What is Ponvory
Ponvory is an oral, once-daily pill, unlike injection or infusion that are commonly used to manage multiple sclerosis.
Let’s understand more about the medication, including its uses, side effects, and precautions to be followed.
How to use Ponvory
Ponvory or Ponesimod is an oral prescription medication indicated in treating relapsing forms of multiple sclerosis (a disease in which the immune system damages the protective covering of nerves).
Damage to the nerves often disrupts their functioning and results in weakness, loss of muscle coordination, numbness, and problems with vision, bladder control and speech.
What are some label uses of Ponvory?
It is approved in Canada for the following cases:
- Active secondary progressive MS: Here, the symptoms worsen without remission.
- Relapsing-remitting MS: MS that fluctuates between stages of relapse and remission. Symptoms flare up during relapse and reduce during remission.
- Clinically isolated syndrome: It is a condition where you may have symptoms of MS for about 24 hours. In some cases, CIS may turn into MS. However, this may not be true in other cases.
What are some off-label uses of Ponvory?
There is no off-label use of the medicine so far.
Ponvory may be prescribed for other uses; ask your doctor or pharmacist for more information.
Directions for Use Ponvory
- Ponvory is available as a tablet to be taken orally. It can be taken with or without food.
- Take Ponvory at the same time daily.
- Follow the prescription instructions given by your doctor or pharmacist; do not deviate from the same.
- Do not take less or more often than prescribed.
- Do not chew, crush the tablet or spit it. Swallow it as a whole.
- If you miss 1 to 3 days of the dose during the titration period (14-day starter pack), take the missed medication as soon as you remember and continue as planned by taking one tablet a day.
- If you miss more than four days of medication during the titration period (14-day starter pack), you need to immediately call your physician as you may need to restart your treatment with a new 14-day starter pack.
The dosage of Titration Pack contains the following dosage of Ponvory;
|Day 1 and 2||2 mg |
|Day 3 and 4||3 mg |
|Day 5 and 6||4 mg |
|Day 7||5 mg |
|Day 8||6 mg |
|Day 9||7 mg |
|Day 10||8 mg |
|Day 11||9 mg |
|Day 12, 13, and 14||10 mg|
The tablet is available in different dosage strengths: 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, and 20 mg. Your doctor may initially start you with a low dose and gradually increase your dose after 15 days of treatment. The recommended maintenance dose is usually 20 mg once daily starting on Day 15; however, your doctor may decide the best dose for you depending upon the severity of the disease and your other medical conditions.
Benefits and Ingredients of Ponvory
The active ingredient of Ponvory is Ponesimod, which is a sphingosine l-phosphate receptor modulator. It works by decreasing the action of the immune cells that causes damage to the protective covering of the nerves.
What are Ponvory Side Effects?
Like all the medications, Ponvory also has side effects. It is possible that you may experience the following side effects. Inform your physician if these symptoms are severe or if they do not do away:
- Pain in hands or feet
Some of these effects may be serious. If you experience any of them, please get in touch with your physician immediately:
- Worsening shortness of breath
- Loss of appetite
- Abdominal pain
- Dark urine
- Yellowing of skin or eyes
- Sensitivity to light
- Vision problems
- Blindspot in center of your vision
- Slow heartbeat
- Sore throat
- Signs of infection following treatment
- Burning with urination
- Body ache
- Weakness on one side of the body
- Changes in thinking
- Loss of strength
Ponvory may also increase the risk of developing skin cancer. You must inform your doctor immediately if you have any changes in your existing mole, a new dark area on the skin, growths on the skin that may appear shiny, sores that do not heal, or any changes to the skin. You should check your skin and inform your physician of any changes during the treatment with Ponvory immediately.
This is not a complete list of side effects. If you experience severe side effects or symptoms that are persistent, please contact your doctor immediately.
Storage and Disposal of Ponvory
- Store the medicine at room temperature away from moisture and light
- Keep a drying agent in the bottle to protect the medicine from moisture.
- Avoid storing in a bathroom.
- Keep away from the reach of pets and children.
- Do not pour the medicine into a drain or flush it down the toilet unless instructed the same.
Contraindications of Ponvory
Inform your healthcare provider in case of an allergy to Ponvory or any other medication or any of the ingredients in Ponvory. Ask your pharmacist or check the medication guide for a list of the ingredients.
Do not take or inform your doctor if you have or had following conditions;
- If you had any of the following heart-related conditions in the past six months; heart attack, angina (chest pain), mini-stroke, stroke, or heart failure.
- Irregular heart rhythm
- Heart blockage
- Infection that comes and goes away or does not go away
- Sleep apnea (a condition in which a person briefly stops breathing many times during the night)
- Breathing issues
- High blood pressure
- Eye problems
- Skin cancer
- Liver diseases
- QT syndrome (a condition that increases the risk of developing an irregular heartbeat, which may cause sudden fainting or death)
- Recently received vaccine
Ponvory may cause slowing of heartbeat. Inform your physician immediately during the treatment if you experience any of the following; dizziness, chest pain or slow or irregular heartbeat at any time during the treatment.
Besides, inform your doctor if you are pregnant or breastfeeding or planning to be pregnant. You should use birth control to prevent pregnancy during your treatment with Ponvory and at least one week after the treatment. If you become pregnant while you are on treatment with Ponvory or within one week after your final dose of medicine, call your physician immediately as Ponvory may harm your fetus.
Warnings and Precautions of Ponvory
Inform your health worker about other prescription and non-prescription medications that you are taking. Also, inform about vitamins, herbal and nutritional supplements that you are taking or planning to take.
Do not have a vaccine for a month before you begin your treatment with Ponvory. Also, for 1 to 2 weeks after your last dose. Please consult your doctor for vaccination-related concerns.
Inform your physician if you have never taken the chickenpox vaccine or never had chickenpox. Your physician may ask you to undergo a blood test to check if you have had chickenpox. If you never had chickenpox, you may need to take the chickenpox vaccine and wait for four weeks before starting your treatment.
Ponvory may also cause slowing of heartbeat, especially during the first 4 hours of the treatment. You will take your first dose in a hospital or medical facility. You will receive an electrocardiogram before you begin your treatment and again after 4 hours of the first dose. You may need to stay at the medical facility for 4 hours or overnight if you take any medications that may alter your heartbeat.
Interactions with Ponvory
Ponvory may interact with any of the following medications or inform your doctor if you are taking any of the below-mentioned medication:
- Interferon beta
- Glatiramer acetate
- Cancer medications
This may not be a comprehensive list, and other drugs may interact with Ponvory.
Is There A Generic Version of Ponvory?
Ponvory is available as Ponesimod tablets in Canada.
How Is This Medication Different from Others In The Treatment Of Ailment?
Ponvory is available as a once-daily oral medicine, unlike injections or infusion therapy that are commonly used to manage multiple sclerosis.
Who Makes This Drug and What Is Their Manufacturing Record of Success?
Janssen Pharmaceuticals, a global biopharmaceutical company, makes Ponvory. Their main aim is to transform patients’ lives by providing life-changing and life-saving solutions.
Is Ponvory Safe?
Studies have shown that the medicine does not cause adverse events in most individuals. Side effects, when present, are often rare such as dizziness, cough, and pain in extremities. However, if you notice any unusual side effects or last for long, it is best to consult your doctor.