Tramacet

Prescription required

Tramacet

Available Form:  

TABLET

Manufacturer name:  

Janssen

Strength:  

37.5+325MG

What is Tramacet?

This combination product contains two medications: Tramadol and Acetaminophen. Tramadol belongs to a group of medications called opioid analgesics and acetaminophen belongs to a group of medications called analgesics.

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Tramacet How to Take

This combination product contains two medications: Tramadol and Acetaminophen. Tramadol belongs to a group of medications called opioid analgesics and acetaminophen belongs to a group of medications called analgesics. This combination medication is used to manage moderate to moderately severe pain in adults, for whom other pain relievers have not been effective. It decreases pain by working on the central nervous system.

Tramacet may be available under multiple brand names and/or in several different forms. Any specific brand name of Tramacet may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Tramacet may not be used for all of the conditions discussed here.

Your doctor may have suggested Tramacet for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Tramacet, speak to your doctor. Do not stop taking Tramacet without consulting your doctor.

Do not give Tramacet to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Tramacet if their doctor has not prescribed it.

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Tramacet Dosage

The usual recommended dose of tramadol - acetaminophen is 1 or 2 tablets every 4 to 6 hours as needed for pain relief, up to a maximum of 8 tablets daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The tablets can be taken with or without food.

Do not stop taking Tramacet without talking with your doctor. If Tramacet is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, Diarrhea, or hallucinations. If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects.

It is important to take Tramacet exactly as prescribed by your doctor. If your doctor has told you to take Tramacet on a regular basis and you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Tramacet at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Tramacet Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Tramacet. If you are concerned about side effects, discuss the risks and benefits of Tramacet with your doctor.

The following side effects have been reported by at least 1% of people taking Tramacet. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • Constipation
  • decreased appetite
  • decreased interest in sexual activity
  • decreased sexual ability
  • dizziness
  • drowsiness
  • Dry Mouth
  • fainting
  • headache
  • itching
  • nausea
  • sweating
  • trouble sleeping
  • vision problems
  • vomiting
  • weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • fast, slow, or irregular heartbeat
  • Low Blood Pressure (e.g., dizziness, fainting, light-headedness)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)
  • symptoms of low sodium in the blood (e.g., tiredness, weakness, confusion, achy, stiff or uncoordinated muscles)
  • withdrawal symptoms (e.g., nausea, vomiting, diarrhea, anxiety, shivering, cold and clammy skin, body aches, loss of appetite, sweating)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • seizures
  • signs of taking too much medication, e.g.,:
    • shallow, rapid breathing
    • severe drowsiness
    • decreased coordination
    • seizures
    • unconsciousness
  • signs of a Anaphylaxis (severe allergic reaction), e.g.:
    • difficulty breathing
    • Hives
    • swelling of the lips, mouth, throat, or tongue
  • signs of a severe skin reaction, e.g.:
    • high Fever
    • painful blisters on the skin, mouth, or eyes
    • rash
    • skin peeling off
    • sores
  • slow or weak breathing
  • symptoms of a bowel blockage (e.g., abdominal pain, severe constipation, nausea)
  • symptoms of serotonin syndrome (e.g., confusion, fast heartbeat, hallucinations, high blood pressure, restlessness, shaking, shivering, sudden jerking of muscles, sweating)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tramacet.

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Tramacet Available Form

37.5 mg/325 mg
Each light yellow, film-coated, capsule-shaped tablet, marked "J-C" on one side and "T/P" on the other, contains 37.5 mg of tramadol and 325 mg of acetaminophen. Nonmedicinal ingredients: carnauba wax, hypromellose, magnesium stearate, polyethylene glycol, polysorbate 80, powdered cellulose, pregelatinized starch, sodium starch glycolate, starch, titanium dioxide, and yellow iron oxide.

Tramacet Contraindications

Do not take Tramacet if you:

  • are allergic to tramadol, acetaminophen, or any ingredients of the medication
  • are allergic to other opioid medications (e.g., Codeine, Morphine)
  • are experiencing acute Alcoholism or delirium tremens
  • are experiencing acute Asthma or other obstructive airway disease
  • are experiencing acute respiratory Depression
  • have mild pain, which can be treated with other pain medications
  • have or may have an abdominal condition that may require surgery (Appendicitis, pancreatitis)
  • are intoxicated with alcohol or other medications such as hypnotics, other opioids such as codeine or morphine, or psychotropic medications (i.e., medications for mental health conditions)
  • are pregnant, in labour, delivering a baby, or breast-feeding
  • are taking or have taken MAO inhibitors (e.g., Phenelzine, Tranylcypromine, Moclobemide) within the last 14 days
  • have a blockage of the gastrointestinal tract, particularly paralytic ileus
  • have a convulsive (seizure) disorder
  • have a head injury, a brain tumour, or increased pressure inside the head or spinal cord
  • have severe central nervous system (CNS) depression (e.g., slowed nervous system)
  • have severely decreased kidney function
  • have severely decreased liver function

Do not give Tramacet to children less than 12 years old.

