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Lenvima

Lenvima

Lenvatinib

Lenvima (Lenvatinib) belongs to the group of cancer-fighting medications called antineoplastics, and specifically to the family of medications called protein kinase inhibitors. It is used to treat Thyroid cancer that has recurred or metastasized (spread) or progressed despite radioactive-iodine treatment.

Available form

Capsule

Dosage

4mg/dose, 8mg/dose, 10mg/dose, 12mg/dose, 14mg/dose, 18mg/dose, 20mg/dose, 24mg/dose

Manufacturers

Eisai

Generic brand of

Lenvatinib

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Lenvima information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended adult dose of Lenvima (Lenvatinib) depends on the type of cancer being treated. Make sure you are clear on the correct number of capsules to take each day. Your doctor may adjust the dose based on side effects that you experience, until a balance between side effects and effectiveness is reached.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Lenvima (Lenvatinib) may be taken with food or on an empty stomach. Swallow the capsules whole, with water. Avoid contact with the powder inside the capsules. Do not open the capsules. Do not crush or chew the medication. If you have difficulty swallowing the capsules whole, you may dissolve the capsules (do not open them) in a small cup containing 1 tablespoon of water or apple juice. Let them sit for about 10 minutes, then stir the mixture for another 3 minutes. Swallow the mixture. Then rinse the cup with a small amount of water or apple juice and swallow the liquid to make sure you receive the full dose. It is important to take Lenvima (Lenvatinib) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is more than 12 hours since the missed dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Lenvima (Lenvatinib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Lenvima (Lenvatinib). If you are concerned about side effects, discuss the risks and benefits of Lenvima (Lenvatinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Lenvima (Lenvatinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain
cough
decreased appetite
Diarrhea
headache
hoarseness
mouth sores
nausea
tiredness
vomiting
weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

high blood pressure
rash, redness, or itching of the palms of the hands or soles of the feet
signs of Blood Clots (e.g., coughing up blood; pains in chest, groin, or leg – especially in calf of leg)
signs of bleeding problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of low calcium levels (e.g., muscle aches; cramps or stiffness; tingling in the lips, fingers, or feet; fast heartrate)
signs of heart failure (e.g., shortness of breath; fatigue; swelling in legs, ankles, or feet)
signs of heart rhythm irregularity (e.g., dizziness, palpitations, fainting, feeling of rapid, pounding heartbeat)
signs of an infection (e.g., Fever, flu-like symptoms, fatigue, weakness)
signs of irregular heartbeat (e.g., fainting, seizures)
signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
wounds that do not heal

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of aortic dissection (e.g., sudden severe pain in the back, chest or abdomen)
signs of a tear in the stomach or intestinal wall or an abnormal connection between two body parts (e.g., severe abdominal pain, nausea, vomiting, chills, fever or a leakage of air from the lungs causing sudden chest pain of difficulty breathing)
signs of Stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
signs of a Heart Attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
signs of posterior reversible encephalopathy syndrome (e.g., headache, seizures, weakness, confusion, high blood pressure, vision changes, difficulty thinking clearly)
very high blood pressure (e.g., headache, vision changes, nausea and vomiting)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Lenvima (Lenvatinib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Lenvima (Lenvatinib).

Abnormal heart rhythms: Lenvima (Lenvatinib) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation and should not be used in combination with Lenvima (Lenvatinib). You are more at risk for this type of abnormal heart rhythm and its complications if you:

are female
are older than 65 years of age
have a family history of sudden death due to heart attack or similar heart problems
have a history of heart disease or abnormal heart rhythms
have a slow heart rate
have congenital prolongation of the QT interval
have Diabetes
have had a stroke
have low potassium, magnesium, or calcium levels
have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Lenvima (Lenvatinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lenvima (Lenvatinib), and whether any special monitoring is needed.

Birth control: Effective birth control should be practiced while using Lenvima (Lenvatinib). Males taking Lenvima (Lenvatinib) should use a spermicide in addition to a barrier method of birth control (e.g., condoms). Women taking Lenvima (Lenvatinib) must also use reliable birth control while taking Lenvima (Lenvatinib) and for at least 1 month after stopping the medication. The effectiveness of hormonal contraceptives, such as birth control pills has not been determined. Barrier methods of birth control are recommended.

Bleeding: Lenvima (Lenvatinib) may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.

Blood clots: Lenvima (Lenvatinib) may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities.

If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack or stroke. Discuss with your doctor how Lenvima (Lenvatinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lenvima (Lenvatinib), and whether any special monitoring is needed. The safety of using Lenvima (Lenvatinib) within 6 months of experiencing a blood clot has not been studied.

Gastrointestinal problems and fistula formation: Lenvima (Lenvatinib) can cause perforation of the stomach or intestines or fistula formation (an abnormal connection between two body parts), resulting in a collapsed lung. If you experience severe abdominal pain, fever, vomiting, or nausea, or sudden chest pain and/or difficulty breathing, contact your doctor immediately.

Heart function: Lenvima (Lenvatinib) may cause symptoms of heart failure. Contact your doctor as soon as possible if you develop symptoms of heart problems such as shortness of breath, chest pain, rapid heartbeat, or swollen ankles.

High blood pressure: Lenvima (Lenvatinib) can cause increased blood pressure. If you have high blood pressure, discuss with your doctor how Lenvima (Lenvatinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lenvima (Lenvatinib), and whether any special monitoring is needed.

Kidney function/failure: Lenvima (Lenvatinib) can cause decreased kidney function or kidney failure. If you experience puffy hands, face, or feet, high blood pressure, unusual muscle cramping, or darkened urine, Lenvima (Lenvatinib) may be affecting how well your kidneys are working. If you notice any of these symptoms, contact your doctor as soon as possible.

Liver function: Lenvima (Lenvatinib) is broken down by the liver. Liver disease or reduced liver function may cause Lenvima (Lenvatinib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Lenvima (Lenvatinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lenvima (Lenvatinib), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Lenvima (Lenvatinib).

Lenvima (Lenvatinib) has been reported to cause a decrease in liver function, which has in rare cases caused liver failure. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Reversible posterior leukoencephalopathy syndrome (RPLS): This is a rare disease of the brain that may occur when using medications like Lenvima (Lenvatinib). If you experience signs and symptoms of RPLS, such as headache, seizures, change in awareness or consciousness or vision changes, contact your doctor immediately.

Surgery: Lenvima (Lenvatinib) causes changes to the blood and may slow down the healing process for wounds. Make sure anyone involved in your medical care knows you are taking Lenvima (Lenvatinib).

Thyroid function: Lenvima (Lenvatinib) can affect the way the body uses thyroid hormones. If you take thyroid replacement medication, your doctor may need to adjust the dose while you are taking Lenvima (Lenvatinib).

Pregnancy: Lenvima (Lenvatinib) is likely to harm the developing baby if it is taken by the mother while she is pregnant. Lenvima (Lenvatinib) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Lenvima (Lenvatinib), contact your doctor immediately.

Breast-feeding: It is not known if Lenvima (Lenvatinib) passes into breast milk. If you are a breast-feeding mother and are taking Lenvima (Lenvatinib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Lenvima (Lenvatinib) have not been established for children.

Seniors: People over the age of 65 years may be more at risk of side effects from Lenvima (Lenvatinib).

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