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Index

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Dosage

Dosage
Side Effects
Available Form
Contraindications
Precautions
Warnings

Forxiga®

Dosage

When used to improve control of blood glucose levels, the recommended starting dose for Forxiga (Dapagliflozin) is 5 mg taken by mouth once a day. Your doctor may adjust the dose up to a maximum of 10 mg daily, depending on how effective it is and how well it is tolerated.

The recommended dose to reduce the risk of hospitalization due to heart failure is 10 mg taken by mouth, once a day.

Forxiga (Dapagliflozin) should be taken at the same time every day. The tablets should be swallowed whole with some fluid and may be taken with food or on an empty stomach.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are administering the medication without consulting your doctor.

It is important to take Forxiga (Dapagliflozin) exactly as prescribed by your doctor. Do not stop using the medication because you feel better. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Forxiga (Dapagliflozin) at room temperature, protect from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Steglatro®

Dosage

The recommended starting dose of Steglatro (Ertugliflozin) is 5 mg taken by mouth, once daily, in the morning. It may be taken with or without food. If your blood sugar level doesn't decrease enough, and additional glucose control is needed, your doctor may gradually increase the dose to a maximum of 15 mg taken once daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Steglatro (Ertugliflozin) exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Steglatro (Ertugliflozin) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Forxiga®

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Forxiga (Dapagliflozin). If you are concerned about side effects, discuss the risks and benefits of Forxiga (Dapagliflozin) with your doctor.

The following side effects have been reported by at least 1% of people taking Forxiga (Dapagliflozin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

back pain
Constipation
Diarrhea
flu-like illness
headache
nausea
pain in the arms, legs, hands, or feet
rash
sore throat

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

dizziness or lightheadedness when rising from a sitting or lying position
pain, tenderness, or swelling in the genital area
redness or rash of the penis or foreskin (yeast infection)
signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
signs of vaginal yeast infection (e.g., vaginal odour, curd-like discharge, itching)
symptoms of kidney infection (e.g., painful, urgent, or frequent need to urinate; lower back pain; Fever or chills; cloudy or foul smelling urine; blood in urine)
symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness, blurred vision)
symptoms of a urinary tract infection (e.g., pain when urinating, urinating more often than usual, low back or flank pain, strong odour)

Stop taking the medication and seek immediate medical attention if any of the following occur:

severe dehydration (e.g., confusion, sweating stops, heart palpitations)
severe Hypoglycemia (low blood sugar; disorientation, loss of consciousness, seizure)
signs of ketoacidosis (e.g., confusion, extreme thirst, loss of appetite, stomach pain, trouble breathing, nausea, vomiting, or unusual tiredness)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
symptoms of a serious infection (e.g., fever, chills, rapid breathing or heartbeat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Forxiga (Dapagliflozin).

Steglatro®

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Steglatro (Ertugliflozin). If you are concerned about side effects, discuss the risks and benefits of Steglatro (Ertugliflozin) with your doctor.

The following side effects have been reported by at least 1% of people taking Steglatro (Ertugliflozin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

headache
thirst

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Low Blood Pressure (e.g., dizziness when standing, fainting, lightheadedness)
redness or rash of the penis or foreskin (yeast infection)
signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, painful or difficult urination)
skin ulcers or sores
symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness, blurred vision)
symptoms of a kidney infection (e.g., painful, frequent or urgent need to urinate, Fever or chills, cloudy or foul smelling urine, blood in the urine)
symptoms of vaginal yeast infection (women; e.g., vaginal odour, curd-like discharge, itching)
symptoms of yeast infection of the penis (men; e.g., lumpy, odorous discharge under foreskin; red, swollen, itchy head of the penis; pain when urinating or during sexual activity)

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of diabetic ketoacidosis (e.g., difficulty breathing, nausea, vomiting, stomach pain, loss of appetite, confusion, extreme thirst, and unusual tiredness)
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of a severe infection that has spread throughout the body (sepsis; fever, rapid breathing, fast heartbeat, pain or difficult urination)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Steglatro (Ertugliflozin).

