Calquence (Acalabrutinib) belongs to the class of medications called antineoplastics. Specifically, it is a protein kinase inhibitor. It is used to treat a type of cancer called Chronic Lymphocytic Leukemia (CLL). It is also used to treat mantle cell lymphoma (MCL), a form of non-Hodgkin’s lymphoma, after at least one other treatment has been tried.

It works by blocking the activity of a specific protein in the body that causes cancer cells to live and grow. By preventing this protein from working, Calquence (Acalabrutinib) may help decrease the number of cancer cells and slow the spread of the disease.

Calquence (Acalabrutinib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Calquence (Acalabrutinib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Calquence (Acalabrutinib) may not be used for all of the conditions discussed here.

Your doctor may have suggested Calquence (Acalabrutinib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Calquence (Acalabrutinib), speak to your doctor. Do not stop taking Calquence (Acalabrutinib) without consulting your doctor.

Do not give Calquence (Acalabrutinib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Calquence (Acalabrutinib) if their doctor has not prescribed it.

Discreet Packaging

Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

The recommended dose of Calquence (Acalabrutinib) is 100 mg (1 capsule) taken by mouth, twice daily. The doses should be taken 12 hours apart and at the same time each day.

Calquence (Acalabrutinib) may be taken with or without food. Do not crush, chew, or open the capsule. It should be swallowed whole with some fluid.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Calquence (Acalabrutinib) exactly as prescribed by your doctor. If you miss a dose, and it is within 3 hours of the missed dose, take it as soon as possible and continue with your regular schedule. If it is more than 3 hours since the missed dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Calquence (Acalabrutinib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Calquence (Acalabrutinib). If you are concerned about side effects, discuss the risks and benefits of Calquence (Acalabrutinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Calquence (Acalabrutinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• arm, leg, back pain
• Constipation
• decreased appetite
• Diarrhea
• dizziness
• headache
• mouth sores
• nausea
• skin rash or redness
• stomach pain or cramps
• tingling, pain, or numbness in the hands, legs, or feet
• tiredness
• trouble sleeping
• unsteadiness, causing falls
• vomiting
• watery eyes

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• memory loss
• new cancers (skin or other)
• rapid, pounding heartbeat
• signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of infection (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• symptoms of irregular heartbeat (e.g., chest pain, dizziness, confusion, rapid, pounding heartbeat, shortness of breath)
• symptoms of Low Blood Pressure (e.g., fainting, dizziness, lightheadedness, blurred vision, nausea)
• symptoms of pneumonia (e.g., cough with or without mucus, fever, chills, difficult and painful breathing, shortness of breath when climbing stairs)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Calquence (Acalabrutinib).

Automatic Refills

We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

Each size 1 hard gelatin capsule, with a yellow body and blue cap, marked in black ink "ACA 100 mg", contains 100 mg of Calquence (Acalabrutinib). Nonmedicinal ingredients: ammonium hydroxide, black iron oxide, colloidal silicon dioxide, FD&C Blue 2 (Indigotine/Indigo carmine), gelatin, magnesium stearate, microcrystalline cellulose, partially pregelantinized starch (maize), propylene glycol, shellac, sodium starch glycolate (Type A), titanium dioxide, and yellow iron oxide.