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This is a combination product that contains 2 medications used to lower high blood pressure (hypertension), Losartan and Hydrochlorothiazide. Losartan belongs to the class of medications called angiotensin II receptor blockers.
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Losartan belongs to the class of medications called angiotensin II receptor blockers. They help to lower blood pressure by relaxing blood vessels. Hydrochlorothiazide belongs to the class of medications called diuretics or "water pills." It helps control blood pressure by getting rid of excess salt and water.
This combination medication is prescribed when your doctor feels it is appropriate for you to be taking both medications. It is usually prescribed after a person's blood pressure is stabilized on losartan and hydrochlorothiazide taken individually.
It usually takes 3 to 6 weeks to see the full effects of Hyzaar.
Hyzaar may be available under multiple brand names and/or in several different forms. Any specific brand name of Hyzaar may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Hyzaar may not be used for all of the conditions discussed here.
Your doctor may have suggested Hyzaar for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Hyzaar, speak to your doctor. Do not stop taking Hyzaar without consulting your doctor.
Do not give Hyzaar to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Hyzaar if their doctor has not prescribed it.
Once the dose of each medication (losartan and hydrochlorothiazide) has been determined, the combination tablets can be started. The recommended dose is one tablet once daily. The maximum dose is one tablet per day.
The medication can be taken with or without food, but should be taken consistently. This means that if you usually take it with food, continue to take it with food, and if you usually take it without food, continue to take it without food.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that Hyzaar be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Hyzaar at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Hyzaar. If you are concerned about side effects, discuss the risks and benefits of Hyzaar with your doctor.
The following side effects have been reported by at least 1% of people taking Hyzaar. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Hyzaar.
50 mg/12.5 mg
Each yellow, oval-shaped, film-coated tablet, marked with code "717" on one side and plain on the other, contains 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. Nonmedicinal ingredients: hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, quinoline yellow aluminum lake or D&C Yellow No. 10 Aluminum Lake, and titanium dioxide. May contain carnauba wax.
100 mg/12.5 mg
Each white-to-off-white, oval-shaped, film-coated tablet, with code "745" on one side and plain on the other, contains 100 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. Nonmedicinal ingredients: hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, and titanium dioxide. May contain carnauba wax.
Do not take losartan - hydrochlorothiazide if you:
There may be interaction between losartan - hydrochlorothiazide and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Hyzaar. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Hyzaar.
Allergic reaction: Some people who are allergic to sulfonamide medications also experience allergic reactions to hydrochlorothiazide. Before you take Hyzaar, inform your doctor about any previous adverse reactions you have had to medications, especially to sulfonamide antibiotics or diabetes medications. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.
Cholesterol: Cholesterol and triglyceride levels may increase when taking hydrochlorothiazide. Talk to your doctor about whether you will need to have your cholesterol levels tested while you are taking Hyzaar. If you have increased cholesterol or triglyceride levels, discuss with your doctor how Hyzaar may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Hyzaar, and whether any special monitoring is needed.
Diabetes: Hydrochlorothiazide may make it more difficult for people with diabetes to control their blood sugar levels. High blood sugar may occur, glucose tolerance may change, and diabetes may worsen. A dose adjustment of diabetes medications, including insulin, may be required. If you have diabetes, discuss with your doctor how Hyzaar may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Hyzaar, and whether any special monitoring is needed.
Electrolytes: The use of hydrochlorothiazide can reduce the levels of electrolytes such as potassium, sodium, magnesium, and chloride, and increase the levels of calcium. Your doctor will periodically check to see if these levels are in balance and a potassium supplement may be recommended. Warning signs or symptoms of fluid and electrolyte imbalance include:
Gout: An acute gout attack may occur in some patients taking losartan - hydrochlorothiazide as a result of high levels of uric acid in the blood. Symptoms of an acute gout attack include sudden pain, swelling, and stiffness in the affected joint, often the big toe. You may also experience a fever. If this is your first attack, seek medical attention as soon as possible. If you have had gout attacks before, follow your doctor's instructions for dealing with the attack.
