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Combigan is an ophthalmic solution (eye drops) that combines two medications: brimonidine and Timolol. Brimonidine belongs to the class of medications called alpha-2 adrenergic receptor agonists.
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Combigan is an ophthalmic solution (eye drops) that combines two medications: brimonidine and Timolol. Brimonidine belongs to the class of medications called alpha-2 adrenergic receptor agonists. Timolol belongs to the class of medications called beta-adrenergic receptor blockers (also known as "beta-blockers").
Brimonidine - timolol eye drops reduce the volume of liquid produced in the eye and increase the drainage of fluid from the eye. Combigan is intended for use by people with chronic open-angle Glaucoma or by people with ocular hypertension (high pressure in the eye) who are not responsive to treatment with only one medication and are considered appropriate candidates for combination therapy. Combigan may also be used by people who have intra-ocular pressure that fluctuates over long periods of time.
Combigan may be available under multiple brand names and/or in several different forms. Any specific brand name of Combigan may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Combigan may not be used for all of the conditions discussed here.
Your doctor may have suggested Combigan for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are using Combigan, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give Combigan to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Combigan if it has not been prescribed by their doctor.
The usual dose is one drop in the morning and one drop in the evening (about 12 hours apart) in the affected eye(s). Do not let the tip of the bottle touch your eye or any other surface. If you use other eye drops, wait at least 10 minutes before using them. If you wear soft contact lenses, take them out before putting in the drops, then wait at least 15 minutes after using the drops before putting your soft contact lenses back in. Read the product leaflet for directions on proper use of the eyedrops.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one given here, do not change the way you are using the medication without consulting your doctor.
It is important to use Combigan exactly as prescribed by your doctor. If you miss a dose, use it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Combigan at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Combigan. If you are concerned about side effects, discuss the risks and benefits of Combigan with your doctor.
The following side effects have been reported by at least 1% of people taking Combigan. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Combigan.
Each mL of ophthalmic solution contains brimonidine tartrate 2 mg (0.2%) and timolol maleate 5 mg (0.5 %). Nonmedicinal ingredients: benzalkonium chloride 0.005% as preservative, purified water, sodium phosphate, monobasic monohydrate, sodium phosphate, and dibasic heptahydrate. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH.
Do not use brimonidine - timolol eye drops if you:
Do not give Combigan to children under 2 years of age.
There may be an interaction between brimonidine - timolol eye drops and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Combigan. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, Nicotine from cigarettes, and street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Combigan.
Absorption: Combigan is to be used only as a topical (surface-only) treatment for the eyes; however, as with many eye medications, it is absorbed into the bloodstream. The same side effects of systemic (oral) beta-adrenergic receptor blockers may occur with Combigan. These side effects include shortness of breath, dizziness, lightheadedness, skin rash, or slow heartbeat.
Allergy: Some people who are allergic to other alpha-agonists or beta-blockers experience allergic reactions to brimonidine - timolol. Before you use Combigan, inform your doctor about any previous adverse reactions you have had to medications.
Contamination: Eye drops can become contaminated with bacteria if the tip of the dropper touches any surface, including your eye. This can cause Eye Infections, which may lead to serious eye damage and loss of vision.
Contact lenses: The preservative in these eye drops may be absorbed by soft contact lenses. You should wait at least 15 minutes after using Combigan before putting in your soft contact lenses.
Drowsiness/reduced alertness: Combigan may cause fatigue and/or drowsiness. Avoid driving, using machinery, or doing hazardous activities until you determine how the medication affects you.
Heart disease: People with heart conditions, such as heart block, heart failure or Angina, may experience increased symptoms of their condition when using this eye drop. If you have any medical condition that may be affected by low blood pressure or reduced heart rate, discuss with your doctor how Combigan may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Combigan, and whether any special monitoring is needed. Medical conditions that may be affected include:
Medical conditions: If you have any of the following medical conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Combigan, and whether any special monitoring is needed.
Pregnancy: Combigan should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Combigan, contact your doctor immediately.
Breast-feeding: Timolol passes into breast milk after being used as an eye drop. It is not known if brimonidine passes into human breast milk. If you are a breast-feeding mother and are taking brimonidine - timolol, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Combigan have not been established for children.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
December 18, 2023
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