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Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists. Apo Ondansetron is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation.
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Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists. Apo Ondansetron is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation. It is also used to prevent and treat the nausea and vomiting that occurs after surgery. It works by reducing the effects of a naturally-occurring chemical in the body called serotonin, which causes nausea and vomiting.
Apo Ondansetron may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Ondansetron may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Ondansetron may not be used for all of the conditions discussed here.
Your doctor may have suggested Apo Ondansetron for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Apo Ondansetron, speak to your doctor. Do not stop taking Apo Ondansetron without consulting your doctor.
Do not give Apo Ondansetron to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Apo Ondansetron if their doctor has not prescribed it.
The recommended adult dose of ondansetron for nausea and vomiting caused by chemotherapy is based on severity of the symptoms and ranges from 8 mg to 24 mg daily given in divided doses.
Doses for children are based on body size. The recommended dose for children is 3 to 5 mg per square metre of body surface area and will be calculated by your doctor.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one given here, do not change the way that you are taking the medication without consulting your doctor.
Ondansetron should be taken ½ to 1 hour before chemotherapy treatment. After this first dose, it should be taken every 8 to 12 hours for up to 5 days.
Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.
The recommended adult dose of ondansetron to treat and prevent nausea and vomiting caused by radiation therapy is 8 mg taken by mouth, 1 to 2 hours before treatment, and then every 8 hours for up to 5 days after treatment.
The recommended adult dose of ondansetron to prevent nausea and vomiting caused by surgery is 16 mg taken by mouth, 1 hour before anesthesia. Alternatively a dose of 4 mg may be given by intravenous (into a vein) injection at the time of surgery. After surgery, a single dose of 4 mg of ondansetron may be given by intravenous injection to treat nausea or vomiting.
Ondansetron is not effective for treating or preventing nausea and vomiting caused by motion.
It is important to take Apo Ondansetron exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store all forms of Apo Ondansetron at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Apo Ondansetron. If you are concerned about side effects, discuss the risks and benefits of Apo Ondansetron with your doctor.
The following side effects have been reported by at least 1% of people taking Apo Ondansetron. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Ondansetron.
Each oval-shaped, yellow, unscored, film-coated tablet, imprinted "APO" on one side and "OND4" on the other, contains ondansetron 4 mg (as hydrochloride dihydrate). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, polyethylene glycol, povidone, titanium dioxide, and a yellow colouring agent containing yellow iron oxide.
Each oval-shaped, yellow, unscored, film-coated tablet, imprinted "APO" on one side and "OND8" on the other, contains ondansetron 8 mg (as hydrochloride dihydrate). Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, polyethylene glycol, povidone, titanium dioxide, and a yellow colouring agent containing yellow iron oxide.
Do not take Apo Ondansetron if you:
There may be an interaction between ondansetron and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Apo Ondansetron. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Ondansetron.
Allergy: People who have had an allergic reaction to Dolasetron or Granisetron are advised not to take ondansetron. Before you take ondansetron, inform your doctor about any previous adverse reactions you have had to medications. Contact your doctor at once if you experience signs of an allergic reaction such as skin rash, itching, difficulty breathing, or swelling of the face and throat.
Abnormal heart rhythms: Very rarely, ondansetron can affect the heart's electrical activity and cause an irregular heartbeat. This is more likely to happen with the injectable form of ondansetron. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with ondansetron. You are more at risk for this type of abnormal heart rhythm and its complications if you:
If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Apo Ondansetron may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ondansetron, and whether any special monitoring is needed. Your doctor may monitor your heart rate using a test called an electrocardiogram (ECG) while you are using Apo Ondansetron.
Liver function: Ondansetron is broken down and removed from the body by the liver. Decreased liver function slows down the removal of the medication from the body and increases the risk of side effects from ondansetron. If you have liver disease or reduced liver function, discuss with your doctor how Apo Ondansetron may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Ondansetron, and whether any special monitoring is needed.
Motion Sickness: Ondansetron is not effective for the treatment of motion sickness.
Neuroleptic malignant syndrome (NMS): Ondansetron, like other similar medications, can cause a potentially fatal syndrome known as neuroleptic malignant syndrome (NMS). If you notice the symptoms of NMS such as high fever, muscle stiffness, confusion or loss of consciousness, sweating, racing or irregular heartbeat, or fainting, get immediate medical attention.
Phenylketonuria: People with phenylketonuria (lacking the enzyme needed to break down phenylalanine) should take forms of ondansetron other than oral dissolving tablets (ODT). The ODT form of ondansetron contains aspartame, an ingredient that cannot be broken down in the body by people who have phenylketonuria.
Serotonin syndrome: Severe reactions are possible when ondansetron is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat Depression. These combinations must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. Coma and death are possible.
Pregnancy: The safety of ondansetron for use by pregnant women has not been established. Apo Ondansetron should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Apo Ondansetron, contact your doctor immediately.
Breast-feeding: It is not known if ondansetron passes into breast milk. If you are a breast-feeding mother and are taking Apo Ondansetron, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Apo Ondansetron to treat nausea and vomiting caused by chemotherapy have not been established for children under 3 years of age. The safety and effectiveness of using Apo Ondansetron to treat nausea and vomiting caused by radiation or surgery have not been determined for children less than 18 years of age. Its use by this age group is not recommended.
Seniors: The safety and effectiveness of using Apo Ondansetron by people 65 years or older to treat nausea and vomiting caused by surgery have not been established. Seniors may be at an increased risk of developing irregular heart beat with ondansetron, particularly the injectable form. Talk to your doctor about any concerns you may have.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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