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Available Form:   Tablet
Manufacturer name:   Pro Doc Limitée
Generic name:   methotrimeprazine
Strength:   2mg, 5mg, 25mg, 50mg

What is Methotrimeprazine?

Methotrimeprazine belongs to the class of medications called phenothiazines. It is used to treat mental and emotional disorders, including Schizophrenia, manic-depressive syndromes and other psychotic disorders.

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Methotrimeprazine frequently asked questions

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Methotrimeprazine in Canada?

Shipping cost for Methotrimeprazine to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Methotrimeprazine delivered to my home?

You could get Methotrimeprazine delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Methotrimeprazine in Canada for free?

You can get Methotrimeprazine for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Methotrimeprazine for free.

Methotrimeprazine How to Take

Methotrimeprazine belongs to the class of medications called phenothiazines. It is used to treat mental and emotional disorders, including Schizophrenia, manic-depressive syndromes and other psychotic disorders. It can also be used in conditions associated with anxiety and tension, as a pain reliever (for certain types of pain), as a sedative, and for nausea and vomiting caused by certain conditions.

Methotrimeprazine may be available under multiple brand names and/or in several different forms. Any specific brand name of Methotrimeprazine may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Methotrimeprazine may not be used for all of the conditions discussed here.

Your doctor may have suggested Methotrimeprazine for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Methotrimeprazine, speak to your doctor. Do not stop taking Methotrimeprazine without consulting your doctor.

Do not give Methotrimeprazine to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Methotrimeprazine if their doctor has not prescribed it.

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Methotrimeprazine Dosage

The dose of Methotrimeprazine varies widely depending on the condition being treated and the circumstances and age of the person being treated.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Methotrimeprazine exactly as prescribed by your doctor. If you miss a dose, contact your doctor or pharmacist for advice. Do not take a double dose to make up for a missed one.

Store Methotrimeprazine at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Methotrimeprazine Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Methotrimeprazine. If you are concerned about side effects, discuss the risks and benefits of Methotrimeprazine with your doctor.

The following side effects have been reported by at least 1% of people taking Methotrimeprazine. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • decreased sweating
  • drowsiness (appears early in treatment and gradually disappears during the first weeks or with an adjustment in the dosage)
  • dryness of the mouth
  • flu-like symptoms
  • increased skin sensitivity to sunlight
  • weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • difficulty urinating
  • fast or irregular heartbeat, high or low blood pressure
  • high blood sugar (symptoms include increased thirst, decreased appetite, nausea and vomiting)
  • low blood pressure (symptoms include dizziness, especially when moving to a standing position)
  • new or worsening Constipation
  • signs of infection (symptoms may include Fever or chills, severe Diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • allergic reactions, such as skin rash, redness, or itching
  • increased sweating, confusion, or reduced consciousness
  • muscle twitching or uncontrolled movements of the mouth, tongue, face, or jaw
  • painful erection lasting more than 4 hours
  • respiratory infection, fever, flu-like symptoms, coughing, difficult or fast breathing
  • shaking, muscle stiffness, body spasm, impairment of voluntary movement, upward eye rolling, exaggeration of reflexes or drooling
  • seizures
  • symptoms of a blood clot (e.g., sharp pain in the foot or unexplained leg swelling, pain, redness, or tenderness, sharp pain in the chest, coughing blood, or sudden shortness of breath)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Methotrimeprazine.

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Methotrimeprazine Available Form

July 27, 2011 

Methotrimeprazine by Pro Doc Limitee is no longer being manufactured for sale in Canada. For brands that may still be available, search under methotrimeprazine. This article is being kept available for reference purposes only. If you are using Methotrimeprazine, speak with your doctor or pharmacist for information about your treatment options.

Methotrimeprazine Contraindications

Do not take methotrimeprazine if you:

  • are allergic to methotrimeprazine, or any ingredient of Methotrimeprazine
  • are allergic to other phenothiazines (e.g., Chlorpromazine)
  • are excessively sedated by alcohol, sleeping pills, tranquilizers, pain relievers, or narcotics
  • have a blood disorder
  • have liver problems
  • have brain damage
  • have pheochromocytoma (a tumour in the adrenal glands)
  • are being treated with regional or spinal pain relief (epidural infusion)
  • are experiencing severely Low Blood Pressure or severe heart disorder

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Methotrimeprazine Precautions

There may be an interaction between methotrimeprazine and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Methotrimeprazine. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Methotrimeprazine Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Methotrimeprazine.