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Tramacet Precautions

There may be an interaction between tramadol - acetaminophen and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Tramacet. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Tramacet Warnings

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Tramacet.

Abdominal conditions: Tramadol - acetaminophen may make the diagnosis of abdominal conditions more difficult or it may worsen these conditions. If you have an abdominal condition such as inflammatory or obstructive bowel disease, acute cholecystitis, or pancreatitis, discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed.

Accidental use: When tramadol-acetaminophen is used by anyone other than the person for whom it was prescribed, the effects of the medication may be fatal. Keep Tramacet out of sight and reach of children.

Acetaminophen overuse: Although acetaminophen is usually considered a safe medication, overuse of acetaminophen can cause liver damage, including liver failure causing death or requiring a liver transplant. It is important that you do not take more of tramadol - acetaminophen than prescribed by your doctor. Acetaminophen can be found in many medications that are available without a prescription. Read the labels carefully to make sure you are not taking more than the recommended adult dose of acetaminophen when you consider the different medications that you are taking. If you have questions about the amount of acetaminophen you are taking, contact your pharmacist or doctor.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Alcohol use: Consuming alcohol while taking tramadol – acetaminophen increases the risk of dangerous side effects of the medication, including breathing problems, seizures, and drowsiness. It is recommended that you avoid drinking alcohol while you are using Tramacet for pain.

Breathing: Tramadol - acetaminophen can suppress breathing. If you have asthma, COPD (Chronic Obstructive Pulmonary Disease), or are otherwise at risk for breathing problems, discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed.

Dependence and withdrawal: Tramadol can cause physical dependence, psychological dependence, and addiction. People with a history of past or current Substance Use Problems may be at greater risk of developing abuse or addiction while taking Tramacet. If Tramacet is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shaking, pain, nausea, tremors, diarrhea, and hallucinations. If you have been taking Tramacet for a while, it should be stopped gradually as directed by your doctor. Do not stop taking Tramacet without talking to your doctor or pharmacist.

Drowsiness/reduced alertness: Tramacet may cause drowsiness or affect the mental abilities needed to perform hazardous tasks. Combining Tramacet with alcohol or other medications that cause drowsiness (e.g., antidepressants, sleeping pills, anxiety medications) should be avoided, since additional drowsiness and dizziness can occur and be dangerous and possibly fatal. Do not drive, operate machinery, or perform other hazardous tasks until you have determined how Tramacet affects you.

Head injury: People with head injuries or increased pressure in the head may have a higher risk of experiencing side effects (breathing problems) or worsening of their condition while taking Tramacet. If you have had a recent head injury, discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed.

Heart rhythm: Tramadol can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death.  Although this is generally a concern only when you are taking high doses of tramadol or you take too much at one time, if you are at risk for heart rhythm problems (e.g., people with heart failure, Angina, low potassium or magnesium levels), discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed.

Kidney function: The kidneys are partially responsible for removing tramadol from the body. Kidney Disease or decreased kidney function may cause Tramacet to build up in the body, causing side effects. If you have kidney disease or reduced kidney function, discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed. Tramacet is not recommended for people with severely decreased kidney function.

Liver function: The liver is partially responsible for removing tramadol and acetaminophen from the body. Liver disease or decreased liver function may cause Tramacet to build up in the body, causing side effects. If you have liver disease or reduced liver function, discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed. Tramacet should not be used by people who are experiencing severe liver failure.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, blood pressure drops too low after taking tramadol – acetaminophen. This is more likely to occur for those who take water pills, have a salt-restricted diet, are on dialysis, are suffering from diarrhea or vomiting, or have been sweating excessively and not drinking enough liquids. Get up slowly when rising from a sitting or lying down position. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Seizures: Tramadol may cause seizures, especially when higher doses are used or when taken with other medications such as:

The risk of seizures is also higher for people with a history of seizures, or who are at risk of seizures (e.g., people with head trauma). If you have a history of seizures, or are at risk of seizures, discuss with your doctor how Tramacet may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tramacet, and whether any special monitoring is needed.

Serotonin syndrome: Severe reactions are possible when tramadol is combined with medications used to treat depression. The combination of tramadol and MAO inhibitors must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible.

Surgery: Tramadol may interact with medications used during surgery. If you are scheduled for surgery, let your doctor know that you are taking Tramacet.

Pregnancy: Taking Tramacet during pregnancy may affect the developing baby, causing dangerous withdrawal symptoms when the baby is born. Tramacet should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Tramacet, contact your doctor immediately.

Breast-feeding: Tramacet passes into breast milk. If you are a breast-feeding mother and are taking tramadol - acetaminophen, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Tramacet have not been established for children. Tramacet should not be used by people under 18 years of age.

Seniors: Seniors may be more likely to experience side effects from Tramacet. Lower doses may be required.

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References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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