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Ketorolac belongs to the group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used for the short-term treatment (5 to 7 days) of acute pain associated with injuries, dental problems or procedures, and after surgery or giving birth.
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Ketorolac belongs to the group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used for the short-term treatment (5 to 7 days) of acute pain associated with injuries, dental problems or procedures, and after surgery or giving birth. The injectable form of Apo Ketorolac is used for no longer than 2 days to treat moderate-to-severe pain following surgery. Ketorolac reduces a substance in the body that leads to inflammation and pain.
Apo Ketorolac may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Ketorolac may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Ketorolac may not be used for all of the conditions discussed here.
Your doctor may have suggested Apo Ketorolac for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Apo Ketorolac, speak to your doctor. Do not stop taking Apo Ketorolac without consulting your doctor.
Do not give Apo Ketorolac to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Apo Ketorolac if their doctor has not prescribed it.
The usual adult dose of ketorolac when taken by mouth is 10 mg every 4 to 6 hours as required for pain. Taking more than 40 mg daily is not recommended. Take Apo Ketorolac with meals or a snack to reduce stomach upset. After you have taken the medication, remain sitting or standing upright for 15 to 30 minutes to further reduce acid from the stomach irritating the throat.
The medication should be used for a maximum of 5 days for treatment of pain after surgery and for a maximum of 7 days when treating pain due to an injury. The lowest dose required to control the pain should be used. Ketorolac usually starts to work within an hour, but for some people, it may take up to a day to start working. If you don't notice improvement in your pain, contact your doctor. Apo Ketorolac should be used for the shortest time period possible.
Ketorolac is also available for use in the hospital as an injectable medication. The usual recommended dose is 10 mg to 30 mg injected into a muscle for no more than 2 days.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to use Apo Ketorolac exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Apo Ketorolac at room temperature, protect it from light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Apo Ketorolac. If you are concerned about side effects, discuss the risks and benefits of Apo Ketorolac with your doctor.
The following side effects have been reported by at least 1% of people taking Apo Ketorolac. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Ketorolac.
Each round, white, biconvex, film coated tablet engraved "KE" over "10" on one side contains 10 mg of Ketorolac Tromethamine. Nonmedicinal ingredients: magnesium stearate, croscarmellose sodium, lactose, microcrystalline cellulose, hydroxypropyl methylcellulose, titanium dioxide, and polyethylene glycol.
Do not use Apo Ketorolac if you:
There may be an interaction between ketorolac and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Apo Ketorolac. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Ketorolac.
Health Canada has issued new information concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
A previous advisory on non-steroidal anti-inflammatory drugs (NSAIDs) was issued on October 30, 2020.
Allergic reactions: If you have had a reaction to acetylsalicylic acid (ASA) or other NSAIDs (e.g., ibuprofen, Ketoprofen, diclofenac) that included a runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing, you should not take Apo Ketorolac. Get immediate medical attention if you experience symptoms of a severe allergic reaction (e.g., hives, difficulty breathing, wheezing, or swelling of the face, tongue, or throat).
Bladder symptoms: Apo Ketorolac can cause bladder symptoms such as frequent or painful urination and blood in urine. If you develop these symptoms, stop taking Apo Ketorolac and contact your doctor immediately.
Bleeding: Ketorolac may cause the platelets in the blood to not stick together very well. This can make it difficult to stop cuts from bleeding. If you have a condition where your blood does not clot easily, or if you are taking medications to prevent your blood from clotting, discuss with your doctor how Apo Ketorolac may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ketorolac, and whether any special monitoring is needed.
If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Blood pressure: Like other NSAIDs, ketorolac can cause increased blood pressure, which may contribute to other heart conditions. If you have high blood pressure, discuss with your doctor how Apo Ketorolac may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ketorolac, and whether any special monitoring is needed.
Drowsiness and dizziness: Apo Ketorolac can cause drowsiness or dizziness. Do not drive or operate machinery until you are sure that Apo Ketorolac does not affect your ability to do these safely.