Abnormal heart rhythms: Methotrimeprazine can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, chlorpromazine, droperidol, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with methotrimeprazine. You are more at risk for this type of abnormal heart rhythm and its complications if you:

  • are female
  • are older than 65 years of age
  • have a family history of sudden cardiac death
  • have a history of heart disease or abnormal heart rhythms
  • have a slow heart rate
  • have congenital prolongation of the QT interval
  • have Diabetes
  • have had a Stroke
  • have low potassium, magnesium, or calcium levels
  • have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Methotrimeprazine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Methotrimeprazine, and whether any special monitoring is needed.

Blood Clots: Rarely, Methotrimeprazine may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities. If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as Heart Attack, stroke, or clots in the deep veins of your leg. Discuss with your doctor how Methotrimeprazine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Methotrimeprazine, and whether any special monitoring is needed.

If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision, or difficulty speaking, contact your doctor immediately.

Body temperature: Methotrimeprazine, like other antipsychotic medications, may interfere with your body's ability to regulate body temperature. People who exercise vigorously, who are exposed to extreme heat, are dehydrated, or are taking anticholinergic medications (e.g., Benztropine, Oxybutynin) are more at risk. Contact your doctor as soon as possible if you feel very hot and are unable to cool.

Take care to avoid overheating during strenuous exercise or in hot temperatures, and avoid becoming dehydrated by drinking enough fluids.

Diabetes: Methotrimeprazine may increase blood sugar for people with diabetes or those who are at risk for diabetes. If you have diabetes, monitor your blood sugar frequently as recommended by your doctor. If you experience symptoms of high blood sugar (e.g., increased urination, increased thirst, increased eating, and weakness) while taking Methotrimeprazine, contact your doctor.

Dizziness/lightheadedness: In high doses, dizziness or lightheadedness when getting up from a sitting or lying position may be experienced at the start of treatment. To reduce the possibility of experiencing this, rise slowly from a sitting or lying position.

Drowsiness/reduced alertness: Methotrimeprazine can cause drowsiness and reduced alertness, especially during the first few days of treatment. Avoid driving, operating machinery, or performing other tasks that require mental alertness until you have determined how Methotrimeprazine affects you.

Glaucoma: Methotrimeprazine may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Methotrimeprazine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Methotrimeprazine, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Methotrimeprazine.

Neuroleptic malignant syndrome (NMS): Methotrimeprazine may cause a potentially fatal reaction called neuroleptic malignant syndrome (NMS). If you develop symptoms of NMS, such as muscle stiffness, fever, confusion, sweating, or irregular heartbeat, stop taking Methotrimeprazine and seek immediate medical attention.

Tardive dyskinesia: People taking Methotrimeprazine may develop tardive dyskinesia, a syndrome of uncontrolled body movements. This syndrome may be irreversible. If you develop uncontrolled or unusual body movements, contact your doctor as soon as possible.

Urinary tract problems: Methotrimeprazine can cause the symptoms of some urinary tract problems to become worse. If you have an enlarged prostate or another condition that causes urination to be difficult, discuss with your doctor how Methotrimeprazine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Methotrimeprazine, and whether any special monitoring is needed.

Pregnancy: Methotrimeprazine should not be used during pregnancy unless the benefits outweigh the risks. Infants born to mothers who used methotrimeprazine in the later part of pregnancy have had abnormal muscle movement and withdrawal symptoms, including decreased muscle tone, sleepiness, difficulty feeding and severe difficulty breathing after birth. These symptoms can be severe and need medical attention. If you become pregnant while taking Methotrimeprazine, contact your doctor immediately.

Breast-feeding: Methotrimeprazine passes into breast milk. If you are a breast-feeding mother and are taking Methotrimeprazine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Seniors: Seniors with Dementia who take Methotrimeprazine may be at an increased risk of death due either heart disease or infections compared to seniors who are not taking Methotrimeprazine. The use of methotrimeprazine by older adults is not recommended.

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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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