Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes D Flavone Vitamin D Supp (Vitamin-d3). If you are concerned about side effects, discuss the risks and benefits of D Flavone Vitamin D Supp (Vitamin-d3) with your doctor.

The following side effects have been reported by at least 1% of people taking D Flavone Vitamin D Supp (Vitamin-d3). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Diarrhea
• headache
• nausea
• skin rash
• tingling feeling in hands, feet, and around lips
• tiredness
• vomiting
• weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• chest pain
• increased blood cholesterol levels
• signs of bleeding, e.g.:
• blood in stools
• blood in urine
• bloody nose
• coughing blood
• cuts that don't stop bleeding
• signs of infections, symptoms may include:
• Fever or chills
• headache
• listlessness
• prolonged dizziness
• severe diarrhea
• shortness of breath
• stiff neck
• weight loss
• signs of liver problems, e.g.:
• dark urine
• diarrhea
• loss of appetite
• nausea
• pale stools
• vomiting
• weight loss
• yellowing of the skin or whites of the eyes
• symptoms of high blood sugar such as frequent urination or increased thirst

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (swelling of face or throat, Hives, or difficulty breathing)
• signs of pancreatitis, e.g.:
• abdominal pain on the upper left side
• back pain
• chills
• fever
• nausea
• rapid heartbeat
• swollen abdomen
• signs of a severe skin reaction, e.g.:
• a rash combined with fever or discomfort
• a rash covering a large area of the body
• a rash that spreads quickly
• blistering
• peeling

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking D Flavone Vitamin D Supp (Vitamin-d3).

Film-coated tablets

100 mg/25 mg
Each pale yellow, film-coated tablet, embossed with the Abbott logo and the Abbo-Code "KC", contains 100 mg of lopinavir and 25 mg of ritonavir. Nonmedicinal ingredients: copovidone, sorbitan monolaurate, colloidal silicon dioxide, and sodium stearyl fumarate; film-coating: polyvinyl alcohol, titanium dioxide, talc, Polyethylene Glycol 3350, and yellow ferric oxide E172.

200 mg/50 mg
Each yellow, film-coated tablet, embossed with the Abbott logo and the Abbo-Code "KA", contains 200 mg of lopinavir and 50 mg of ritonavir. Nonmedicinal ingredients: colloidal silicon dioxide, copovidone, sodium stearyl fumarate, and sorbitan monolaurate; film-coating: colloidal silicon dioxide, hydroxypropyl cellulose, hypromellose, polyethylene glycol 400, polyethylene glycol 3350, polysorbate 80, talc, yellow ferric oxide E172, and titanium dioxide.

Oral solution

Each mL of light yellow-to-orange liquid contains 80 mg of lopinavir and 20 mg of ritonavir. Nonmedicinal ingredients: acesulfame potassium, alcohol, artificial cotton candy flavour, citric acid, glycerin, high fructose corn syrup, Magnasweet-110 flavour, menthol, natural and artificial vanilla flavour, peppermint oil, polyoxyl 40 hydrogenated castor oil, povidone, propylene glycol, saccharin sodium, sodium chloride, sodium citrate, and water.

Do not take D Flavone Vitamin D Supp (Vitamin-d3) if you:

• are allergic to lopinavir, ritonavir, or any ingredients of the medication
• are taking any of the following medications:
• Alfuzosin
• Apalutamide
• cisapride
• Colchicine
• Dihydroergotamine
• Dronedarone
• elbasvir - grazoprevir
• ergonovine
• ergotamine
• Lomitapide
• Lovastatin
• Lurasidone
• methylergonovine
• midazolam
• Pimozide
• rifampin
• salmeterol
• Sildenafil
• Simvastatin
• St. John's wort
• Triazolam
• Vardenafil
• Venetoclax

Do not take the liquid form of D Flavone Vitamin D Supp (Vitamin-d3) if you:

• are pregnant
• have decreased liver function or liver disease
• have decreased kidney function or Kidney Disease
• are taking disulfiram or Metronidazole

There may be an interaction between lopinavir - ritonavir and any of the following:

• Aliskiren
• alpha-blockers (e.g., alfuzosin, Doxazosin, Silodosin, Tamsulosin)
• amantadine
• antiarrhythmic medications (e.g., Amiodarone, Flecainide, lidocaine, procainamide, Propafenone, quinidine, sotalol)
• anticancer medications (e.g., Cabazitaxel, Docetaxel, Doxorubicin, Etoposide, Ifosfamide, Irinotecan, Vincristine)
• anticonvulsants (e.g., Carbamazepine, Lamotrigine, Phenobarbital, Phenytoin)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• apalutamide
• Apixaban
• Aprepitant
• Atomoxetine
• atovaquone
• "azole" antifungal agents (e.g., itraconazole, ketoconazole, Voriconazole)
• benzodiazepines (e.g., Alprazolam, midazolam, triazolam)
• birth control pills
• Bosentan
• Brinzolamide
• Bromocriptine
• Buprenorphine
• Bupropion
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, verapamil)
• cannabis
• Carvedilol
• chloral hydrate
• chloroquine
• Clopidogrel
• Cobicistat
• colchicine
• conivaptan
• Cyclosporine
• dabigatran
• Darifenacin
• Deferasirox
• Dextromethorphan
• diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Repaglinide, Rosiglitazone)
• Digoxin
• disulfiram
• Domperidone
• e doxa ban
• Elagolix
• Enzalutamide
• Eplerenone
• ergot derivatives (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Everolimus
• Fingolimod
• Flibanserin
• formoterol
• Galantamine
• "gliptin" diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• grapefruit juice
• Guanfacine
• H2 antagonists (e.g., Famotidine, Ranitidine)
• Hepatitis C antivirals (e.g., daclatasvir, dasabuvir, ledipasvir, paritaprevir, ombitasvir, sofosbuvir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, nevirapine)
• HIV nucleoside reverse transcriptase inhibitors (NRTIs; e.g., abacavir, didanosine, tenofovir, zidovudine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Indacaterol
• inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
• intranasal corticosteroids (e.g., fluticasone)
• Ivabradine
• ivermectin
• Levomilnacipran
• lithium
• lomitapide
• Loperamide
• Macitentan
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Maprotiline
• maraviroc
• mefloquine
• Methadone
• methamphetamine
• metronidazole
• mifepristone
• Mirtazapine
• Modafinil
• Montelukast
• Nadolol
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nitrates (e.g., isosorbide dinitrate,  isosorbide mononitrate)
• Octreotide
• oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
• Orlistat
• Oxybutynin
• phosphodiesterase-5 inhibitors (e.g., sildenafil, Tadalafil, vardenafil)
• Prasugrel
• praziquantel
• Primaquine
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• Prucalopride
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• rifabutin
• rifampin
• rifaximin
• rilpivirine
• Riociguat
• Rivaroxaban
• Romidepsin
• St. John's wort
• salmeterol
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Paroxetine, Sertraline)
• Selegiline
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• siltuximab
• Sirolimus
• Solifenacin
• "statin" cholesterol reducing medications (e.g., Atorvastatin, lovastatin, simvastatin)
• suvorexant
• tacrolimus
• Tamoxifen
• Tetrabenazine
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• Thyroid replacements (e.g., dessicated thyroid, Levothyroxine)
• Ticagrelor
• Ticlopidine
• Tizanidine
• Tocilizumab
• Tolterodine
• Tolvaptan
• Tramadol
• Trazodone
• tretinoin
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• "triptan" migraine medications (e.g., Almotriptan, Eletriptan,)
• tyrosine kinase inhibitors (e.g., Bosutinib, Dasatinib, imatinib, Nilotinib)
• Ulipristal
• Venlafaxine
• vilanterol
• Warfarin
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with D Flavone Vitamin D Supp (Vitamin-d3). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take D Flavone Vitamin D Supp (Vitamin-d3).

Abnormal heart rhythms: D Flavone Vitamin D Supp (Vitamin-d3) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, pimozide, moxifloxacin, Mefloquine, pentamidine, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with lopinavir - ritonavir. You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have Diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how D Flavone Vitamin D Supp (Vitamin-d3) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3), and whether any special monitoring is needed.

