Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Relpax (Eletriptan). If you are concerned about side effects, discuss the risks and benefits of Relpax (Eletriptan) with your doctor.

The following side effects have been reported by at least 1% of people taking Relpax (Eletriptan). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dizziness
• feeling weak
• increased sweating
• muscle or joint pain or weakness
• nausea
• sleepiness or drowsiness
• stomach pain or cramping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• change in headache frequency
• difficulty swallowing
• eye irritation, discharge, or pain
• fainting
• leg swelling
• sensations of burning, heat, numbness, tightness, tingling, or warmth
• skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chest pain (severe)
• heaviness, tightness, or pressure in the arms, chest, jaw, neck, or shoulder
• irregular heartbeat
• significantly elevated blood pressure
• signs of an allergic reaction (shortness of breath or difficulty breathing; Hives; swelling of the eyes, mouth, lips, or throat)
• stomach pain with bloody Diarrhea

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Relpax (Eletriptan).

20 mg
Each orange, round, film-coated tablet, printed "REP20" on one side and "PFIZER" on the reverse contains Relpax (Eletriptan) HBr 24.2 mg equivalent to Relpax (Eletriptan) (base) 20 mg. Nonmedicinal ingredients: croscarmellose sodium, FD&C Yellow No. 6 Aluminum Lake, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, titanium dioxide, and triacetin.

40 mg
Each orange, round, film-coated tablet, printed "REP40" on one side and "PFIZER" on the reverse contains Relpax (Eletriptan) HBr 48.5 mg equivalent to Relpax (Eletriptan) (base) 40 mg. Nonmedicinal ingredients: croscarmellose sodium, FD&C Yellow No. 6 Aluminum Lake, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, titanium dioxide, and triacetin.

Do not take Relpax (Eletriptan) if you:

• are allergic to Relpax (Eletriptan) or any ingredients of the medication
• have a history of Heart Attack or silent heart ischemia
• have Angina pectoris (chest pain) and Prinzmetal angina (coronary artery vasospasm)
• have cerebrovascular (e.g., Stroke or transient ischemic attacks [TIAs]) or peripheral vascular syndromes (e.g., ischemic bowel disease, Raynaud's syndrome)
• have certain types of migraine headaches (e.g., basilar, hemiplegic, or ophthalmoplegic)
• have heart disease or a history of heart disease (e.g., heart valve disease, ischemic heart disease, congenital heart disease, abnormal heart rhythms)
• have high blood pressure that is severe or uncontrolled
• have severe liver disease
• have taken any of the following drugs in the past 72 hours: clarithromycin, itraconazole, ketoconazole, nelfinavir, or ritonavir
• have taken ergotamine-containing or ergot-type medications (such as Dihydroergotamine or methysergide) or another 5-hydroxytryptamine receptor agonist (e.g., Almotriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan) in the past 24 hours

There may be an interaction between Relpax (Eletriptan) and any of the following:

• Amiodarone
• amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Aprepitant
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• Bicalutamide
• Bromocriptine
• Buspirone
• Cabergoline
• conivaptan
• Crizotinib
• Cyclobenzaprine
• Dextromethorphan
• Diltiazem
• Dronedarone
• ergotamine-containing or ergot-type medications (e.g., dihydroergotamine or methysergide)
• grapefruit juice
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Idelalisib
• imatinib
• Linezolid
• lithium
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• methylene blue
• Methylphenidate
• Metoclopramide
• mifepristone
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Rasagiline, Selegiline, Tranylcypromine)
• other 5-hydroxytryptamine receptor agonists (e.g., almotriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
• Palbociclib
• selective serotonin receptor agonists (SSRIs; e.g., fluoxetine, Fluvoxamine, paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, venlafaxine)
• St. John's wort
• Tapentadol
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• Tryptophan
• Verapamil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Relpax (Eletriptan). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Relpax (Eletriptan).

Blood pressure: Relpax (Eletriptan) may increase blood pressure. If you have uncontrolled high blood pressure, do not take Relpax (Eletriptan).

Drowsiness/reduced alertness: Relpax (Eletriptan) may cause dizziness or drowsiness affecting your ability to safely drive or operate machinery. Avoid these and other hazardous tasks until you have determined how Relpax (Eletriptan) affects you.

Headache type: Relpax (Eletriptan) should only be used where there is a clear diagnosis of migraine headache.

Heart and blood vessel problems: Relpax (Eletriptan) can cause serious heart and blood vessel problems, including heart attack, stroke, and extremely high blood pressure that requires emergency treatment. If you have heart disease or a history of heart disease, do not take Relpax (Eletriptan) (see "Who should not take Relpax (Eletriptan)?" above). Talk to your doctor if you have any concerns.

It is strongly recommended that you not use Relpax (Eletriptan) if you are at risk for, but have not been diagnosed with, heart disease, unless an examination shows that you do not have heart disease. People at risk for heart disease include those with high blood pressure, High Cholesterol, Diabetes, or a strong family history of heart disease; people who smoke or are obese; women in early or natural Menopause; and men over 40 years old. If you belong to one of these groups of people, your doctor may also recommend regular heart checkups while you are taking Relpax (Eletriptan).

Kidney Disease: If you have decreased kidney function, doses of more than 20 mg of Relpax (Eletriptan) daily should be avoided, as Relpax (Eletriptan) may cause severe increases in blood pressure.

Liver disease: Liver disease or reduced liver function may cause Relpax (Eletriptan) to build up in the body, causing side effects. If you have reduced liver function, discuss with your doctor how Relpax (Eletriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Relpax (Eletriptan), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Relpax (Eletriptan). If you have severely reduced liver function, do not use Relpax (Eletriptan).

Medication overuse headaches: As with other pain relief medications, overuse of Relpax (Eletriptan) may lead to medication overuse headaches, or "rebound headaches," where the headache returns as the medication wears off. Avoid taking more of Relpax (Eletriptan) than is recommended by your doctor. If you experience more frequent headaches, contact your doctor as soon as possible.

Seizures: There have been rare reports of seizures experienced by people taking Relpax (Eletriptan). Most of these people had a previous history of Epilepsy or medical conditions that increase the risk of seizures. If you have a history of epilepsy or any condition that increases your risk of seizure, discuss with your doctor how Relpax (Eletriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Relpax (Eletriptan), and whether any special monitoring is needed.

Serotonin syndrome: Relpax (Eletriptan) may cause a rare but potentially life-threatening condition called serotonin syndrome, especially when used with other medications that increase serotonin levels (e.g., Fluoxetine, Paroxetine, Venlafaxine). Get immediate medical attention if you experience symptoms such as:

• agitation
• confusion
• diarrhea
• hallucinations
• fast heart rate
• Fever
• increased body temperature
• lack of coordination
• overactive reflexes
• nausea
• vomiting

Pregnancy: Relpax (Eletriptan) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Relpax (Eletriptan), contact your doctor immediately.

Breast-feeding: Relpax (Eletriptan) passes into breast milk. If you are a breast-feeding mother and are taking Relpax (Eletriptan), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: The safety and effectiveness of using Relpax (Eletriptan) have not been established for children and adolescents less than 18 years of age. Its use by this age group is not recommended.

Seniors: People over 65 years of age who take Relpax (Eletriptan) experience a greater increase in blood pressure than younger people. Experience with Relpax (Eletriptan) in people over 65 years of age is limited and its use is not recommended for this age group.