Apo Imatinib

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Available Form:  

TABLET

Manufacturer name:  

Apotex

Generic name:  

IMATINIB-MESYLATE

Strength:  

100MG, 400MG

What is Apo Imatinib?

Imatinib belongs to a family of medications called protein tyrosine kinase inhibitors. It is used to treat adults and children who have been newly diagnosed with Philadelphia chromosome positive chronic myeloid Leukemia (Ph+ CML) in chronic phase.

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Apo Imatinib Price and Cost Calculator

IMATINIB 400MG

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Apo Imatinib Indication

Imatinib belongs to a family of medications called protein tyrosine kinase inhibitors. It is used to treat adults and children who have been newly diagnosed with Philadelphia chromosome positive chronic myeloid Leukemia (Ph+ CML) in chronic phase. It works by affecting enzymes that play a role in certain cancer cells.

It is also used to treat adults with Ph+ CML in blast crisis (sudden attack), accelerated phase (fast growth), or chronic phase (long-term illness) after the failure of interferon-alpha therapy.

It is used to treat adults who have been newly diagnosed with certain types of acute lymphoblastic leukemia (Philadelphia-positive – Ph+ ALL). It is also used to treat Ph+ ALL that have not responded to other medications. Imatinib is also used to treat dermatofibrosarcoma protuberans (DFSP), a cancer where tissue under the skin grows out of control, when it cannot be removed by surgery or it is spreading to other parts of the body.

Other types of cancers can also be treated with imatinib. Imatinib may be used to treat certain types of gastrointestinal stromal tumours (GIST), a cancer of the stomach and bowels. Imatinib may also be used to treat some types of myelodysplastic/myeloproliferative diseases (MDS/MPD), aggressive systemic mastocytosis (ASM), hypereosinophilic syndrome (HES), and chronic eosinophilic leukemia (CEL). In these conditions, different types of blood cells start growing out of control.

Apo Imatinib (Imatinib-mesylate) may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Imatinib (Imatinib-mesylate) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Imatinib (Imatinib-mesylate) may not be used for all of the conditions discussed here.

Your doctor may have suggested Apo Imatinib (Imatinib-mesylate) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Apo Imatinib (Imatinib-mesylate), speak to your doctor. Do not stop taking Apo Imatinib (Imatinib-mesylate) without consulting your doctor.

Do not give Apo Imatinib (Imatinib-mesylate) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Apo Imatinib (Imatinib-mesylate) if their doctor has not prescribed it.

Apo Imatinib Dosage

Treatment with imatinib should be started under the direct supervision of a physician experienced in the treatment of the conditions for which Apo Imatinib (Imatinib-mesylate) is being used.

Doses for children are based on body size and will be calculated by your child's doctor.

For newly diagnosed chronic myeloid leukemia (CML) or chronic phase CML, the usual adult dose of imatinib is 400 mg daily. The usual adult dose in accelerated phase or blast crisis CML is 600 mg daily. Depending on how you respond to the treatment and on the side effects you experience, you doctor may increase your dose to 800 mg daily.

For cancerous gastrointestinal stromal tumours (GIST), the usual adult dose ranges from 400 mg to 600 mg daily. Dose adjustments may be required depending on your response and on the side effects you experience. The usual dose for adults at intermediate to high risk of relapse of GIST is 400 mg taken once daily.

For Ph+ ALL, the usual adult dose is 600 mg daily.

For MDS/MPD in adult patients, the starting dose is 400 mg daily.

For some types of ASM, HES, or CEL, the starting dose is 100 mg daily. Depending on how you respond to the treatment and on the side effects you experience, you doctor may increase your dose to 400 mg daily.

For DFSP in adult patients, imatinib is taken as 800 mg daily. Doses of 800 mg should be taken as 400 mg twice a day, in the morning and evening.

Imatinib should be taken by mouth, with a meal and a large glass of water. Avoid drinking grapefruit juice while you are taking imatinib. Swallow the tablets whole.

If you are not able to swallow the tablet(s) whole, the tablet(s) may be dissolved in a glass of water or apple juice. Stir with a spoon to completely disintegrate. This liquid must be swallowed immediately. Rinse the glass with the same fluid and drink this as well.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Apo Imatinib (Imatinib-mesylate) be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you vomit after taking a dose, do not take a replacement dose. Take your next dose at the usual time.

Store Apo Imatinib (Imatinib-mesylate) at room temperature, in its original package, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Apo Imatinib Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Apo Imatinib (Imatinib-mesylate). If you are concerned about side effects, discuss the risks and benefits of Apo Imatinib (Imatinib-mesylate) with your doctor.

