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Clolar (Clofarabine) belongs to the group of cancer-fighting medications known as antineoplastics. It is used to treat pediatric patients (1 to 21 years old) with acute lymphoblastic Leukemia (ALL) that either has been previously treated and has now returned, or is not responding to other medications.
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Clolar (Clofarabine) belongs to the group of cancer-fighting medications known as antineoplastics. It is used to treat pediatric patients (1 to 21 years old) with acute lymphoblastic Leukemia (ALL) that either has been previously treated and has now returned, or is not responding to other medications. Clolar (Clofarabine) causes the death of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction and growth of cells.
Clolar (Clofarabine) may be available under multiple brand names and/or in several different forms. Any specific brand name of Clolar (Clofarabine) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Clolar (Clofarabine) may not be used for all of the conditions discussed here.
Your doctor may have suggested Clolar (Clofarabine) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Clolar (Clofarabine), speak to your doctor. Do not stop taking Clolar (Clofarabine) without consulting your doctor.
Do not give Clolar (Clofarabine) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Clolar (Clofarabine) if their doctor has not prescribed it.
The usual dose of Clolar (Clofarabine) is based on body size. The doctor will calculate the dose based on body surface area, which takes into account a person's height and weight.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Clolar (Clofarabine) is usually injected into a vein through a site on your skin that has been specially prepared for this purpose. Very careful handling of Clolar (Clofarabine) is required. It is always given under the direct supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.
Clolar (Clofarabine) is usually given over 2 hours daily for 5 consecutive days, followed by a recovery period of 2 to 6 weeks, before being repeated.
It is important Clolar (Clofarabine) be given exactly as recommended by your doctor. If you miss an appointment to receive Clolar (Clofarabine), contact your doctor as soon as possible to reschedule your appointment.
Store Clolar (Clofarabine) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Clolar (Clofarabine). If you are concerned about side effects, discuss the risks and benefits of Clolar (Clofarabine) with your doctor.
The following side effects have been reported by at least 1% of people taking Clolar (Clofarabine). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Clolar (Clofarabine).
Each mL of sterile solution for injection contains 1 mg of Clolar (Clofarabine). Nonmedicinal ingredients: sodium chloride and water for injection.
Do not take Clolar (Clofarabine) if you or your child:
There may be an interaction between Clolar (Clofarabine) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Clolar (Clofarabine). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Anemia: Clolar (Clofarabine) may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired or pale skin, contact your doctor as soon as possible.
Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.
Bleeding: Clolar (Clofarabine) may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Dehydration: Clolar (Clofarabine) may cause vomiting and diarrhea, just like other cancer medications. In some circumstances, dehydration may develop. Check with your doctor if you experience decreased urine production, fainting spells, lightheadedness or severe dizziness.
Digestive system problems: Inflammation in the digestive system may occur early in treatment with Clolar (Clofarabine). It is also more likely to occur when Clolar (Clofarabine) is used in combination with other chemotherapy medications. This inflammation can cause severe damage to the digestive system, including, bleeding and infections. If you experience symptoms of digestive system problems, such as fever, abdominal pain, nausea or vomiting, contact your doctor as soon as possible.
Infection: As well as killing cancer cells, Clolar (Clofarabine) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections and areas with lots of people. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.
Kidney function: Reduced kidney function and kidney disease can cause Clolar (Clofarabine) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Clolar (Clofarabine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Clolar (Clofarabine), and whether any special monitoring is needed.
Liver function: Clolar (Clofarabine) may reduce liver function and can cause liver failure. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
If you have liver problems, discuss with your doctor how Clolar (Clofarabine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Clolar (Clofarabine), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Clolar (Clofarabine).
Systemic inflammatory response syndrome: This is a result of the body's natural defenses being over-stimulated, causing a release of cytokines, natural chemicals that work to protect the body. These chemicals cause inflammation throughout the body, which can cause serious harm to the liver, kidney, and other organs, and may be fatal if not treated quickly. Symptoms of this syndrome include rapid heartbeat, rapid breathing, difficulty breathing, very high or very low body temperature and low blood pressure. If you or your child experiences these symptoms, get immediate medical attention.
Tumour lysis syndrome: When large numbers of cancer cells are destroyed quickly, the body has difficulty getting rid of them. This can lead to a temporary, but possibly deadly set of symptoms referred to as tumour lysis syndrome. Your doctor will prescribe some medications to help your body manage this overload, however symptoms are still possible. If you experience or notice any of the following in your child, contact the doctor immediately. Symptoms of tumour lysis syndrome include: rapid breathing, rapid heartbeat, dizziness or lightheadedness, joint pain or decrease in urination.
Pregnancy: There is a possibility of birth defects if Clolar (Clofarabine) is used during pregnancy. Effective birth control should be practiced while using Clolar (Clofarabine) as Clolar (Clofarabine) may harm the baby if used during pregnancy. If you become pregnant while taking Clolar (Clofarabine), contact your doctor immediately.
Breast-feeding: It is not known if Clolar (Clofarabine) passes into breast milk. If you are a breast-feeding mother and are taking Clolar (Clofarabine), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Adults and seniors: The safety and effectiveness of Clolar (Clofarabine) have not been established for individuals over 21 years of age.
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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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