What is Stribild?
Stribild is a prescription medication that is a combination of four drugs Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir. Stribild is an antiretroviral drug indicated to treat human immunodeficiency virus - 1 (HIV-1) infections in adults and children (12 years and above) who have not been treated with other HIV medications or replace the current medication therapy certain individuals already taking HIV medications. Stribild can be used with or without other antiretroviral agents to treat HIV-1.
Let us understand more about the medication, including its uses, side effects, and precautions to be followed.
How to use Stribild?
What are the approved label uses of Stribild?
- Stribild is used to treat HIV-1 infections in adults and children who have not been treated with other HIV medications or replace the current medication therapy in certain individuals already taking HIV medications. Stribild helps to lower your chance of getting HIV related complications and improves the quality of life
- Stribild will not cure HIV; however, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV related illness
- Taking Stribild and practicing safer sex (using barrier method), and making other lifestyle changes (not sharing personal items such as toothbrushes, syringes, or other body fluids) could decrease the risk of HIV transmission to other people
What are some off-label uses of Stribild?
There is no off-label use of the medicine so far.
It may be prescribed for other uses; ask your doctor or pharmacist for more information.
What are the instructions for Stribild?
The following instructions should be followed while consuming Stribild:
- Stribild is available as a tablet that is to be taken orally. The medication must be taken with food.
- It is to be taken once a day. Take the medication at the same time every day.
- Take this medication regularly to get the maximum response to the treatment. Do not stop the treatment even if you feel well.
- Talk to a pediatrician regarding the use of this medication in children. The drug is approved and is being prescribed for children 12 years and above. However, precautions do apply.
- Do not stop taking the medication without consulting with your doctor. Follow the instructions on the prescription label and ask your physician or pharmacist if you have any queries regarding the dosing.
- Follow your regular diet unless advised by your doctor.
- Skipping doses may make the virus resistant to this medication and other medicines.
If you miss your dose, take the dose as soon as you remember with food. However, if it is almost the time of the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the missed dose.
What are the ingredients in Stribild?
Stribild is available as a tablet that contains 150 mg Elvitegravir, 150 mg Cobicistat, 200 mg Emtricitabine, and 245 mg Tenofovir disoproxil (equivalent to 300 mg of tenofovir disoproxil fumarate).
Elvitegravir belongs to human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor class of drugs.
Emtricitabine and Tenofovir belong to the nucleoside reverse transcriptase inhibitors (NRTIs) class of drugs.
Elvitegravir, Emtricitabine, and Tenofovir work by decreasing the amount of HIV in the blood. On the other hand, Cobicistat helps to keep Elvitegravir for a more extended period in the body to produce a more significant effect.
How to store and dispose of Stribild?
- Dispense and store Stribild in original container
- Stribild can be stored at room temperature between 15°C to 30°C
- Do not throw desiccant away from the bottle
- Keep it away from sunlight
- Keep it away from moisture
- Keep the container tightly closed
Keep the medication out of sight and reach of children and pets.
Unused, unneeded, or expired medication should be disposed of in special ways to ensure that children, pets, and other people do not consume them. You should not flush the medication in the toilet. The best way to dispose of medication is through a medication take-back program. Talk to your healthcare professional to learn more about the take-back program.
What are the side effects of Stribild?
Like all the medications, Stribild also has side effects. It is possible that you may not experience any side effects or may experience minor side effects. Inform your doctor if any of the below mentioned side effects are severe or do not go away:
- Difficulty falling asleep or staying asleep
- Unusual dreams
Some of the side effects can be serious. If you experience any of these symptoms, inform your physician immediately:
- Dark or yellow urine
- Yellowing of skin
- Yellowing of eyes
- Decreased in urination
- Fast heartbeat
- Irregular heartbeat
- Muscle pain
- Loss of appetite
- Extreme tiredness
- Unusual bleeding or bruising
- Flu-like symptoms
- Feeling cold, especially in arms or legs
- Pain in the upper right part of the stomach
- Breathing difficulties
- Light-colored bowel
Stribild may cause other side effects. Call your physician if you experience any unusual problems while on this medication.
