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August 8, 2022

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August 2, 2022
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Available Form:
capsule
Manufacturer name:
merck
Generic name:
progesterone
Strength:
100MG
Prometrium (Progesterone) belongs to the class of medications called progestins. It is used in combination with postmenopausal estrogen replacement therapy (ERT) to prevent the estrogen from thickening the lining of the uterus (a condition known as endometrial hyperplasia).
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Prometrium (Progesterone) belongs to the class of medications called progestins. It is used in combination with postmenopausal estrogen replacement therapy (ERT) to prevent the estrogen from thickening the lining of the uterus (a condition known as endometrial hyperplasia). This significantly reduces the risk of endometrial cancer. Prometrium (Progesterone) is used for women who have a uterus.
Prometrium (Progesterone) may be available under multiple brand names and/or in several different forms. Any specific brand name of Prometrium (Progesterone) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Prometrium (Progesterone) may not be used for all of the conditions discussed here.
Your doctor may have suggested Prometrium (Progesterone) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Prometrium (Progesterone), speak to your doctor. Do not stop taking Prometrium (Progesterone) without consulting your doctor.
Do not give Prometrium (Progesterone) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Prometrium (Progesterone) if their doctor has not prescribed it.
The recommended dose of Prometrium (Progesterone) is 200 mg daily taken at bedtime for the last 14 days of estrogen treatment per cycle. Women who take high doses of estrogen should receive a Prometrium (Progesterone) dose of 300 mg per day. If the dose is 300 mg daily, 200 mg should be taken at bedtime and 100 mg should be taken 2 hours after breakfast for the last 12 to 14 days of estrogen treatment per cycle.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Prometrium (Progesterone) exactly as prescribed by your doctor. If you are using 200 mg daily and miss a dose of Prometrium (Progesterone) at bedtime (i.e., 2 of the 100 mg capsules), take an extra dose of 100 mg (1 capsule) the following morning and continue taking the rest of the capsules as prescribed by your doctor. If you are taking 300 mg daily and miss a dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Prometrium (Progesterone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
The recommended dose of Prometrium (Progesterone) is 200 mg daily taken at bedtime for the last 14 days of estrogen treatment per cycle. Women who take high doses of estrogen should receive a Prometrium (Progesterone) dose of 300 mg per day. If the dose is 300 mg daily, 200 mg should be taken at bedtime and 100 mg should be taken 2 hours after breakfast for the last 12 to 14 days of estrogen treatment per cycle.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Prometrium (Progesterone) exactly as prescribed by your doctor. If you are using 200 mg daily and miss a dose of Prometrium (Progesterone) at bedtime (i.e., 2 of the 100 mg capsules), take an extra dose of 100 mg (1 capsule) the following morning and continue taking the rest of the capsules as prescribed by your doctor. If you are taking 300 mg daily and miss a dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Prometrium (Progesterone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Prometrium (Progesterone). If you are concerned about side effects, discuss the risks and benefits of Prometrium (Progesterone) with your doctor.
The following side effects have been reported by at least 1% of people taking Prometrium (Progesterone). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Prometrium (Progesterone).
Each capsule contains 100 mg of micronized Prometrium (Progesterone). Nonmedicinal ingredients: sunflower oil, gelatin, glycerin, soya lecithin, and titanium dioxide.
Do not take Prometrium (Progesterone) if you:
There may be an interaction between Prometrium (Progesterone) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Prometrium (Progesterone). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Prometrium (Progesterone).
Important information about estrogen:
Breast and Ovarian Cancer: Several studies have shown an association between a modest increase in the risk of developing Breast Cancer or ovarian cancer and the use of hormone replacement therapy during Menopause when taken over the long term. Ask your doctor which cancer screening tests you may need and how to perform breast self-examination. Women who have breast nodules, fibrocystic disease, abnormal mammograms, or a strong family history of breast cancer should be closely monitored by their doctor.
Dementia: Women over the age of 65 receiving combined hormone replacement therapy (estrogen and progestin) may be at increased risk of developing dementia (loss of memory and intellectual function). If you are over 65, talk to your doctor about whether you should be tested for dementia.
Depression: Hormones, such as Prometrium (Progesterone), have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Prometrium (Progesterone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Prometrium (Progesterone), and whether any special monitoring is needed.
If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking Prometrium (Progesterone) contact your doctor as soon as possible.
Diabetes: As with other hormone replacement medications, Prometrium (Progesterone) may cause an increase in blood sugar levels and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Prometrium (Progesterone).
If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Prometrium (Progesterone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Prometrium (Progesterone), and whether any special monitoring is needed.
Follow-up examinations: It is important to have a follow-up examination 3 to 6 months after starting Prometrium (Progesterone) to assess your response to treatment. Examinations should be done at least once a year after the first one.
Heart Disease: Several studies have demonstrated that the use of estrogen and progestins to treat menopausal symptoms is related to an increased risk of heart disease, blood clots, and stroke. If you have risk factors for heart disease or stroke, discuss with your doctor how Prometrium (Progesterone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Prometrium (Progesterone), and whether any special monitoring is needed.
Occupational hazards: Temporary and occasional drowsiness or dizziness may occur for some people 1 to 4 hours after taking Prometrium (Progesterone), particularly if it is taken with food. If this occurs, avoid activities requiring concentration, good coordination, or reflex action such as driving or operating machinery. In most cases, these problems can be prevented by taking the capsules at the recommended times. The 200 mg dosage should be taken at bedtime. The 300 mg dosage should be divided into two doses: 100 mg 2 hours after breakfast and 200 mg at bedtime.
Vaginal bleeding: Prometrium (Progesterone) can cause changes to your normal pattern of vaginal bleeding. If you experience menstrual bleeding that lasts longer or heavier than usual, contact your doctor.
Pregnancy: Do not take Prometrium (Progesterone) during pregnancy. If you become pregnant while taking Prometrium (Progesterone), contact your doctor immediately.
Breast-feeding: Prometrium (Progesterone) passes into breast milk. If you are a breast-feeding mother and are taking Prometrium (Progesterone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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