Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Daklinza. If you are concerned about side effects, discuss the risks and benefits of Daklinza with your doctor.

The following side effects have been reported by at least 1% of people taking Daklinza. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Diarrhea
• headache
• nausea
• rash
• tiredness
• trouble sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
• slowed heart rate

Stop taking the medication and seek immediate medical attention if any of the following occur: signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Daklinza.

60 mg
Each light green, biconvex, pentagonal tablet, debossed with "BMS" on one side and "215" on the other, contains 60 mg of daclatasvir. Nonmedicinal ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, silicon dioxide and Opadry Green (FD&C Blue No. 2 / indigo carmine aluminum lake, hypromellose, iron oxide (yellow), polyethylene glycol 400, and titanium dioxide).

Do not take Daklinza if you:

• are allergic to daclatasvir or any ingredients of the medication
• are taking certain other medications, which include, but are not limited to
• Carbamazepine
• Dexamethasone
• Oxcarbazepine
• Phenobarbital
• Phenytoin
• rifabutin
• rifampin
• rifapentine
• St. John's wort

There may be an interaction between daclatasvir and any of the following:

• Aliskiren
• Amiodarone
• anticancer medications (e.g., Doxorubicin, Etoposide, Idarubicin, Irinotecan, Paclitaxel)
• antihistamines (e.g., bilastine, cetirizine, Desloratadine, Loratadine)
• antipsychotics (e.g., Haloperidol, Paliperidone, Risperidone)
• Aprepitant
• Bosentan
• Buprenorphine
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• carbamazepine
• Carvedilol
• Cobicistat
• Colchicine
• conivaptan
• Cyclosporine
• dabigatran
• Deferasirox
• dexamethasone
• diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
• Digoxin
• Dronedarone
• Edoxaban
• Elagolix
• Enzalutamide
• Eslicarbazepine
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Everolimus
• grapefruit juice
• other hepatitis C antivirals (e.g., grazoprevir, ledipasvir, voxilaprevir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Hydrocortisone
• ivermectin
• Lomitapide
• Loperamide
• lumacaftor
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Methotrexate
• mifepristone
• Mitotane
• Modafinil
• Morphine
• Nadolol
• Naloxegol
• Norfloxacin
• Ondansetron
• phenobarbital
• phenytoin
• primidone
• certain protein kinase inhibitors (e.g., Bosutinib, Dabrafenib, Dasatinib, imatinib, Pazopanib)
• Prucalopride
• quinidine
• quinine
• Ranitidine
• rifabutin
• rifampin
• rifaximin
• Riociguat
• Rivaroxaban
• Romidepsin
• St. John's wort
• Silodosin
• siltuximab
• Sirolimus
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Stiripentol
• Tacrolimus
• Tocilizumab
• Tolvaptan
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Daklinza. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Daklinza.

Diabetes: People with diabetes may experience loss of glucose control while taking daclatasvir. This may mean your blood glucose levels are unusually high or low. If you have diabetes, discuss with your doctor how Daklinza may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this mediation, and whether any special monitoring is needed. You should testing your blood glucose level more frequently while you are taking Daklinza.

Galactose intolerance: Daclatasvir is prepared with lactose. If you have lactose or galactose intolerance you should not take Daklinza.

Hepatitis B reactivation: People who have hepatitis B infection that is dormant may experience the infection returning, causing further liver dysfunction or liver failure. If you have a history of hepatitis B infection, discuss with your doctor how Daklinza may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this mediation, and whether any special monitoring is needed.

If you experience symptoms of worsening liver function, such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pregnancy: If you are not taking ribavirin, talk to your doctor about birth control. Effective birth control should be used while you are taking daclatasvir and for at least 5 weeks after stopping Daklinza.

Daklinza should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Daklinza, contact your doctor immediately.

Breast-feeding: It is not known if daclatasvir passes into breast milk. If you are a breast-feeding mother and are taking Daklinza, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Daklinza have not been established for children.