What are the most important contraindications when on Stribild?
Tell your physician or pharmacist about it if you are allergic to Elvitegravir, Cobicistat, Emtricitabine, Tenofovir, or any of its ingredients. If you have any other allergies, do not forget to share the same with the healthcare professional.
Do not take or inform your doctor if you have or had following conditions:
- Liver disease
- Kidney disease Bone problems
- Cytomegalovirus (a viral infection that may cause symptoms in patients with weak immune systems)
- Osteoporosis (a disease of the bones in which they become weak, thin, and can break easily)
- Any recurring infection (e.g., Tuberculosis)
Inform your doctor if you are pregnant or breastfeeding or if you are thinking of getting pregnant. If you become pregnant while on treatment, call your doctor immediately as Stribild. Lastly, you should not breastfeed if you are HIV infected or taking Stribild.
What are the warnings and precautions of Stribild?
Patients with HIV-1 should be tested for the presence of Hepatitis B virus before initiating antiretroviral therapy. Inform your health worker about other prescription, non-prescription medications, and nutritional supplements that you are taking. Also, inform about vitamins and herbal supplements you are taking or planning to take.
Lactic acidosis and liver toxicity are two severe reactions associated with Stribild, especially if you are a female or obese or have been taking HIV medications for a long time.
If you take antacids, you should take antacids 2 hours before the medication or 2 hours after the medication.
Stribild may slightly make you feel dizzy, drowsy, or unable to concentrate, so do not drive a car or operate machinery until you know how the medication affects you.
Your immune system may get stronger and fight other infections already present in the body. However, this may cause you to develop other infections or symptoms.
What are the most important interactions of Stribild?
Inform your health worker about other prescription, non-prescription medications, and nutritional supplements that you are taking. Also, inform about vitamins and herbal supplements you are taking or planning to take.
Stribild may interact with any of the following medications or inform your doctor if you are taking any of the below-mentioned medication:
- Ergot containing medications
- St John’s wort
- Alfuzosin hydrochloride
The list mentioned above is not comprehensive, and other drugs may interact with Stribild. You should mention all the medications you are taking and consult your doctor before starting the medication.
Can I take Oral Contraceptive Pills While Taking Stribild?
It is not recommended to use oral contraceptive pills while taking Stribild as it interferes with contraceptive pills and decreases its efficacy. You should use the barrier method of birth control or ask your doctor to help you choose an appropriate method of birth control that will suit you.
When can I Take Stribild?
Stribild can be taken any time of the day. It would help if you consumed it at a fixed time so that remembering it becomes easy. It is to be taken with food.
If you take antacids, you need to take Stribild 2 hours before or after the antacid consumption.
Is There A Generic Version to Stribild?
No. For now, there is no therapeutically equivalent version of Triumeq available in Canada.
How Is Stribild Different from Others In The Treatment Of Ailment?
Stribild and Genvoya are antiviral drugs with the same combination of four drugs: Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir. Both are indicated as a complete regime for the treatment of HIV-1 infection.
The difference between both drugs is regarding Tenofovir contained in each product. Genvoya contains Tenofovir Alafenamide (TAF) 10 mg while Stribild contains Tenofovir disoproxil fumarate (TDF) 300 mg.
TAF is recent and more efficient than TDF, and it can be administered at a much lower dose than TDF. Also, TAF appears to cause less kidney toxicity and decreased bone density compared to TDF. Stribild came first into the market, followed by Genvoya.
Who Makes Stribild and What Is Their Manufacturing Record of Success?
Gilead Sciences, a biopharmaceutical company, has come up with Truvada. They mainly focus their research and development of drugs to treat HIV, hepatitis B, hepatitis C, and influenza.