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Available Form:   24-Hour Release Tablet
Manufacturer name:   Apotex
Strength:   400mg

What is Apo Nevirapine ER?

Nevirapine belongs to the class of antiretroviral medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs).  It is used in combination with other antiretroviral medications to treat the infection caused by the human immunodeficiency virus (HIV).

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Apo Nevirapine ER frequently asked questions

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Apo Nevirapine ER in Canada?

Shipping cost for Apo Nevirapine ER to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Apo Nevirapine ER delivered to my home?

You could get Apo Nevirapine ER delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Apo Nevirapine ER in Canada for free?

You can get Apo Nevirapine ER for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Apo Nevirapine ER for free.

Apo Nevirapine ER How to Take

Nevirapine belongs to the class of antiretroviral medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It is used in combination with other antiretroviral medications to treat the infection caused by the human immunodeficiency virus (HIV).

HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). HIV infection destroys CD4 (T) cells, which are important to the immune system. The immune system helps fight infections.

Reverse transcriptase is a part of HIV required to infect cells and make more virus. Nevirapine prevents reverse transcriptase from working properly.

Nevirapine does not cure AIDS and does not prevent it from being spread to others. It helps to slow down further growth or reproduction of HIV when used in combination with other medications. It also seems to slow down the destruction of the immune system. This may help to delay the development of problems that are related to AIDS or HIV disease.

Apo Nevirapine Er may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Nevirapine Er may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Nevirapine Er may not be used for all of the conditions discussed here.

Your doctor may have suggested Apo Nevirapine Er for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Apo Nevirapine Er, speak to your doctor. Do not stop taking Apo Nevirapine Er without consulting your doctor.

Do not give Apo Nevirapine Er to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Apo Nevirapine Er if their doctor has not prescribed it.

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Apo Nevirapine ER Dosage

The recommended adult dose of nevirapine is 200 mg once a day for the first 2 weeks, and then 200 mg twice a day (every 12 hours) or 1 tablet of 400 mg extended release nevirapine once a day (every 24 hours) after the initial 2 weeks. Your doctor may decide on a different dosing pattern. Do not change your dose unless instructed by your doctor. The initial dose of 200 mg once daily helps to reduce the risk of rash that may develop with use of nevirapine. If you do develop a rash while taking Apo Nevirapine Er, call your doctor for further instruction.

Apo Nevirapine Er may be taken with or without food. Do not crush or chew the extended release tablets.

It is important to take Apo Nevirapine Er exactly as prescribed by your doctor. The effectiveness of the medicine depends on maintaining the right amount of nevirapine in the bloodstream. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss many doses in a row, talk to your doctor about how to resume dosing.

If you have been asked to stop taking the medication for more than a 7-day period, your doctor will likely have you start taking only one 200 mg tablet daily for the first 14 days and then increase to 200 mg twice daily after that.

Store nevirapine tablets at room temperature and protect them from excessive light and moisture. Keep the bottle tightly closed and out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Apo Nevirapine ER Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Apo Nevirapine Er. If you are concerned about side effects, discuss the risks and benefits of Apo Nevirapine Er with your doctor.

The following side effects have been reported by at least 1% of people taking Apo Nevirapine Er. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal or stomach pain
  • Diarrhea
  • fatigue
  • headache
  • nausea
  • sleepiness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • aching joints and muscles
  • increased blood pressure
  • increased fat on the upper back, neck, breasts, and around the trunk; and loss of fat from the legs, arms, and face
  • mild-to-moderate skin rash (e.g., itching, Hives, redness)
  • pain, numbness, or tingling of hands, arms, legs, or feet
  • signs of Anemia (low red blood cells; e.g., pale skin, unusual tiredness or weakness)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • tingling, burning, or prickly sensations
  • unusual tiredness or weakness
  • vomiting

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • flu-like symptoms (e.g., chills, Fever, or sore throat)
  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of a severe skin reaction (e.g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or muscle or joint pain)
  • signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • sores or ulcers in the mouth

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Nevirapine Er.