Forxiga®

Precautions

There may be an interaction between Forxiga (Dapagliflozin) and any of the following:

alpha lipoic acid
androgens (e.g., testosterone)
Aspirin (Asa)
atypical antipsychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
Buserelin
Ceritinib
chloroquine
Dabrafenib
Danazol
other diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
Disopyramide
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
Everolimus
Glucagon
Goserelin
Hepatitis C antivirals (e.g., daclatasvir, dasabuvir, glecaprevir and pibrentasvir, ledipasvir, paritaprevir, ombitasvir, sofosbuvir, velpatasvir)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
hydroxychloroquine
inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
Lanreotide
Leuprolide
mifepristone
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
Octreotide
oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
Pasireotide
Pegvisomant
pentamidine
progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
quinine
quinolone antibiotics (e.g., ciprofloxacin, levofloxacin)
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
Sirolimus
somatostatin
somatotropin
sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
Sunitinib
Tacrolimus
Temsirolimus
Tramadol
Triptorelin
Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Forxiga (Dapagliflozin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Steglatro®

Precautions

There may be an interaction between Steglatro (Ertugliflozin) and any of the following:

acetylsalicylic acid (Asa)
atypical antipsychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
blood pressure medications
corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
diabetes medications (e.g., chlorpropamide, Glyburide, Metformin, Rosiglitazone)
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
Disopyramide
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
Glucagon
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
insulin
Lanreotide
mifepristone
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
Niacin
Nilotinib
Octreotide
Pasireotide
pentamidine
progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
quinine
quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
Sirolimus
somatostatin acetate
sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
Sunitinib
Tacrolimus
testosterone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Steglatro (Ertugliflozin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Forxiga®

Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Forxiga (Dapagliflozin).

Cholesterol: Forxiga (Dapagliflozin) may cause increases in the levels of low-density lipoprotein (LDL) cholesterol in your blood. If you have High Cholesterol, discuss with your doctor how Forxiga (Dapagliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Forxiga (Dapagliflozin), and whether any special monitoring is needed.

Dizziness: Some people taking Forxiga (Dapagliflozin) may experience decreases in blood pressure. This occurs because the medication causes an increased amount of fluid, along with the glucose, to be removed from the body through the kidneys. These blood pressure drops could lead to dizziness, lightheadedness, and falls. This may occur when you shift your body position, such as rising from a sitting or lying position. If you experience this problem, try getting up more slowly. If it persists or if you faint, contact your doctor. Seniors and other individuals who are at risk of experiencing Low Blood Pressure (e.g., dehydration, taking medications for high blood pressure) should discuss with their doctor how Forxiga (Dapagliflozin) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Forxiga (Dapagliflozin), and whether any special monitoring is needed.

Driving and using machines: Forxiga (Dapagliflozin) may cause dizziness or lightheadedness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how Forxiga (Dapagliflozin) affects you.

Glucose control: When Forxiga (Dapagliflozin) is taken along with other medications for diabetes, glucose levels may drop too far, causing confusion, cold sweats, cool and pale skin, headache, fast heartbeat, or weakness. Your doctor may suggest decreasing the dose of your other medications when you first start taking Forxiga (Dapagliflozin). If you take other medications for diabetes or medications that can decrease blood glucose levels, discuss with your doctor how Forxiga (Dapagliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Forxiga (Dapagliflozin), and whether any special monitoring is needed.

Ketoacidosis: There have been reports that diabetic ketoacidosis has been experienced by people taking Forxiga (Dapagliflozin) and other similar medications. Ketoacidosis is a serious condition that occurs when the body does not have enough insulin to use the glucose in the blood. As a result, the body starts to break down fat for energy. This can cause ketones to build up in the blood, making it more acidic. This is a warning sign that your diabetes is out of control.

If you experience high blood glucose levels, thirst, very Dry Mouth or frequent urination, you may be experiencing early signs of ketoacidosis. Contact your doctor as soon as possible for advice on how to manage this condition.

Kidney function: The effectiveness of Forxiga (Dapagliflozin) depends on kidney function because it increases the amount of glucose eliminated through the kidneys. Over time, Forxiga (Dapagliflozin) may cause kidney problems. If you experience signs of kidney problems, such as puffy hands, face, or feet; high blood pressure; unusual muscle cramping; or darkened urine, Forxiga (Dapagliflozin) may be affecting how well your kidneys are working. If you notice any of these symptoms, contact your doctor as soon as possible.

Liver function: If you have liver problems, discuss with your doctor how Forxiga (Dapagliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Forxiga (Dapagliflozin), and whether any special monitoring is needed. Forxiga (Dapagliflozin) is not recommended for people with severely decreased liver function.

Yeast infections: There is an increased risk of developing genital or vaginal yeast infections when taking Forxiga (Dapagliflozin) as a result of increased glucose in the urine. This is more likely to occur for uncircumcised males and for people who have a history of yeast infections.

Pregnancy: Forxiga (Dapagliflozin) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Forxiga (Dapagliflozin), contact your doctor immediately.

