What is Tepmetko?
Health Canada has approved Tepmetko for the treatment of NSCLC with METex14 skipping alterations. It is the first and only once-daily oral medicine for this condition.
MET exon 14 (METex14) skipping alterations (type of gene alterations) are found in 3% to 5% of NSCLC cases, making their treatment extremely challenging.
Lung cancer is the most common type of cancer in Canada as well as globally. And about 85% of these cancers are non-small cell lung cancer (NSCLC), a group of lung cancer that behave similarly.
What is Tepmetko used for?
What are the label uses of Tepmetko?
Tepmetko or Tepotinib is a prescription medication used to treat certain types of non-small cell lung cancer (NSCLC) that are unreseactable or has spread to other body parts.
PS: “This use is permitted under accelerated approval based on response. Continued approval for this indication may be conditional upon verification of clinical benefit in study trials.”
What are the off-label uses of Tepmetko?
There is no off-label use of the medicine so far.
It may be prescribed for other uses; ask your doctor or pharmacist for more information.
How to use Tepmetko?
- The recommended dose is 450 mg once daily with food.
- The medication is to be continued until disease progression or unacceptable toxicity.
- However, the use and dose of the medicine may be different for everyone and thus shouldn’t be taken without consulting your doctor.
- In case of a missed dose, take Tepmetko as soon you remember it. However, if it is within 8 hours of the next dose, you can skip the dose and continue your regular dosing schedule.
- If vomiting occurs after Tepmetko consumption, take the next dose at the scheduled time.
- Do not take a double dose.
- Take this medicine at the same time every day. Swallow the tablets, do not crush, chew or split the tablet.
What are the ingredients of Tepmetko?
Tepotinib hydrochloride hydrate is an active ingredient in Tepmetko.
It belongs to the kinase inhibitors class of medication, which acts by blocking the action of an abnormal protein that supports cancer cells to multiply, thus helping in slowing or stopping the spread of cancer.
How to store and dispose of Tepmetko?
- Store Tepmetko between 20° to 25°C.
- Keep it away from the reach of children and pets.
- Do not discard the medicine through household waste or wastewater.
What are the side effects of Tepmetko?
Like all the medications, Tepmetko also has side effects. It is possible that you may experience the following side effects. Inform your physician if these symptoms are severe or if they do not do away;
- Muscle, joint, or bone pain
- Swelling of the arms, hands, feet, or lower legs
- Abdominal pain
- Loss of appetite
Some of these effects may be serious. If you experience any of them, please get in touch with your physician immediately;
- Shortness of breath
- Fever or cough
- Pain in the upper part of the stomach
- Unusual bruise or bleeding
- Dark urine
- Yellowing of skin and eyes
- Loss of Appetite
- Decreased albumin
- Decreased sodium
- Decreased hemoglobin
This is not a complete list. If you experience serious side effects or symptoms that are persistent, please contact your health worker immediately.
What are the most important contraindications of Tepmetko?
Inform your healthcare provider in case of an allergy to Tepmetko or any of the ingredients. Ask your pharmacist for the list of the ingredients.
Do not take or inform your doctor if you have or had following conditions;
- Breathing Problems
- Lung diseases
- Interstitial Lung Disease
- Liver disease
Besides, inform your doctor if you are pregnant or breastfeeding, or planning to be pregnant. You should not become pregnant while you are taking Tepmetko. You need to undergo a pregnancy test before you start the treatment. You should use birth control methods to prevent pregnancy while you are on treatment and about a week after your final dose.
If you are breastfeeding, inform your doctor immediately and should not breastfeed while you are on treatment and a week after your final dose.
Tepotinib may harm your fetus. Call your doctor immediately if you or your partner become pregnant during the course of the treatment.
What are some warnings and precautions while on Tepmetko?
Inform your health worker about other prescription and non-prescription medications that you are taking. Also, inform about vitamins, herbal and nutritional supplements that you are taking or planning to take.
If you are male with a female partner who may become pregnant, you should contraceptives to prevent pregnancy while you are on treatment and at least one week after your final dose.
Talk to your doctor to know the best possible birth control methods that will suit you.
What are Tepmetko interactions?
Tipotinib may interact with any of the following medications or inform your doctor if you are taking any of the below-mentioned medication:
- Tenofovir df
- Vincristine liposomal
- Brentuximab vedotin
The list is not comprehensive, and other drugs may interact with Tepmetko. You should mention all the medicines that you are taking and consult your doctor before starting any medication.
How to Store Tepmetko?
Store in original package. Store at 20-25 ºC (68-77ºF); excursion permitted to 15-30ºC (59-86ºF)
Is There A Generic Version to Tepmetko?
No. For now, there is no therapeutically equivalent version of Tepmetko available in Canada.
How Is Tepmetko Different from Others In The Treatment Of Ailment?
According to the results of various studies, Tepmetko is the one and the only drug of its kind that is available as once-daily oral medicine for the treatment of non-small cell lung cancer (NSCLC)
Who makes Tepmetko and What Is Their Manufacturing Record of Success?
Merk, a Germany-based science and technology company, has come up with Tepmetko. The product has a highly selective mechanism of action, potentially improving outcomes in aggressive tumors that have a poor prognosis due to specific gene alterations.