The following side effects have been reported by at least 1% of people taking Apo Imatinib (Imatinib-mesylate). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain or bloating
  • blurred vision
  • bone pain
  • changes in appetite
  • Constipation
  • cough
  • Diarrhea
  • difficulty sleeping
  • dizziness
  • Dry Mouth
  • fatigue
  • gas (flatulence)
  • headache
  • increased muscle tension
  • increased skin sensitivity to the sun
  • increased tear production
  • indigestion or heartburn
  • itchy, dry skin
  • itchy, dry eyes
  • joint pain
  • joint swelling
  • loss of appetite
  • mouth sores
  • muscle pain
  • muscle spasms and cramps
  • nausea
  • night sweats
  • numbness or tingling of the hands of feet
  • skin rash
  • slowed growth in children and adolescents
  • taste disturbance
  • unusual hair loss or thinning
  • vomiting
  • weakness
  • weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • Cellulitis (red, hot, painful, swollen areas under the skin)
  • changed or unusual menstrual bleeding
  • difficult or painful breathing
  • eye infection
  • fainting
  • Fever
  • hearing problems
  • numb or cold toes and fingers
  • pain or difficulty walking
  • red or swollen palms of the hands or soles of the feet
  • severe headache
  • signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
  • signs of electrolyte imbalance (e.g., muscle pain or cramps, weakness, irregular heart beat)
  • signs of fluid retention (e.g., rapid weight gain and swelling)
  • signs of infection (e.g., fever, severe chills, sore throat, mouth ulcers)
  • signs of inflammatory bowel disease (e.g., nausea, vomiting, diarrhea, stomach pain, fever)
  • signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
  • signs of liver damage (e.g., yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, or nausea and vomiting)
  • signs of Low Blood Pressure (e.g., dizziness, lightheadedness)
  • signs of muscle damage (e.g., muscle pain, tenderness or weakness, or brown or discoloured urine) - especially if you also have a fever or a general feeling of being unwell
  • symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, swelling of lips, Hives, difficulty breathing, nausea, vomiting, swelling face and throat)
  • chest pain
  • irregular or pounding heartbeat
  • seizures
  • severe abdominal pain
  • severe painful swelling of an extremity (i.e., arms or legs)
  • severe skin reactions on a large area of the body or on the lips (e.g., ulcers, blisters, pain, redness, severe rash, skin peeling)
  • shortness of breath
  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, coughing up blood, vomiting blood or material that looks like coffee grounds)
  • signs of fluid in the lungs (e.g., cough, chest pain, difficulty breathing, coughing up blood)
  • signs of Heart Attack (e.g., sudden chest pain or pain radiating to the back, down the arm, or in the jaw; sensation of fullness of the chest; nausea; vomiting; sweating; anxiety)
  • signs of Stroke due to bleeding into the brain (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
  • symptoms of heart failure (e.g., leg swelling, chest pain, or shortness of breath)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Imatinib (Imatinib-mesylate).

Apo Imatinib Available form

100 mg
Each brownish-orange, slightly biconvex, round, film-coated tablet, engraved "IMA" over score "100" on one side and "APO" on the other, contains 100 mg of imatinib.Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, ferric oxide red, and ferric oxide yellow.

400 mg
Each brownish-orange, capsule-shaped, biconvex film-coated tablet, engraved "IMA" score line "400" on one side and "APO" on the other, contains 400 mg of imatinib. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, ferric oxide red, and ferric oxide yellow.

Apo Imatinib Contraindications

Do not take Apo Imatinib (Imatinib-mesylate) if you are allergic to imatinib or any ingredients of the medication.

Apo Imatinib (Imatinib-mesylate) should not be used except under direct supervision by an experienced physician.

Apo Imatinib Precautions

There may be an interaction between imatinib and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Apo Imatinib (Imatinib-mesylate). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Apo Imatinib Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Imatinib (Imatinib-mesylate).

Anemia: Imatinib may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.

Bleeding: Imatinib may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.

Drowsiness/reduced alertness: Apo Imatinib (Imatinib-mesylate) is not expected to make you drowsy and impair your ability to drive or use machinery. However, it may make some people feel weak. Do not drive or use machinery until you know how Apo Imatinib (Imatinib-mesylate) affects you.

Fluid retention: Apo Imatinib (Imatinib-mesylate) can cause serious fluid retention. If you experience unexpected rapid weight gain or swelling in your feet, ankles, lower legs, or hands, contact your doctor immediately. Your doctor will weigh and monitor you regularly for signs of fluid retention while you are taking Apo Imatinib (Imatinib-mesylate).