Heart Problems: Losartan – hydrochlorothiazide can cause fluid to build up in the body, increasing the work the heart must do to keep the blood circulating. If you have had a recent Heart Attack, or you have Congestive Heart Failure, taking losartan – hydrochlorothiazide can make symptoms of these heart conditions worse. If you have a history of heart problems, discuss with your doctor how Hyzaar may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Hyzaar, and whether any special monitoring is needed.
Kidney function: Losartan – hydrochlorothiazide can cause changes to kidney function that may result in decreased kidney function, kidney failure, or possibly death. This is particularly likely for those who already have kidney problems. Certain people have experienced changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), nonsteroidal anti-inflammatory drugs (NSAIDs), or aliskiren may further increase risk of kidney problems for people already at risk for this problem. If you have reduced kidney function, renal artery stenosis (narrowing of blood vessels in the kidneys), or congestive heart failure, discuss with your doctor how Hyzaar may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Hyzaar, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause Hyzaar to build up in the body, causing side effects. People with reduced liver function may need a lower-than-normal dose of losartan; therefore, it may be necessary to use the components of the combination product separately. If you have reduced liver function or liver disease, discuss with your doctor how Hyzaar may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Hyzaar, and whether any special monitoring is needed. Hyzaar is not recommended for people with severe liver impairment.
Hyzaar may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Low blood pressure: Occasionally, a greater-than-expected drop in blood pressure occurs after taking Hyzaar. It is more likely to occur if you are taking additional diuretics (water pills), have reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be monitored more often in these situations. To reduce the risk of dizziness, those with low blood pressure or those just starting to take Hyzaar should stand or sit up slowly when getting up from a lying down or sitting position.
If low blood pressure causes you to faint or feel lightheaded, contact your doctor.
Excessive sweating and lack of fluid intake may lead to an excessive fall in blood pressure because of reduced fluid in your blood vessels. Vomiting or diarrhea may also lead to a fall in blood pressure. Consult your doctor if you feel your blood pressure is too low.
Lupus: There have been reports of a worsening or activation of lupus in people taking hydrochlorothiazide. If you have lupus, discuss with your doctor how Hyzaar may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Hyzaar, and whether any special monitoring is needed.
Potassium levels: Increases in blood levels of potassium occur for approximately 2% of people who take Hyzaar. This rarely causes problems, but your doctor will likely want to monitor your potassium levels through blood tests. Avoid using salt substitutes that contain potassium while you are taking losartan - hydrochlorothiazide.
Sensitivity to sunlight: Hyzaar may increase the sensitivity of the skin to sunlight, increasing the risk of Sunburn. Avoid exposure to sunlight for long periods of time, particularly between the hours of 10 am and 2 pm, while you are taking Hyzaar. Wear a broad-spectrum sunscreen and lip balm with an SPF of 30 or higher. If you notice any unusual skin rash or peeling, contact your doctor immediately.
Skin Cancer: Recent reviews of hydrochlorothiazide has connected long term use of the medication with an increased risk of developing non-melanoma skin cancer. This often appears as a lump or discoloured patch of skin that slowly changes appearance or size. Check your skin regularly for unusual growths or discolouration and report any changes to your doctor as soon as possible. Talk to your doctor about any concerns you may have.
Vision changes: Hydrochlorothiazide occasionally causes vision changes including increased eye pressure (Glaucoma) and myopia (Nearsightedness). If you experience any eye symptoms, such as pain or change in vision, contact your doctor as soon as possible.
Pregnancy: Losartan may cause severe harm to an unborn fetus if it is taken by the mother during pregnancy. Pregnant women should not take Hyzaar. If you become pregnant while taking Hyzaar, stop taking it immediately and call your doctor.
Breast-feeding: It is not known if losartan passes into breast milk. Hydrochlorothiazide does pass into breast milk. If you are a breast-feeding mother and are taking Hyzaar, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Hyzaar have not been established for children. Hyzaar is not recommended for children.
Seniors: Seniors may be more sensitive to the effects of Hyzaar and may experience more side effects.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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