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This combination product contains two medications: Saxagliptin and Metformin. Together they work to control blood glucose levels.
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This combination product contains two medications: Saxagliptin and Metformin. Together they work to control blood glucose levels. Metformin belongs to the class of medications called oral hypoglycemics, which are medications that lower blood sugar. Saxagliptin belongs to the group of medications called DPP-4 inhibitors. It works by increasing the amount of incretin released by the intestine. Incretin is a hormone that raises insulin levels when blood sugar is high and decreases the amount of sugar made by the body. These medications are used to control blood glucose (blood sugar) for people with Type 2 Diabetes when diet, exercise, and weight reduction have not been found to lower blood glucose well enough on their own. Komboglyze should be used as part of an overall diabetes management plan that includes a diet and exercise program.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of Komboglyze may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Komboglyze may not be used for all of the conditions discussed here.
Your doctor may have suggested Komboglyze for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Komboglyze, speak to your doctor. Do not stop taking Komboglyze without consulting your doctor.Do not give Komboglyze to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Komboglyze if their doctor has not prescribed it.
The recommended daily dose of saxagliptin-metformin is based on the dose needed to effectively control blood glucose levels and how side effects are tolerated. The usual starting dose for adults who have not been taking saxagliptin is the dose of the metformin you are taking plus saxagliptin 2.5 mg taken twice daily. If you are switching from taking saxagliptin and metformin separately, you may be prescribed the saxagliptin-metformin equal to that which you are currently taking. The maximum daily dose is 5 mg saxagliptin and 2000 mg metformin.
Komboglyze should be taken twice daily with meals, to reduce the stomach side effects that metformin can cause.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that Komboglyze be taken exactly as prescribed by your doctor.If you miss a dose, take it as soon as possible with food and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Komboglyze at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Komboglyze. If you are concerned about side effects, discuss the risks and benefits of Komboglyze with your doctor.
The following side effects have been reported by at least 1% of people taking Komboglyze. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Komboglyze.
2.5 mg/500 mg
Each pink, biconvex, round, film-coated tablet with "2.5/500" printed on one side and "4245" printed on the reverse side in blue ink contains saxagliptin 2.5 mg and metformin 500 mg. Nonmedcinal ingredients: magnesium stearate and povidone. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, Polyethylene Glycol 3350, titanium dioxide, talc, and red iron oxide.
2.5 mg/850 mg
Each light brown to brown, biconvex, round, film-coated tablet with "2.5/850" printed on one side and "4246" printed on the reverse side in blue ink contains saxagliptin 2.5 mg and metformin 850 mg. Nonmedicinal ingredients: magnesium stearate and povidone. In addition, the film coatings contain the following inactive ingredients: polyvinyl alcohol, polyethylene glycol 3350, titanium dioxide, talc, and yellow iron oxide.
2.5 mg/1000 mg
Each pale yellow to light yellow, biconvex, oval shaped, film-coated tablet with "2.5/1000" printed on one side and "4247" printed on the reverse side in blue ink contains saxagliptin 2.5 mg and metformin 1000 mg. Nonmedicinal ingredients: magnesium stearate and povidone. In addition, the film coatings contain the following inactive ingredients: polyvinyl alcohol, polyethylene glycol 3350, titanium dioxide, talc, or a combination of red and yellow iron oxides.
Do not take saxagliptin-metformin if you:
There may be an interaction between saxagliptin-metformin and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Komboglyze. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Komboglyze.
Alcohol intake: Alcohol may increase the risk of developing lactic acidosis for people who take metformin. Avoid drinking large amounts of alcohol if you are taking this medication.
Blood sugar control: If you develop or have fever, trauma, infection, or surgery, a temporary loss of blood sugar control may occur. If this happens, your doctor may think it is necessary to stop Komboglyze and temporarily inject insulin. This medication may be started again after the problem is resolved. Talk to your doctor if you have fever, infection, or are about to undergo surgery.
Blood sugar monitoring: Monitor your blood sugar regularly at intervals as discussed with your doctor or diabetes educator.
Congestive Heart Failure (CHF): The safety of taking saxagliptin when you have congestive heart failure (CHF) has not been studied. When metformin is used by people with CHF, there is an increased risk of developing lactic acidosis. If you have CHF, discuss with your doctor how Komboglyze may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Komboglyze, and whether any special monitoring is needed.
Diet: Saxagliptin-metformin is a treatment to be taken in combination with a proper diet. It is not a substitute for proper diet.
Immune system: If you have a weakened immune system (e.g., you have had an organ transplant or have HIV), discuss with your doctor how Komboglyze may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Komboglyze, and whether any special monitoring is needed.
Kidney function: Kidney Disease or reduced kidney function may cause Komboglyze to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Komboglyze may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Komboglyze, and whether any special monitoring is needed.
Lactic acidosis: Lactic acidosis is a rare but serious problem that occurs when metformin builds up in the body (i.e., the body doesn't get rid of it fast enough) during treatment. If you have severe kidney disease you are at higher risk of developing lactic acidosis. Since alcohol may increase the risk of lactic acidosis, do not drink a lot of alcohol over the short- or long-term while taking Komboglyze. When it does occur (very rarely), it is fatal in 50% of cases.. If you experience symptoms of lactic acidosis (e.g., weakness, tiredness, drowsiness, unusual muscle pain, trouble breathing, stomach pain with nausea, vomiting or diarrhea, feeling cold, dizziness, light-headedness, or slow or irregular heartbeat), stop taking Komboglyze and get immediate medical attention.
Liver function: Liver disease or reduced liver function may cause Komboglyze to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Komboglyze may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Komboglyze, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Komboglyze.
Pancreatitis: Saxagliptin-metformin can cause the pancreas to become inflamed. People with a history of pancreatitis, gallstones, Alcoholism, or high triglycerides, may be more at risk of experiencing this. If you have a history of pancreatitis, discuss with your doctor how Komboglyze may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Komboglyze, and whether any special monitoring is needed.
Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your doctor immediately.
Vitamin B12 levels: Metformin may decrease vitamin B12 levels. Your doctor will monitor your B12 levels with blood tests while you are taking Komboglyze.
Pregnancy: Komboglyze should not be used during pregnancy. If you become pregnant while taking Komboglyze, contact your doctor immediately.
Breast-feeding: It is not known if saxagliptin or metformin pass into breast milk. If you are a breast-feeding mother and are taking Komboglyze, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Komboglyze have not been established for children.Seniors: Seniors are more likely to have reduced kidney function and as a result may experience more side effects from Komboglyze.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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