Alcohol content: The liquid form of lopinavir - ritonavir contains alcohol. If you have decreased kidney or liver function, a history of Alcoholism, Epilepsy or a brain injury, or are pregnant or a child, D Flavone Vitamin D Supp (Vitamin-d3) may not be appropriate for you. Talk to your doctor if you have concerns.

Blood tests: Lopinavir - ritonavir can cause changes in your blood test results, such as red blood cell count, platelet count, cholesterol level, and sugar level. Your doctor will explain these to you and monitor your blood levels.

Diabetes: Antiretroviral medications such as lopinavir - ritonavir may cause diabetes or increase blood sugar levels. If you have diabetes, discuss with your doctor how D Flavone Vitamin D Supp (Vitamin-d3) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3), and whether any special monitoring is required.

If you experience symptoms of diabetes, such as frequent urination or increased thirst, contact your doctor.

Heart conditions: People with heart disease or people who are taking certain medications (e.g., verapamil, atazanavir) should discuss with their doctor how D Flavone Vitamin D Supp (Vitamin-d3) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3), and whether any special monitoring is needed.

Hemophilia: Lopinavir - ritonavir may put people with hemophilia at a higher risk of bleeding while taking D Flavone Vitamin D Supp (Vitamin-d3). If you have hemophilia, discuss with your doctor how D Flavone Vitamin D Supp (Vitamin-d3) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3), and whether any special monitoring is needed.

High Cholesterol: Lopinavir - ritonavir may increase cholesterol and triglyceride levels. If you have high cholesterol or are taking medication to control your cholesterol level, discuss with your doctor how D Flavone Vitamin D Supp (Vitamin-d3) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3), and whether any special monitoring is needed.

Immune reconstitution inflammatory syndrome: D Flavone Vitamin D Supp (Vitamin-d3) may cause immune reconstitution syndrome, where signs and symptoms of inflammation from previous infections appear. These symptoms occur soon after starting anti-HIV medication and can vary. They are thought to occur as a result of the immune system improving and being able to fight infections that have been present without symptoms (such as pneumonia, herpes, or Tuberculosis). Report any new symptoms to your doctor immediately.

Liver problems: Decreased liver function or liver disease can cause lopinavir - ritonavir to build up in the body and may cause side effects. D Flavone Vitamin D Supp (Vitamin-d3) may also cause liver problems. People with liver disease or decreased liver function should discuss with their doctor how D Flavone Vitamin D Supp (Vitamin-d3) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3), and whether any special monitoring is needed.

If you experience symptoms of liver problems (e.g., abdominal pain, persistent vomiting, feeling unwell, fever, itching, yellowing of the skin and eyes, dark urine), contact your doctor immediately.

Pancreatitis (inflammation of the pancreas): Lopinavir - ritonavir may cause or worsen pancreatitis. If you have a history of or are at risk for developing pancreatitis, you should be closely monitored by your doctor while taking D Flavone Vitamin D Supp (Vitamin-d3). If you develop signs of pancreatitis (e.g., upper left abdominal pain, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen), contact your doctor.

Stopping the medication: If you stop taking D Flavone Vitamin D Supp (Vitamin-d3), your HIV infection could get worse. Take the medication exactly as prescribed by your doctor, and do not stop taking the medication without checking with your doctor first.

Pregnancy: D Flavone Vitamin D Supp (Vitamin-d3) should not be used during pregnancy unless the potential benefits outweigh risks. If you become pregnant while taking D Flavone Vitamin D Supp (Vitamin-d3), contact your doctor immediately. The oral solution should not be used during pregnancy due to the alcohol and propylene glycol content.

Breast-feeding: It is not known if lopinavir - ritonavir passes into breast milk. Women who have HIV infection should not breast-feed because of the risk of passing HIV to a baby who does not have the infection.

Children: The safety and effectiveness of D Flavone Vitamin D Supp (Vitamin-d3) have not been established for children younger than 6 months. D Flavone Vitamin D Supp (Vitamin-d3) is not recommended for this age group.