Breast-feeding: It is not known if Forxiga (Dapagliflozin) passes into breast milk. If you are a breast-feeding mother and are taking Forxiga (Dapagliflozin), it may affect your baby. Breast-feeding is not recommended when you are taking Forxiga (Dapagliflozin).

Children: The safety and effectiveness of Forxiga (Dapagliflozin) have not been established for children less than 18 years of age.

Seniors: Seniors are more likely to experience side effects with Forxiga (Dapagliflozin) and may require lower doses.

Steglatro®

Warnings

Amputation: There may be an increased risk for lower leg or toe amputations in people taking Steglatro (Ertugliflozin). Good foot care is very important for people with diabetes. Contact your doctor as soon as possible if you notice symptoms of leg pain, poor circulation, bluish, cold skin, and poor hair or toenail growth.

Dehydration: Steglatro (Ertugliflozin) may cause an increased amount of fluid to be removed from the body, resulting in dehydration. Dehydration can cause decreased blood pressure and also contribute to heart problems. Certain other medications, such as diuretics (water pills) can cause dehydration. If you experience symptoms of dehydration, such as thirst, decreased urine or tear production, dizziness or Headaches, contact your doctor.

Diabetic ketoacidosis (DKA): Steglatro (Ertugliflozin) has been associated with DKA. This is a potentially life-threatening condition that occurs when the body does not have enough insulin to use the glucose in the bloodstream. When this happens, the body starts to burn ketones for fuel instead, which can make the blood acidic. This condition is more likely to develop if you are following a very low carbohydrate diet, are dehydrated, or have consumed a large amount of alcohol. Symptoms of DKA include difficulty breathing, nausea, vomiting, abdominal pain, confusion, loss of appetite, excessive thirst, and unusual fatigue or sleepiness. If you experience these symptoms, get immediate medical help.

Dizziness: Some people taking Steglatro (Ertugliflozin) may experience decreases in blood pressure. This occurs because the medication causes an increased amount of fluid to be removed from the body through the kidneys. These blood pressure drops could lead to dizziness, lightheadedness, and falls. This may occur when you shift your body position, such as rising from a sitting or lying position. If you experience this problem, try getting up more slowly. If it persists or if you faint, contact your doctor.

Glucose control: When Steglatro (Ertugliflozin) is taken along with other medications for diabetes, glucose levels may drop too far, causing confusion, cold sweats, cool and pale skin, headache, fast heartbeat, or weakness. Your doctor may suggest decreasing the dose of your other medications when you first start taking Steglatro (Ertugliflozin). If you take other medications for diabetes, discuss with your doctor how Steglatro (Ertugliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Steglatro (Ertugliflozin) may cause a decrease in kidney function. If you have reduced kidney function or kidney disease, discuss with your doctor how Steglatro (Ertugliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Steglatro (Ertugliflozin), and whether any special monitoring is needed.

Urinary Tract Infections: Steglatro (Ertugliflozin) has been associated with urinary tract infections, including kidney infections and blood infections caused by bacteria spreading from the urinary tract. If you experience symptoms of a urinary tract infection, such as a burning feeling when you urinate, pain or pressure in your back or lower abdomen, cloudy, dark, bloody or strange-smelling urine, or fever or chills, contact your doctor as soon as possible.

Yeast infections: There is an increased risk of developing genital or vaginal yeast infections when taking Steglatro (Ertugliflozin) as a result of increased glucose in the urine. This is more likely to occur for uncircumcised males and for people who have a history of yeast infections.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Steglatro (Ertugliflozin), contact your doctor immediately.

Breast-feeding: It is not known if Steglatro (Ertugliflozin) passes into breast milk. If you are a breast-feeding mother and are taking Steglatro (Ertugliflozin), it may affect your baby. It is recommended that women do not breast-feed if they are taking this medication.

Children: The safety and effectiveness of using Steglatro (Ertugliflozin) have not been established for children.

Seniors: People over the age of 65 are more likely to experience side effects of taking Steglatro (Ertugliflozin). Doses for seniors should generally be lower and increase more slowly than for other adults.

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Compare Drug Information

Index

Dosage

Forxiga®

Dosage

Steglatro®

Dosage

Forxiga®

Side Effects

Steglatro®

Side Effects

Forxiga®

Available Form

Steglatro®

Available Form

Forxiga®

Contraindications

Steglatro®

Contraindications

Forxiga®

Precautions

Steglatro®

Precautions

Forxiga®

Warnings

Steglatro®

Warnings

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