Diprivan

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who receives Diprivan (Propofol). If you are concerned about side effects, discuss the risks and benefits of Diprivan (Propofol) with your doctor.

The following side effects have been reported by at least 1% of people receiving Diprivan (Propofol). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• decreased or increased heart rate
• dizziness
• flushing
• headache
• heat or pain at the injection site
• irregular heartbeat
• Low Blood Pressure
• nausea
• rash
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• difficulty breathing
• signs of muscle damage (e.g., unexplained muscle pain, tenderness, or weakness or brown or discoloured urine)
• muscle spasms

Stop using the medication and seek immediate medical attention if any of the following occur:

• seizures
• symptoms of a Heart Attack (e.g., chest pain, difficulty breathing, pain down left arm)
• symptoms of an allergic reaction (e.g., difficulty breathing, sweating, swelling of the face or throat, Hives)
• symptoms of low blood sugar (e.g., dizziness, confusion, weakness, sweating)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Diprivan (Propofol).

Each mL of white, oil in water emulsion contains 10 mg Diprivan (Propofol) for IV administration. Nonmedicinal ingredients: soybean oil, glycerol, egg phosphatide, disodium edetate, and water for injection with sodium hydroxide to adjust pH.

Do not use Diprivan (Propofol) if you:

• are allergic to Diprivan (Propofol) or any ingredients of Diprivan (Propofol)
• are 18 years of age or younger receiving intensive care
• have any contraindications to sedation or general anaesthesia

There may be an interaction between Diprivan (Propofol) and any of the following:

• alcohol
• Aldesleukin
• Aliskiren
• alpha-agonists (e.g., Clonidine, methyldopa)
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
• angiotensin receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
• amifostine
• antiarrhythmics (e.g., Amiodarone, Disopyramide, Dronedarone, procainamide, quinidine)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• azelastine
• barbiturates (e.g., butalbital, pentobarbital, Phenobarbital)
• benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• brimonidine
• Buprenorphine
• Buspirone
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• cannabis
• chloral hydrate
• diazoxide
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• Duloxetine
• efavirenz
• Entacapone
• Flibanserin
• general anaesthetics (medications to put you to sleep for surgery)
• Guanfacine
• Hydralazine
• levodopa
• Lomitapide
• magnesium sulfate
• mifepristone
• Minoxidil
• Mirtazapine
• muscle relaxants (e.g., Baclofen, Cyclobenzaprine, methocarbamol, orphenadrine)
• Nabilone
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• Nilotinib
• nitrates (e.g., Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
• Obinutuzumab
• Pentoxifylline
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• Pramipexole
• quinine
• rifampin
• Riociguat
• Ropinirole
• Rotigotine
• scopolamine
• seizure medications (e.g., Carbamazepine, Clobazam, Levetiracetam, phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• sodium oxybate
• Tapentadol
• Tetrabenazine
• thalidomide
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Clomipramine, Desipramine, Imipramine)
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Diprivan (Propofol). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Diprivan (Propofol).

Drowsiness/reduced alertness: Diprivan (Propofol) will cause reduced alertness and cause a person to be drowsy even after they have awakened. If you have received Diprivan (Propofol) as part of an outpatient procedure, you should not drive or operate machinery until the effects of Diprivan (Propofol) have completely passed.

Heart disease: Diprivan (Propofol) can caused decreased heart rate or blood pressure. If you have heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diprivan (Propofol), and whether any special monitoring is needed.

Impaired fat (lipid) metabolism: If you have impaired lipid metabolism (e.g., high lipid levels associated with Diabetes, pancreatitis), discuss with your doctor how Diprivan (Propofol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diprivan (Propofol), and whether any special monitoring is needed.

Impaired kidney and liver function: The safety and effectiveness of using this medication if you have impaired kidney and liver function have not been established.

Seizures: If you have seizures or a history of seizures, discuss with your doctor how Diprivan (Propofol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: There is evidence that a baby who is exposed to Diprivan (Propofol) before birth may experience impaired brain development. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you are or may be pregnant and require Diprivan (Propofol), contact your doctor immediately.

Breast-feeding: Diprivan (Propofol) passes into breast milk. If you are a breast-feeding mother and are taking Diprivan (Propofol), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of this medication have not been established for children less than 3 years of age. There is evidence that the use of Diprivan (Propofol) to treat young children may cause decreased or impaired brain development. Diprivan (Propofol) may be used as part of anesthesia for children 3 years of age and older. It should not be used for children under the age of 18 as sedation in intensive care or conscious sedation.

Seniors: Seniors may be much more likely to experience side effects of Diprivan (Propofol) and may require lower doses.