg taken by mouth, once daily. It should be started on or after the day you receive the stem cell transplant, but no later than 28 days after the transplant. It is generally taken until 100 days after the transplant.

The tablets should be taken at approximately the same time each day. Swallow the tablets whole with some fluid. Do not crush or chew the tablets. Letermovir may be taken with food or on an empty stomach.

If you are receiving the intravenous form of Prevymis 480, it will take approximately 1 hour for the infusion to complete.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Prevymis 480 exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Prevymis 480 in its original package at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Prevymis 480 Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Prevymis 480. If you are concerned about side effects, discuss the risks and benefits of Prevymis 480 with your doctor.

The following side effects have been reported by at least 1% of people taking Prevymis 480. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • Diarrhea
  • nausea
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • rapid heartbeat
  • symptoms of irregular heartbeat (e.g., chest pain, dizziness, rapid, pounding heartbeat, shortness of breath)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Prevymis 480.

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Prevymis 480 Available Form

Tablets

240 mg
Each yellow oval tablet, debossed with "591" on one side and the Merck logo on the other side contains 240 mg of letermovir. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose and povidone 25; film-coating: hypromellose 2910, iron oxide yellow, lactose monohydrate, titanium dioxide, triacetin, and carnauba wax.

480 mg
Each pink, oval, bi-convex tablet, debossed with "595" on one side and the Merck logo on the other side, contains 480 mg of letermovir. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose and povidone 25; film-coating: hypromellose 2910, iron oxide yellow, iron oxide red, lactose monohydrate, titanium dioxide, triacetin, and carnauba wax.

Solution for Injection

Each mL of clear, preservative-free sterile solution in single dose vials of either 240 mg or 480 mg per vial, contains 20 mg of letermovir. Nonmedicinal ingredients: hydroxypropyl betadex, sodium chloride, sodium hydroxide and water for injection. The amount of sodium hydroxide may be adjusted to achieve a pH of approximately 7.5.

Prevymis 480 Contraindications

Do not take Prevymis 480 if you:

  • are allergic to letermovir or any ingredients of the medication
  • are taking the medication Pimozide
  • are taking ergotamine or Dihydroergotamine for migraines
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Prevymis 480 Precautions

There may be an interaction between letermovir and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Prevymis 480. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Prevymis 480 Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Prevymis 480.

Kidney function: Decreased kidney function or Kidney Disease may cause Prevymis 480 to build up in your body, causing side effects. If you have kidney problems, discuss with your doctor how Prevymis 480 may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Prevymis 480, and whether any special monitoring is needed.

Liver function: Decreased liver function or liver disease may cause Prevymis 480 to build up in your body, causing side effects. If you have liver problems, discuss with your doctor how Prevymis 480 may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Prevymis 480, and whether any special monitoring is needed.

Pregnancy: Prevymis 480 should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Prevymis 480, contact your doctor immediately.

Breast-feeding: It is not known if letermovir passes into breast milk. If you are a breast-feeding mother and are taking Prevymis 480, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Prevymis 480 have not been established for children.

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References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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