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Available Form:   Capsule
Manufacturer name:   Merck
Generic name:   progesterone
Strength:   100mg

What is Prometrium?

Prometrium (Progesterone) belongs to the class of medications called progestins. It is used in combination with postmenopausal estrogen replacement therapy (ERT) to prevent the estrogen from thickening the lining of the uterus (a condition known as endometrial hyperplasia).

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Prometrium How to Take

Prometrium (Progesterone) belongs to the class of medications called progestins. It is used in combination with postmenopausal estrogen replacement therapy (ERT) to prevent the estrogen from thickening the lining of the uterus (a condition known as endometrial hyperplasia). This significantly reduces the risk of endometrial cancer. Prometrium (Progesterone) is used for women who have a uterus.

Prometrium (Progesterone) may be available under multiple brand names and/or in several different forms. Any specific brand name of Prometrium (Progesterone) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Prometrium (Progesterone) may not be used for all of the conditions discussed here.

Your doctor may have suggested Prometrium (Progesterone) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Prometrium (Progesterone), speak to your doctor. Do not stop taking Prometrium (Progesterone) without consulting your doctor.

Do not give Prometrium (Progesterone) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Prometrium (Progesterone) if their doctor has not prescribed it.

How should I use Prometrium (Progesterone)?

The recommended dose of Prometrium (Progesterone) is 200 mg daily taken at bedtime for the last 14 days of estrogen treatment per cycle. Women who take high doses of estrogen should receive a Prometrium (Progesterone) dose of 300 mg per day. If the dose is 300 mg daily, 200 mg should be taken at bedtime and 100 mg should be taken 2 hours after breakfast for the last 12 to 14 days of estrogen treatment per cycle.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Prometrium (Progesterone) exactly as prescribed by your doctor. If you are using 200 mg daily and miss a dose of Prometrium (Progesterone) at bedtime (i.e., 2 of the 100 mg capsules), take an extra dose of 100 mg (1 capsule) the following morning and continue taking the rest of the capsules as prescribed by your doctor. If you are taking 300 mg daily and miss a dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Prometrium (Progesterone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

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Prometrium Dosage

The recommended dose of Prometrium (Progesterone) is 200 mg daily taken at bedtime for the last 14 days of estrogen treatment per cycle. Women who take high doses of estrogen should receive a Prometrium (Progesterone) dose of 300 mg per day. If the dose is 300 mg daily, 200 mg should be taken at bedtime and 100 mg should be taken 2 hours after breakfast for the last 12 to 14 days of estrogen treatment per cycle.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Prometrium (Progesterone) exactly as prescribed by your doctor. If you are using 200 mg daily and miss a dose of Prometrium (Progesterone) at bedtime (i.e., 2 of the 100 mg capsules), take an extra dose of 100 mg (1 capsule) the following morning and continue taking the rest of the capsules as prescribed by your doctor. If you are taking 300 mg daily and miss a dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Prometrium (Progesterone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Prometrium Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Prometrium (Progesterone). If you are concerned about side effects, discuss the risks and benefits of Prometrium (Progesterone) with your doctor.

The following side effects have been reported by at least 1% of people taking Prometrium (Progesterone). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain or cramping
  • Acne
  • breast pain or tenderness
  • brown spots on exposed skin, possibly long-lasting
  • change of sexual desire
  • difficulty concentrating
  • difficulty wearing contact lenses
  • dizziness
  • drowsiness
  • headache
  • hot flashes
  • short term joint or muscle pain
  • loss or gain of body, facial, or scalp hair
  • mood changes
  • nervousness
  • premenstrual syndrome (PMS)
  • swelling of face, ankles, or feet
  • weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • allergic reaction (e.g., Hives, skin rash, itchiness)
  • breast lump
  • changes in vaginal bleeding, such as:
    • heavier vaginal bleeding between regular monthly periods
    • increased amounts of menstrual bleeding occurring at regular monthly periods
    • lighter vaginal bleeding between menstrual periods
    • stopping of menstrual periods
  • confusion
  • fast or pounding heartbeat
  • increased blood pressure
  • worsened menstrual cramps
  • painful urination
  • pain during sexual intercourse
  • signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • signs of liver problems (e.g., nausea, vomiting, Diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • vaginal itching or discharge
  • worsening Headaches or migraines

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of a blood clot in blood vessels, such as sudden vision change or dizziness, chest pain, pain and swelling in one leg muscle
  • signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
  • signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Prometrium (Progesterone).

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Prometrium Available Form

Each capsule contains 100 mg of micronized Prometrium (Progesterone). Nonmedicinal ingredients: sunflower oil, gelatin, glycerin, soya lecithin, and titanium dioxide.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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