Grapefruit juice: Grapefruit juice affects how imatinib is removed from the body and may cause too much of the medication to build up in the body. Do not drink grapefruit juice while taking Apo Imatinib (Imatinib-mesylate).

Heart problems and heart failure: Rarely, heart problems including heart failure, have been reported with the use of imatinib. If you are at risk for heart problems such as heart failure (e.g., people with high blood pressure, Diabetes, and Coronary Artery Disease), discuss with your doctor how Apo Imatinib (Imatinib-mesylate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Imatinib (Imatinib-mesylate), and whether any special monitoring is needed. Contact your doctor immediately if you have symptoms of heart failure such as leg swelling, chest pain, or shortness of breath.

Hepatitis B: People who have hepatitis B or have had hepatitis B infection are at risk of the infection returning when they are taking imatinib or after stopping the medication. If you have a history of hepatitis B infection, discuss with your doctor how Apo Imatinib (Imatinib-mesylate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Imatinib (Imatinib-mesylate), and whether any special monitoring is needed.

Infection: As well as killing cancer cells, imatinib can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Decreased kidney function or Kidney Disease may cause Apo Imatinib (Imatinib-mesylate) to build up in the body, causing side effects. If you have kidney problems, discuss with your doctor how Apo Imatinib (Imatinib-mesylate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Imatinib (Imatinib-mesylate), and whether any special monitoring is needed.

Liver function: Imatinib may affect liver function. If you have liver problems, discuss with your doctor how Apo Imatinib (Imatinib-mesylate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Imatinib (Imatinib-mesylate), and whether any special monitoring is needed. Your doctor may want to test your liver function with blood tests regularly while you are taking Apo Imatinib (Imatinib-mesylate).

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Male fertility: There is evidence that men who take imatinib may experience decreased fertility. If this is a concern, speak to your doctor about fertility preservation.

Muscle effects: In rare cases, serious muscle damage has been associated with the use of Apo Imatinib (Imatinib-mesylate). Report any unexplained muscle pain, tenderness, weakness or cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or fever.

Stomach problems: Imatinib may cause stomach irritation or bleeding. To reduce stomach irritation, take Apo Imatinib (Imatinib-mesylate) with food and a large glass of water. If you experience signs of stomach bleeding (e.g., severe stomach pain, black stools, vomiting blood, dizziness), get immediate medical attention.

Thyroid: If you have Hypothyroidism due to removal of thyroid gland, you may need closer monitoring of your thyroid levels. Let your doctor know if you are experiencing unusual tiredness, weight gain, hair loss, unusually dry skin, mood changes, and intolerance to cold temperatures.

Tumour lysis syndrome: Imatinib, like many other cancer medications, causes many cancer cells to be suddenly killed when treatment is first started. This can overwhelm the body with waste products from the cells. As a result, the body may not be able to keep up with getting rid of all the waste. When this happens, you may experience nausea and shortness of breath, and notice cloudy urine or joint pain. This is called tumour lysis syndrome. Your doctor may prescribe some medications to help your body get rid of the waste products. Make sure you understand how to use these medications and report any of these signs or symptoms to your doctor immediately.

Pregnancy: Apo Imatinib (Imatinib-mesylate) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Apo Imatinib (Imatinib-mesylate), contact your doctor immediately. Women of childbearing age who are taking imatinib should use an effective method of birth control during treatment.

Breast-feeding: Apo Imatinib (Imatinib-mesylate) passes into breast milk. If you are a breast-feeding mother and are taking imatinib, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Apo Imatinib (Imatinib-mesylate) have not been established for children less than 2 years of age. Growth may be slowed in children and adolescents that take Apo Imatinib (Imatinib-mesylate).

Seniors: Seniors have a greater risk of fluid retention than younger patients. Contact your doctor if you experience a sudden increase in weight or swelling of the ankles, lower legs, or hands. Your doctor will weigh and monitor you closely.

Apo Imatinib frequently asked questions

How To Buy Apo Imatinib Online?

You can buy Apo Imatinib online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Apo Imatinib?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Apo Imatinib in Canada?

Shipping cost for Apo Imatinib to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Apo Imatinib delivered to my home?

You could get Apo Imatinib delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Apo Imatinib in Canada for free?

You can get Apo Imatinib for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Apo Imatinib for free.

Can I consult a doctor online to get Apo Imatinib?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Apo Imatinib.

Can I buy Apo Imatinib without a prescription?

You need a valid prescription to buy Apo Imatinib from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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