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Zydelig

Zydelig

Idelalisib

Zydelig (Idelalisib) belongs to the group of cancer-fighting medications known as antineoplastics and more specifically to a class of medications called kinase inhibitors. These medications slow the reproduction of cancerous cells and kills cancerous cells.

Available form

Tablet

Dosage

100mg, 150mg

Manufacturers

Gilead Sciences

Generic brand of

Idelalisib

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Zydelig information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended adult dose of Zydelig (Idelalisib) is 150 mg taken by mouth 2 times a day. Zydelig (Idelalisib) may be taken with food or on an empty stomach.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Zydelig (Idelalisib) exactly as prescribed by your doctor. If you miss a dose and it is more than 6 hours until your next dose, take it as soon as possible and continue with your regular schedule. If it is less than 6 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Zydelig (Idelalisib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Zydelig (Idelalisib). If you are concerned about side effects, discuss the risks and benefits of Zydelig (Idelalisib) with your doctor.

The following side effects have been reported by at least 1% of people taking Zydelig (Idelalisib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

cold symptoms (e.g., stuffy nose, cough)
decreased appetite
Diarrhea (mild)
fatigue
headache
heartburn
joint or muscle pain
mouth sores
nausea
night sweats
stomach pain
sun sensitivity
trouble sleeping
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Fever or chills
fluid retention (e.g., swelling of the feet, ankles, or lower leg)
rash
severe diarrhea
signs of breathing problems (e.g., shortness of breath, troubled breathing, wheezing, or tightness in chest, fast or irregular breathing)
signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
symptoms of a urinary tract infection (e.g., pain when urinating, urinating more often than usual, low back or flank pain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of a severe skin reaction (e.g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
symptoms of progressive multifocal leukoencephalopathy (e.g., difficulty walking, memory loss, trouble thinking, confusion, vision loss)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Zydelig (Idelalisib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Zydelig (Idelalisib).

Birth control: Women who may become pregnant should use effective birth control while taking Zydelig (Idelalisib) and for at least one month after stopping treatment. Because Zydelig (Idelalisib) may reduce the effectiveness of birth control pills, a barrier form of birth control should also be used.

Diarrhea: People receiving Zydelig (Idelalisib) have experienced severe diarrhea or inflammation of the bowel. If you have a history of inflammatory bowel disease, discuss with your doctor how Zydelig (Idelalisib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zydelig (Idelalisib), and whether any special monitoring is needed.

Gastrointestinal problems can cause diarrhea that may lead to dehydration (loss of too much water from the body). If you experience severe diarrhea for more than a day, or if you have diarrhea along with fever, decreased urination, dizziness, or a fast heartbeat, contact your doctor immediately.

Hypersensitivity syndrome: A Anaphylaxis (severe allergic reaction) called hypersensitivity syndrome has occurred for some people taking Zydelig (Idelalisib). Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.

Infection: As well as killing cancer cells, Zydelig (Idelalisib) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Serious and sometimes life-threatening infections can occur when taking Zydelig (Idelalisib). Antibiotics are often taken to prevent infections by certain bacteria during treatment with Zydelig (Idelalisib) and for several months after stopping Zydelig (Idelalisib).

Liver function: Liver disease or reduced liver function may cause Zydelig (Idelalisib) to build up in the body, causing side effects. Zydelig (Idelalisib) may also reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how Zydelig (Idelalisib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zydelig (Idelalisib), and whether any special monitoring is needed. Your doctor will want to test your liver function regularly with blood tests while you are taking Zydelig (Idelalisib).

Zydelig (Idelalisib) is not recommended for people with hepatitis or active liver disease.

Lung inflammation: Lung inflammation (pneumonitis) causing difficulty breathing has occurred on rare occasions for some people taking Zydelig (Idelalisib). This complication can be serious and sometimes fatal. If you experience new or worsening shortness of breath or cough (with or without fever) at any time while you are taking Zydelig (Idelalisib), contact your doctor immediately.

Progressive multifocal leukoencephalopathy (PML): There have been reports of PML after using Zydelig (Idelalisib). PML is a rare disorder that causes nerve damage in the brain. If you experience memory loss, vision loss, trouble thinking, or difficulty walking, contact your doctor immediately.

Sensitivity to sunlight: Zydelig (Idelalisib) may increase the sensitivity of the skin to sunlight, increasing the risk of Sunburn. Avoid exposure to sunlight for long periods of time, particularly between the hours of 10 am and 2 pm. Wear a broad-spectrum sunscreen and lip balm with an SPF of 30 or greater. If you notice any unusual skin rash or peeling, contact your doctor immediately.

Pregnancy: Zydelig (Idelalisib) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Zydelig (Idelalisib), contact your doctor immediately.

Breast-feeding: It is not known if Zydelig (Idelalisib) passes into breast milk. If you are breast-feeding and are taking Zydelig (Idelalisib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Zydelig (Idelalisib) have not been established for children.

Seniors: Seniors may be likely to experience severe side effects from Zydelig (Idelalisib).

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