Fertility: As with other NSAIDs, Apo Ketorolac may make it more difficult for a couple to conceive if the woman is taking ketorolac. Stopping the medication allows the body's chemistry to return to normal which often resolves this issue.
Heart conditions: Apo Ketorolac can cause fluid retention, which will make symptoms of certain heart conditions worse. If you have heart failure, high blood pressure, or other medical conditions that increase your risk of fluid retention (e.g., kidney problems), discuss with your doctor how Apo Ketorolac may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ketorolac, and whether any special monitoring is needed.
Heart problems: Like other NSAID medications, ketorolac may increase the risk of heart attacks, strokes, and Blood Clots. If you have any risk factors for heart problems, such as high blood pressure, High Cholesterol, Diabetes, peripheral arterial disease, heart failure, or Coronary Artery Disease, discuss with your doctor how Apo Ketorolac may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ketorolac, and whether any special monitoring is needed.
Infection: Apo Ketorolac may mask signs of infection such as fever or muscle aches. If you notice other symptoms of infection (e.g., painful or frequent urination, sore throat, cough), contact your doctor.
Kidney function: Kidney Disease or reduced kidney function may cause Apo Ketorolac to build up in the body, causing side effects. Apo Ketorolac can also affect kidney function. You have a higher risk of developing kidney problems if you are a senior, take diuretics (water pills; e.g., Hydrochlorothiazide, Furosemide), or already have kidney disease, liver disease, or heart failure. Your doctor may monitor your kidney function with blood tests if you take Apo Ketorolac.
Liver function: Apo Ketorolac may affect your liver function or cause liver problems. If you experience symptoms of liver problems (e.g., nausea, vomiting, feeling tired, yellowing of the skin or eyes), contact your doctor immediately. If you have liver problems, discuss with your doctor how Apo Ketorolac may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ketorolac, and whether any special monitoring is needed. People with severely reduced liver function or have active liver disease should not take Apo Ketorolac.
Long-term use: Long-term use of ketorolac (beyond 5 to 7 days for the tablets, or 2 days for the injection) is not recommended, as the risk of side effects increases with the length of treatment.
Potassium levels: Ketorolac may cause high blood potassium levels. If you are a senior, have diabetes or kidney failure, or are taking beta-blockers (e.g., Metoprolol, Atenolol), angiotensin converting enzyme (ACE) inhibitors (e.g., Ramipril, Enalapril), or some diuretics (e.g., triamterene, Amiloride), you are more at risk of high blood potassium. Because extremely high blood potassium levels can contribute to other conditions, such as heart problems, your doctor will monitor your potassium level with blood tests while you are taking Apo Ketorolac.
Ulcers and bleeding in the stomach and intestines: Apo Ketorolac may cause stomach ulcers and bleeding from the stomach. These complications can occur at any time and are sometimes severe.
If you have had a stomach or intestinal ulcer, diverticulosis, Crohn's disease, or ulcerative colitis, discuss with your doctor how Apo Ketorolac may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ketorolac, and whether any special monitoring is needed.
If you experience symptoms of an ulcer or other stomach problems (e.g., stomach or abdominal pain, black stools, bloody or coffee-ground-like vomit, weakness) contact your doctor immediately or get immediate medical attention.
Pregnancy: Apo Ketorolac should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Apo Ketorolac, contact your doctor immediately. It must not be used during the last 3 months of pregnancy as it may cause heart and kidney problems for the developing baby and cause prolonged labour with excessive bleeding during delivery.
Breast-feeding: Apo Ketorolac passes into breast milk. If you are a breast-feeding mother and are taking ketorolac, it may affect your baby. Breast-feeding is not recommended while you are taking ketorolac.
Children: The safety and effectiveness of using Apo Ketorolac have not been established for children less than 18 years of age.
Seniors: Seniors have a higher risk of side effects with Apo Ketorolac. If you are a senior, your doctor will closely monitor you for side effects and may prescribe a lower dose than usually recommended.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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