What side effects are possible with Manerix (Moclobemide)?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Manerix (Moclobemide). If you are concerned about side effects, discuss the risks and benefits of Manerix (Moclobemide) with your doctor.

The following side effects have been reported by at least 1% of people taking Manerix (Moclobemide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Constipation
• Diarrhea
• dizziness
• dryness of mouth
• headache
• nausea
• trouble sleeping

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• agitation
• blurred vision or other changes in vision
• fast, racing, or irregular heartbeat
• feeling confused, disoriented, or lost
• new or worsened emotional problems
• slow heartbeat
• slurred speech
• stiff neck, severe throbbing headache
• symptoms of low sodium levels in the blood (e.g., achy, stiff or uncoordinated muscles, confusion, tiredness, weakness)
• thoughts of self-harm or hurting others

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a hypertensive reaction (e.g., severe headache with confusion and blurred vision, nausea, vomiting, severe anxiety, difficulty breathing, severe chest pain, seizures)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of serotonin syndrome (too much serotonin in the body; e.g., fast or racing heartbeat, loss of coordination, agitation, decreased reflexes, rapid changes in blood pressure, Fever, heavy sweating, confusion)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Manerix (Moclobemide).

150 mg
Each pale yellow, single-scored, biconvex, film-coated tablet contains 150 mg of Manerix (Moclobemide). Nonmedicinal ingredients: cornstarch, ethylcellulose, iron oxide, lactose, magnesium stearate, methylhydroxypropyl cellulose, polyethylene glycol, povidone, sodium starch glycolate, talc, and titanium dioxide.

300 mg
Each white, single-scored, biconvex, film-coated tablet contains 300 mg of Manerix (Moclobemide). Nonmedicinal ingredients: cornstarch, ethylcellulose, lactose, magnesium stearate, methylhydroxypropyl cellulose, polyethylene glycol, povidone, sodium starch glycolate, talc, and titanium dioxide.

Do not take Manerix (Moclobemide) if you:

• are allergic to Manerix (Moclobemide) or any ingredients of the medication
• are in an acute state of confusion
• are taking any of the following medications:
• Bupropion
• Dextromethorphan
• Meperidine
• other MAO inhibitors e.g., Tranylcypromine)
• Selegiline
• SNRI antidepressants e.g., Desvenlafaxine)
• SSRI antidepressants e.g., Fluoxetine, Sertraline)
• thioridazine
• Tramadol
• tricyclic antidepressants (e.g., Amitriptyline)
• "triptan" migraine medications (e.g., Sumatriptan)

There may be an interaction between Manerix (Moclobemide) and any of the following:

• alcohol
• acetylcholinesterase inhibitors (e.g., Donepezil, Galantamine, Rivastigmine)
• aclidinium
• alpha/beta agonists (e.g., Epinephrine, norepinephrine)
• alpha agonists (e.g., Clonidine, methyldopa)
• amphetamines (e.g., Dextroamphetamine)
• anesthetics (e.g., halothane)
• anti-emetic medications (e.g., Granisetron, Ondansetron)
• antihistamines (e.g,. cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotic medications (e.g., Haloperidol, Quetiapine, Risperidone)
• appetite suppressants (e.g., sibutramine, mazindol)
• Atomoxetine
• atropine
• azelastine
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• belladonna
• Benztropine
• beta-2 agonists (e.g., salbutamol, formoterol, terbutaline)
• Betahistine
• Bezafibrate
• botulinum toxin
• Bromocriptine
• bupropion
• Buspirone
• Cabergoline
• Carbamazepine
• Cimetidine
• clidinium
• Clobazam
• Clopidogrel
• Cyclobenzaprine
• decongestants (e.g., phenylephrine, oxymetazoline, Pseudoephedrine, tetrahydrazoline, xylometazoline)
• Dabrafenib
• delavirdine
• dextromethorphan
• Diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Nateglinide, Rosiglitazone)
• Diazepam
• Disopyramide
• Domperidone
• efavirenz
• Entacapone
• Enzalutamide
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• Esomeprazole
• Fesoterodine
• Flavoxate
• Gemfibrozil
• glaucoma medications (e.g., apraclonidine, brimonidine)
• isoniazid
• Glucagon
• glycopyrrolate
• ipratropium
• isoniazid
• ketotifen
• levodopa
• lithium
• Linezolid
• lopinavir
• Maprotiline
• meperidine
• methylene blue
• Methylphenidate
• Metoclopramide
• Midodrine
• Mirabegron
• Mirtazapine
• Modafinil
• other monoamine oxidase inhibitors (M.O.S. e.g., Manerix (Moclobemide), phenelzine, Rasagiline, selegiline, tranylcypromine)
• narcotic medications (e.g., Fentanyl, Morphine, Codeine, Oxycodone)
• nefazodone
• Octreotide
• Omeprazole
• orphenadrine
• Oxybutynin
• Phenobarbital
• Phenytoin
• Pizotifen
• potassium chloride
• quinidine
• quinine
• reserpine
• rifampin
• St. John's wort
• scopolamine
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, fluoxetine, Paroxetine, sertraline)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, Duloxetine, Venlafaxine)
• Solifenacin
• Stiripentol
• sympathomimetic medications (e.g., epinephrine, norepinephrine)
• Tapentadol
• Tetrabenazine
• tetrahydrozoline
• thioridazine
• tiotropium
• Ticlopidine
• Tizanidine
• Tolterodine
• tramadol
• Trazodone
• tricyclic antidepressants (e.g., amitriptyline, Clomipramine, Desipramine)
• "triptan" migraine medications (e.g., Rizatriptan, sumatriptan)
• Trospium
• Tryptophan
• umeclidinium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Manerix (Moclobemide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Manerix (Moclobemide).

Diet restrictions: Treatment with Manerix (Moclobemide) does not require special diet restrictions as with other MAO inhibitors such as Phenelzine. However, you should avoid consuming large amounts of certain foods, such as over 70 g of Marmite or 200 g of strong C.E.S.. As a safety measure, immediately report the sudden occurrence of any of the following:

• extremely fast or slow heart rate
• headache
• neck stiffness
• other unusual symptoms not previously experienced
• palpitations

Drowsiness/reduced alertness: Manerix (Moclobemide) may cause drowsiness or dizziness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how Manerix (Moclobemide) affects you.

Glaucoma: Manerix (Moclobemide) may cause symptoms of glaucoma (increased pressure in the eyes), such as blurred vision or eye pain or pressure, to become worse. If you have glaucoma, discuss with your doctor how Manerix (Moclobemide) may affect your medical condition, and whether any special monitoring is needed.

Kidney Disease: If you have reduced kidney function or kidney disease, discuss with your doctor how Manerix (Moclobemide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Manerix (Moclobemide), and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause Manerix (Moclobemide) to build up in the body, causing side effects. If you have reduced liver function or liver disease, discuss with your doctor how Manerix (Moclobemide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Manerix (Moclobemide), and whether any special monitoring is needed. For people with severe liver dysfunction, the daily dose of Manerix (Moclobemide) should be reduced to one-third or one-half of the standard dose.

Other medications: Treatment with tricyclic antidepressants may be started after Manerix (Moclobemide) has been stopped for at least 2 days. Do not start treatment with Manerix (Moclobemide) until antidepressants have been stopped for 2 weeks in most cases (wait 5 weeks after taking fluoxetine).

Suicidal or agitated behaviour: People taking Manerix (Moclobemide) may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after starting Manerix (Moclobemide). If you experience these side effects or notice them in a family member who is taking Manerix (Moclobemide), contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking Manerix (Moclobemide).

Thyroid disease: With certain types of thyroid disease, Manerix (Moclobemide) can cause a severe increase in blood pressure. If you have thyroid disease, discuss with your doctor how Manerix (Moclobemide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Manerix (Moclobemide), and whether any special monitoring is needed.

Pregnancy: The safety of using Manerix (Moclobemide) during pregnancy has not been established. Manerix (Moclobemide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Manerix (Moclobemide), contact your doctor immediately.

Breast-feeding: Manerix (Moclobemide) passes into breast milk. If you are a breast-feeding mother and are taking Manerix (Moclobemide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Manerix (Moclobemide) have not been established for children.