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We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

Apo Nevirapine ER Available Form

Each yellow, oval, biconvex, extended-release tablet engraved with "APO" on one side and "NV400" on the other side contains 400 mg of nevirapine. Nonmedicinal ingredients: hypromellose, methylcellulose, magnesium stearate, yellow iron oxide.

Apo Nevirapine ER Contraindications

Do not take nevirapine if you:

  • are allergic to nevirapine or any ingredients of Apo Nevirapine Er
  • have needed to stop taking the medication due to severe rash, allergic reactions, or hepatitis caused by nevirapine
  • have severely reduced liver function
  • ​​have galactose intolerance, Lapp lactase deficiency (a rare hereditary condition), or glucose-galactose malabsorption​
  • are taking the herbal medication St. John’s wort

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Apo Nevirapine ER Precautions

There may be an interaction between nevirapine and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Apo Nevirapine Er. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Apo Nevirapine ER Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Nevirapine Er.

Birth control: Nevirapine may reduce the effectiveness of birth control pills. Use another form of birth control if taking Apo Nevirapine Er.

Fat redistribution: Over time, Apo Nevirapine Er may change how fat is distributed in your body and may change your body shape. You may notice increased fat in the upper back and neck, breast, around the back, chest, and stomach area; or loss of fat from the legs, arms, and face. The long-term effects of this are not known.

Immune reconstitution syndrome: Apo Nevirapine Er may cause immune reconstitution syndrome, where signs and symptoms of inflammation from previous infections appear. These symptoms occur soon after starting anti-HIV medication and can vary. They are thought to occur as a result of the immune system improving and being able to fight infections that have been present without symptoms (such as pneumonia, herpes, or Tuberculosis). Report any new symptoms to your doctor as soon as possible.

Kidney function: If you have reduced kidney function, discuss with your doctor how Apo Nevirapine Er may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Nevirapine Er, and whether any special monitoring is needed. People with severely reduced kidney function should not take Apo Nevirapine Er.

Liver damage: Apo Nevirapine Er may cause liver damage. The risk is highest during the first 6 weeks of treatment. Women are also more likely than men to experience liver damage when taking nevirapine. Women who had CD4+ counts of over 250 cells/mm³ or men who had CD4+ counts of over 400 cells/mm³ when treatment was started are at a higher risk, but anyone taking Apo Nevirapine Er may be at risk of liver damage.

Your doctor will order regular blood tests to watch for early signs of liver damage. Stop using Apo Nevirapine Er and contact your doctor as soon as possible if you notice any symptoms of liver damage, including unusual tiredness or weakness, abdominal pain, loss of appetite, or jaundice (yellow eyes or skin).

Liver function: Nevirapine is broken down by the liver so it can be removed from the body through the kidneys. Liver disease or reduced liver function may cause a build-up of nevirapine in the body and cause side effects.

If you have liver disease or decreased liver function, discuss with your doctor how Apo Nevirapine Er may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Nevirapine Er, and whether any special monitoring is needed.

If you experience symptoms of liver problems (e.g., abdominal pain, persistent vomiting, feeling unwell, fever, itching, yellowing of the skin and eyes, dark urine), contact your doctor immediately.

Skin reactions: Nevirapine can cause a severe form of skin reaction that may be life threatening. This is most likely to occur in the first 6 weeks of taking Apo Nevirapine Er. If you experience a severe rash or a rash at the same time as fever, feeling generally unwell, blisters, muscle or joint aches, contact your doctor or get medical attention immediately.

Pregnancy: There are no adequate studies on the use of Apo Nevirapine Er by pregnant women. Talk to your doctor for guidance.

Breast-feeding: It is not known if nevirapine passes into breast milk. Women who have HIV infection are cautioned against breast-feeding because of the risk of passing HIV to a baby who does not have the infection.

Children: The safety and effectiveness of Apo Nevirapine Er have not been established for those less than 15 years of age.

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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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