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Cordarone (Amiodarone) belongs to the family of medications known as antiarrhythmics. It is used to treat certain types of abnormal heart rhythms (Arrhythmias).
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Cordarone (Amiodarone) belongs to the family of medications known as antiarrhythmics. It is used to treat certain types of abnormal heart rhythms (Arrhythmias). It works by changing how electrical impulses affect the heart muscle and by making the heart beat more regularly. The effects of Cordarone (Amiodarone) may be noted as early as 3 days after starting treatment, but it is usually 1 to 3 weeks before beneficial effects are seen.
Cordarone (Amiodarone) may be available under multiple brand names and/or in several different forms. Any specific brand name of Cordarone (Amiodarone) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Cordarone (Amiodarone) may not be used for all of the conditions discussed here.
Your doctor may have suggested Cordarone (Amiodarone) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Cordarone (Amiodarone), speak to your doctor. Do not stop taking Cordarone (Amiodarone) without consulting your doctor.
Do not give Cordarone (Amiodarone) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Cordarone (Amiodarone) if their doctor has not prescribed it.
The recommended adult starting dose of Cordarone (Amiodarone) is usually from 800 mg to 1,600 mg daily for the first 1 to 3 weeks in divided doses. The dose is eventually reduced to 200 mg to 400 mg once daily as prescribed by your doctor and according to circumstances. Cordarone (Amiodarone) may be taken with or without meals, but should be taken in the same manner each day. Do not take grapefruit juice during Cordarone (Amiodarone) treatment because blood levels of Cordarone (Amiodarone) may increase, causing an increase in side effects.
The injectable form of Cordarone (Amiodarone) may be used in hospitals under specific circumstances. The recommended dose varies according individual circumstances.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Cordarone (Amiodarone) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed or skipped dose. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Cordarone (Amiodarone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Cordarone (Amiodarone). If you are concerned about side effects, discuss the risks and benefits of Cordarone (Amiodarone) with your doctor.
The following side effects have been reported by at least 1% of people taking Cordarone (Amiodarone). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Cordarone (Amiodarone).
Cordarone is no longer being manufactured for sale in Canada. For brands that may still be available, search under Cordarone (Amiodarone). This article is being kept available for reference purposes only. If you are using Cordarone (Amiodarone), speak with your doctor or pharmacist for information about your treatment options.
Do not use Cordarone (Amiodarone) if you:
Do not give Cordarone (Amiodarone) to people in cardiogenic shock.
There may be an interaction between Cordarone (Amiodarone) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Cordarone (Amiodarone). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Cordarone (Amiodarone).
Abnormal heart rhythm: Cordarone (Amiodarone) may cause a heart rhythm disturbance called QT prolongation. It can also worsen or trigger an irregular heart beat (arrhythmia). Your doctor will monitor your heart rhythm regularly while you are taking Cordarone (Amiodarone) with a test called an electrocardiogram (ECG).
Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Dolasetron mesylate, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should only be used in combination with Cordarone (Amiodarone) if the benefit of receiving both medications outweighs the risk of side effects. You are more at risk for this type of abnormal heart rhythm and its complications if you:
Blood potassium and magnesium levels: People with low levels of potassium or magnesium should have these conditions corrected before starting Cordarone (Amiodarone), as the risk of worsening abnormal heart rhythms may be increased.
Congestive Heart Failure: Cordarone (Amiodarone) may cause congestive heart failure to worsen. If you have congestive heart failure, discuss with your doctor how Cordarone (Amiodarone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Cordarone (Amiodarone), and whether any special monitoring is needed.
General: Due to the potential for serious side effects, Cordarone (Amiodarone) should only be given by physicians who are experienced in the treatment of abnormal heart rhythms.
Liver disease: Cordarone (Amiodarone) may cause liver problems, so your doctor should monitor your liver function regularly. If you have liver disease, discuss with your doctor how Cordarone (Amiodarone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Cordarone (Amiodarone), and whether any special monitoring is needed. People with hepatitis should not take Cordarone (Amiodarone).
Lung problems: Cordarone (Amiodarone) can cause lung problems (Pulmonary Fibrosis, permanent scarring of the lungs) that, in some cases, can be fatal. If you experience any difficulty breathing, wheezing, fever, shortness of breath, cough, or coughing up of blood, accompanied by weakness and weight loss while taking Cordarone (Amiodarone), tell your doctor immediately.
Skin: Cordarone (Amiodarone) may make your skin more sensitive to the sun. Use sunscreen with minimum SPF15 and protective clothing while taking Cordarone (Amiodarone). Some people using Cordarone (Amiodarone) for long-term treatment may develop a blue-grey discoloration of exposed skin. Report any changes in skin colour to your doctor.
Surgery: If you are scheduled for surgery, inform all doctors involved in your care that you are taking Cordarone (Amiodarone).
Thyroid disease: Cordarone (Amiodarone) can cause thyroid problems (both overactive and underactive). Your doctor will perform tests regularly to monitor your thyroid function prior to and during Cordarone (Amiodarone) treatment, especially if you are a senior or if you have a history of thyroid problems.
Vision problems: Cordarone (Amiodarone) may cause vision problems that may be severe or permanent. Regular eye exams are recommended during Cordarone (Amiodarone) treatment. If you notice any vision changes or problems, contact your doctor as soon as possible.
Pregnancy: Cordarone (Amiodarone) may harm a developing baby if it is taken by the mother during pregnancy. In particular, it has been noted to cause thyroid problems for the baby. Cordarone (Amiodarone) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Cordarone (Amiodarone), contact your doctor immediately.
Breast-feeding: Cordarone (Amiodarone) passes into breast milk. If you are a breast-feeding mother and are taking Cordarone (Amiodarone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of Cordarone (Amiodarone) for use by children have not been established.
Seniors: People over the age of 65 may require lower doses of Cordarone (Amiodarone).
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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